Academic Profile : Faculty
Prof Loh Teck Peng
Distinguished University Professor, School of Chemistry, Chemical Engineering and Biotechnology
Professor, School of Chemistry, Chemical Engineering and Biotechnology
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Loh Teck Peng joined Nanyang Technological University as Professor since February 2005. He was the Head of Division of Chemistry & Biological Chemistry till June 2008 where he was promoted to the Associate Chair (Research). During his 11 years, from 1994 to 2005, at National University of Singapore, he had risen from the ranks of a Lecturer, Senior Lecturer, and Associate Professor to a Professor in 2004. He was also the Program leader of the Medicinal Chemistry program in NUS.
Besides being engaged in teaching, research and participation in international conferences, his professional appointments include the Advisory Board Member of upcoming ISCFC-07 held in NTU 2007, Advisory Board Member of Chemistry Communications coordinator of “Asia Core Program”, Honorary Secretary of Singapore National Institute of Chemistry, Chairman of the Singapore International Chemistry Conference (SICC-4), External Advisory Board Member of Singapore Polytechnic, External Examiner of Singapore Polytechnic (Diploma of Chemical Process Technology) since 2007, Co-Chairman of the ISCIC-6 & ISCOC-9 2006 and sits in the Technical Committee on National Drinking Water Quality Standards. He is also a member of the SCBE Promotion and Tenure Committee.
Besides being engaged in teaching, research and participation in international conferences, his professional appointments include the Advisory Board Member of upcoming ISCFC-07 held in NTU 2007, Advisory Board Member of Chemistry Communications coordinator of “Asia Core Program”, Honorary Secretary of Singapore National Institute of Chemistry, Chairman of the Singapore International Chemistry Conference (SICC-4), External Advisory Board Member of Singapore Polytechnic, External Examiner of Singapore Polytechnic (Diploma of Chemical Process Technology) since 2007, Co-Chairman of the ISCIC-6 & ISCOC-9 2006 and sits in the Technical Committee on National Drinking Water Quality Standards. He is also a member of the SCBE Promotion and Tenure Committee.
Teck Peng's research interests encompass a very wide array in organic synthesis. Research activities include green chemistry, asymmetric synthesis, the development of new synthetic methodology, and total synthesis of architecturally complex organic molecules with interesting biological activities. He also discovered many new concepts and methods for organic synthesis and completed the total synthesis of many complex molecules.
To date, he has published 153 papers in international refereed journals, 106 conference papers, 5 book chapters, Hirsch-index of 38 and a total number of 3891 citations.
He has been the Principal Investigator of several research grants, with total exceeding S$5 million, awarded by A*Star and Ministry of Education. Being the program leader of Medicinal Chemistry at National University of Singapore, he spearheaded a number of main programs and they were completed successfully.
He has been a frequent plenary speaker or invited speaker at many international conferences. Recently, he is invited to the Editorial Advisory Board of ChemComm to shape one of the world?s top chemistry journals. He has also been frequently invited to write book chapters, review articles, etc.
Teck Peng was awarded the prestigious Japanese Government (Mombusho) scholarship, which was only given to 5 students in Malaysia every year, from 1982 to 1989. In 1997, National University of Singapore bestowed him the University Outstanding Researcher Award. He has been the Adjunct Professor of Soo Chow University (China) and Tsukuba University (Japan) since 2002 and 2005 respectively. He was also the Visiting Professor of Columbia Medical School, Columbia University (USA) from 2002 to 2003. Recently, he was awarded by NTU for NTU Research Innovation Award.
To date, he has published 153 papers in international refereed journals, 106 conference papers, 5 book chapters, Hirsch-index of 38 and a total number of 3891 citations.
He has been the Principal Investigator of several research grants, with total exceeding S$5 million, awarded by A*Star and Ministry of Education. Being the program leader of Medicinal Chemistry at National University of Singapore, he spearheaded a number of main programs and they were completed successfully.
He has been a frequent plenary speaker or invited speaker at many international conferences. Recently, he is invited to the Editorial Advisory Board of ChemComm to shape one of the world?s top chemistry journals. He has also been frequently invited to write book chapters, review articles, etc.
