Academic Profile : Faculty

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Assoc Prof Mu Yuguang
Associate Professor, School of Biological Sciences
 
External Links
 
2006.4 - now Assistant Professor in School of Biological Sciences, NTU
2003.10 – 2006.3 Lee Kuan Yew Fellowship in School of Biological Sciences, NTU
2000.1 - 2003.9 Research Fellow (Wissenschaftlicher Mitarbeiter) in Institute of Theoretical Chemistry
Frankfurt am Main, Germany Biomolecular simulations and dynamics analyse,
cooperated with Prof. G. Stock and Prof. Peter Hamm
1999.1 - 2000.1 Alexander von Humboldt Fellow in Fraunhofer Institute of Integrated Systems and Device
Technology (IISB) Schottkystrasse 10, 91058 Erlangen, Germany cooperated with Prof.
Heiner Ryssel and Dr. Alex Burenkov. Simulation of atoms -solids interaction.

1997.7 - 1999.1 Lecturer , Department of photoelectronics, Shandong Univ.
Research Fields
1. MD simulation method and data analysis method development.
2. DNA dynamics, DNA ?protein, DNA-counterions interaction study.
3. Peptide, protein folding, unfolding study, specially aimed at folding, misfolding mechanism which could lead to amyloid fibril.
4. RNA dynamics and folding study.
 
  • Understanding the Role of Transglycosylase in Bacterial Cell Wall Synthesis
  • Mechanistic understanding and application of coronavirus fusion intermediate
  • Targeted protein design via constrained denoising diffusion probabilistic models
  • AI-facilitated development of pan-coronavirus fusion inhibitors
  • Age-related mRNA degradation by endoplasmic reticulum stress sensor IRE1
  • Improve protein-drug binding prediction using deep graph neural network
  • Untangling cancer re-wiring: Pan-Cancer mapping of transcription factor driven dysregulatory hotspots using AlphaFold2 and integrative machine learning
  • Activation Mechanism of A Protein Water Channel by Cardiolipin: Implications for the Fabrication of Block Copolymer Nanosheets
  • Investigating Kindlin-3 as an Adaptor Protein that Modulates Interleukin 2 Receptor Localization and Signaling
US 2022/0332892 A1: β-Peptido-Sugar-Copolymer (2024)
Abstract: There is provided a β-peptido sugar-copolymer having the structure of formula (I) as defined herein, or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of the same. There is provided a process to make the β-peptido sugar-copolymer as defined herein. There are further provided medical applications of the β-peptido sugar-copolymer as defined herein. In a preferred embodiment, a block-like copolymer poly(amido-D-glucose)-block-poly-β-(L)-homolysine (PDGu-b-PBLK) synthesized via anionic ring-opening polymerization (ROP) demonstrates an antimicrobial efficacy, an enhanced selectivity towards different bacteria, biocompatibility vs. mammalian cells and spontaneous assembly.