Teck Peng was awarded the prestigious Japanese Government (Mombusho) scholarship, which was only given to 5 students in Malaysia every year, from 1982 to 1989. In 1997, National University of Singapore bestowed him the University Outstanding Researcher Award. He has been the Adjunct Professor of Soo Chow University (China) and Tsukuba University (Japan) since 2002 and 2005 respectively. He was also the Visiting Professor of Columbia Medical School, Columbia University (USA) from 2002 to 2003. Recently, he was awarded by NTU for NTU Research Innovation Award.
- Developing a Toolbox for Next-Gen Circular Plastic Materials
- Development of More Robust and Recyclable Thermoset Polymers
US 2017/0029373 A1: Allenamides As An Orthogonal Handle For Selective Modification Of Cysteine In Peptides And Proteins (2019)
Abstract: There is provided a compound of formula I, having the structure: wherein R1 to R5 have the meanings given in the description.
US 2016/0207932 A1: Novel Tricyclic Chiral Compounds and their use in Asymmetric Catalysis (2018)
Abstract: The present invention relates to a compound of general Formula (VIII), the compound having a bowl-shaped conformation, its formation and its use in asymmetric catalysis. In Formula (VIII), M is a metal selected from the group consisting of Group 1 to Group 14 metals, lanthanides and actinides; R is one of —COOR3, —R4COOR3, —R4CHO, —R4COR3, —R4CONR5R6, —R4COX, —R4OP(═O)(OH)2, —R4P(═O)(OH)2), —R4C(O)C(R3)CR5R6 and R4CO2C(R3)O, wherein R1, R2, R3, R4, R5 and R6 are as defined herein.
US 2016/0031817 A1: 3-Piperidone Compounds And Their Use As Neurokinin-1 (NK1) Receptor Antagonists (2016)
Abstract: The invention relates to 3-piperidone compounds, and in particular, to (2S)-phenyl-3-piperidone and its synthesis method. Use of the thus-synthesized 3-piperidone compounds as potent neurokinin-1 (NK1) receptor antagonists is also provided.
US 2015/0166499 A1: Small Molecule Catalyst For 5-Hydroxymethylfurfural Production From Saccharides (2016)
Abstract: The disclosure provides the use of aryl or heteroaryl boronic acid in the preparation of 5-(hydroxymethyl)fufural (HMF) from saccharides. The aryl or heteroaryl boronic bearing electron-withdrawing groups on the aryl or heteroaryl ring of the boronic acid provided good yields. The disclosure provides a method for preparing HMF from saccharides in the presence of aryl or heteroaryl boronic acid. The disclosure provides a method for converting a saccharide other than fructose in fructose via a dehydrogenation reaction catalyzed by aryl or heteroaryl boronic acid.
US 2011/0269972 A1: Tricyclic Chiral Compounds and their use in Asymmetric Catalysis (2015)
Abstract: The present invention relates to a compound of general Formula (XX), its formation and its use in asymmetric catalysis. In Formula (XX) R and R31 are independently —COOR3, —R4COOR3, —R4CHO, —R4COR3, —R4CONR5R6, —R4COX, —R4OP(═O)(OH)2, —R4P(═O)(OH)2), —R4C(O)C(R3)CR5R6 and —R4CO2COR3.
US 2013/0165682 A1: Method For The Synthesis Of An Amino Acetal (2015)
Abstract: The present invention relates to a method for the synthesis of an α amino acetal, comprising (i) oxidizing a tertiary amine in the presence of a copper catalyst, at least one oxidant and a solvent, or (ii) reacting a secondary amine and an aliphatic aldehyde in the presence of a copper catalyst, at least one oxidant and a solvent.
US 2012/0088916 A1: Octahydro Biquinoline Compound (2014)
Abstract: The present invention relates to an octahydro biquinoline compound. Provided is also a method of separating the octahydro biquinoline compound into enantiomers. The octahydro biquinoline compound is of the general formula (V): In formula (V) R1 is one of H, a protective group and an aliphatic group, with the aliphatic group having a main chain of a length of 1 to about 10 carbon atoms, comprising 0 to about 6 heteroatoms selected from the group consisting of N, O, S, Se and Si. R2 and R3 are independent from one another selected from the group consisting of (i) H, (ii) one of an aliphatic, an alicyclic, an aromatic, an arylaliphatic, and an arylalicyclic group comprising 0 to about 6 heteroatoms selected from the group consisting of N, O, S, Se and Si, an ester, a carbonate group, a carbamoyl group and a phosphate ester.
Abstract: There is provided a compound of formula I, having the structure: wherein R1 to R5 have the meanings given in the description.
US 2016/0207932 A1: Novel Tricyclic Chiral Compounds and their use in Asymmetric Catalysis (2018)
Abstract: The present invention relates to a compound of general Formula (VIII), the compound having a bowl-shaped conformation, its formation and its use in asymmetric catalysis. In Formula (VIII), M is a metal selected from the group consisting of Group 1 to Group 14 metals, lanthanides and actinides; R is one of —COOR3, —R4COOR3, —R4CHO, —R4COR3, —R4CONR5R6, —R4COX, —R4OP(═O)(OH)2, —R4P(═O)(OH)2), —R4C(O)C(R3)CR5R6 and R4CO2C(R3)O, wherein R1, R2, R3, R4, R5 and R6 are as defined herein.
US 2016/0031817 A1: 3-Piperidone Compounds And Their Use As Neurokinin-1 (NK1) Receptor Antagonists (2016)
Abstract: The invention relates to 3-piperidone compounds, and in particular, to (2S)-phenyl-3-piperidone and its synthesis method. Use of the thus-synthesized 3-piperidone compounds as potent neurokinin-1 (NK1) receptor antagonists is also provided.
US 2015/0166499 A1: Small Molecule Catalyst For 5-Hydroxymethylfurfural Production From Saccharides (2016)
Abstract: The disclosure provides the use of aryl or heteroaryl boronic acid in the preparation of 5-(hydroxymethyl)fufural (HMF) from saccharides. The aryl or heteroaryl boronic bearing electron-withdrawing groups on the aryl or heteroaryl ring of the boronic acid provided good yields. The disclosure provides a method for preparing HMF from saccharides in the presence of aryl or heteroaryl boronic acid. The disclosure provides a method for converting a saccharide other than fructose in fructose via a dehydrogenation reaction catalyzed by aryl or heteroaryl boronic acid.
US 2011/0269972 A1: Tricyclic Chiral Compounds and their use in Asymmetric Catalysis (2015)
Abstract: The present invention relates to a compound of general Formula (XX), its formation and its use in asymmetric catalysis. In Formula (XX) R and R31 are independently —COOR3, —R4COOR3, —R4CHO, —R4COR3, —R4CONR5R6, —R4COX, —R4OP(═O)(OH)2, —R4P(═O)(OH)2), —R4C(O)C(R3)CR5R6 and —R4CO2COR3.
US 2013/0165682 A1: Method For The Synthesis Of An Amino Acetal (2015)
Abstract: The present invention relates to a method for the synthesis of an α amino acetal, comprising (i) oxidizing a tertiary amine in the presence of a copper catalyst, at least one oxidant and a solvent, or (ii) reacting a secondary amine and an aliphatic aldehyde in the presence of a copper catalyst, at least one oxidant and a solvent.
US 2012/0088916 A1: Octahydro Biquinoline Compound (2014)
Abstract: The present invention relates to an octahydro biquinoline compound. Provided is also a method of separating the octahydro biquinoline compound into enantiomers. The octahydro biquinoline compound is of the general formula (V): In formula (V) R1 is one of H, a protective group and an aliphatic group, with the aliphatic group having a main chain of a length of 1 to about 10 carbon atoms, comprising 0 to about 6 heteroatoms selected from the group consisting of N, O, S, Se and Si. R2 and R3 are independent from one another selected from the group consisting of (i) H, (ii) one of an aliphatic, an alicyclic, an aromatic, an arylaliphatic, and an arylalicyclic group comprising 0 to about 6 heteroatoms selected from the group consisting of N, O, S, Se and Si, an ester, a carbonate group, a carbamoyl group and a phosphate ester.
Courses Taught
CBC723 - Graduate Organic Chemistry
CM4032 - Current Topics in Synthetic Organic Chemistry
CM4032 - Current Topics in Synthetic Organic Chemistry