Academic Profile

Dr. Joachim Loo is currently Associate Professor in the School of Materials Science and Engineering (MSE), Nanyang Technological University (NTU). He holds a joint appointment at the Singapore Centre on Environmental Life Sciences Engineering (SCELSE), the Lee Kong Chian School of Medicine (LKCMed) and is a Visiting Scientist at the Harvard School of Public Health (HSPH), USA. He is also an international member of the Association of Pacific Rim Universities (APRU) for Sustainable Waste Management, and a member of the Coordinated Research Project (CRP) under the International Atomic Energy Agency (IAEA), United Nations (UN).
His research interests lies in designing encapsulation systems for controlled and targeted delivery from agri-food, biomedical, environmental to pharmaceutical applications. He has published more than 200 journal papers (h-index: 56 – Web of Science), three book chapters and filed more than 20 patents to his name, of which three has been licensed. He was also awarded the Bill and Melinda Gates Foundation grant to develop delivery systems for nutraceuticals. More recently, he spun-off two companies; LiberaTx and Dietrics, to formulate an extended-release oral drug delivery system and to valorise cellulose for fat absorption as a food ingredient, respectively.
As an educator, he was awarded the Nanyang Education Award (School) in 2011 and 2016, and more recently the Nanyang Education Award (College) in 2020. Currently, he is also managing several administrative portfolios, such as Associate Chair (Students) in MSE, Deputy Director (Curriculum) of the Renaissance Engineering Program (RE), and is currently a co-convenor of the ISO/TC 229 Nanotechnology National Working Group (WG3), under the Singapore Chemical Industry Council.
Loo Say Chye Joachim.jpg picture
Assoc Prof Loo Say Chye Joachim
Associate Chair (Students), School of Materials Science & Engineering
Associate Professor, School of Materials Science & Engineering
Associate Professor, Singapore Centre for Environmental Life Sciences Engineering
Courtesy Appointment with LKC, Lee Kong Chian School of Medicine (LKCMedicine)
Deputy Director, Renaissance Engineering Programme

I. Formulations, Encapsulation and Delivery (FED) Systems for Pharmaceutical and Nutraceutical Applications.
II. Controlled-release for Aquaculture Fish Feeds
III. Antimicrobial and Probiotics Delivery Systems
IV. Valorizing Waste as Encapsulant Materials.

1. LiberaTx Pte. Ltd.
2. Dietrics Pte. Ltd.

Relevant Patents (total: 20):
1. Lipid-polymer hybrid nanoparticles for localized and sustained delivery of antimicrobials. Singapore provisional patent application number 10201800129P. 5 Jan 2018.
2. Casein-loaded microcapsules and method of preparing the same. Singapore provisional patent application number 10201706305X. Dec 2017.
3. Method of preparing hollow microparticles and hollow microparticles prepared thereof. PAT/223/14/14/SG PRVPCT/SG2015/050483. Dec 2015.
4. Electrochemical detection of E. coli. US Provisional Patent. 2014. TD/091/14. PAT/091/14/14/US PRV. US Provisional application number 62/040,792. Aug 2014. PCT/SG2015/050274. Aug 2015. Singapore Patent Application No: 11201700274X
5. Floating capsules encapsulating particles loaded with one or more drugs. US Provisional Application no. 61/683,955 filed on 16-Aug-2012. US PCT Application No: PCT/SG2013/000282. 8 July 2013. National Phase: Singapore (11201500227S: 12 Jan 2015) and USA. Granted: USA Patent No. 9,381,163. Singapore Patent Application No : 11201500227S
6. Methods of manufacturing core-shell microparticles, and microparticles formed thereof. PCT Application No: PCT/SG2013/000051 filed 6-Feb-2013. Singapore Application No. 11201404038P.
7. Method for encapsulating particles. PCT Application No: PCT/SG2011/000414. National phase: Europe (Appl. No.: 11 842 853.1), Singapore (Appl. No.: 201303178-6). Assigned Singapore Patent No. 190009. Granted: Patent No. 9,616,031
8. Targeted drug delivery to bone. NTU TD ref: TD/024/08 – US Provisional No. 61/184,548 filed 5 Jun 2009 (lapsed). PCT Application no. PCT/SG2010/000214 filed 7-Jun-2010. National phase: Singapore, China, Europe, India and USA (No. 13/375,713). Granted. China Patent Application No : 201080034589.7
  • Combinatorial Supplementation of Fish Feeds through Encapsulation for Enhanced Growth Rates in Aquaculture

  • Microencapsulation of Nutritional Compounds with Okara Food Waste

  • Modulation of jade perch microbiome using encapsulated, host-derived microbial compositions for improved health in higher stocking density ponds

  • Nanyang Education Award (College)

  • Rapid ‘Test-pen’ Design for Next-generation Nasogastric Tubes (NG2T)

  • Stabilizing Dopamine Levels In Parkinson's Disease Through An Extended-Releasing Oral Formulation: Bridging The Gaps Towards Clinical Trials
  • Q Yang, TP Keerthisinghe, TRJ Tan, XQ Cao, MI Setyawati, G DeLoid, KW Ng, SCJ Loo, P Demokritou, ML Fang. A high-throughput method to characterize the gut bacteria growth upon engineered nanomaterial treatment. Environmental Science: Nano 2020. Accepted

  • L Jiang, HW Lee, SCJ Loo. Therapeutic Lipid-coated Hybrid Nanoparticles against Bacterial Infections. RSC Advances 2020. 10, 8497 – 8517

  • 4. K Sampathkumar, S Riyajan, CK Tan, P Demokritou, N Chudapongse, SCJ Loo. Small intestine specific delivery of anti-diabetic extracts from Withania coagulans using polysaccharide-based enteric-coated nanoparticles. ACS Omega 2019. 4, 12049−12057

  • 5. W Poh, NAB Rahman, Y Ostrovski, J Sznitman, K Pethe, SCJ Loo. Active Pulmonary Targeting against Tuberculosis (TB) via Triple–Encapsulation of Q203, Bedaquiline and Superparamagnetic Iron Oxides (SPIOs) in Nanoparticle Aggregates. Drug Delivery 2019. 26, 1039-1048

  • 6. YL Fan, XF Zheng, Y Ali, PO Berggren, SCJ Loo. Local release of rapamycin by microparticles delays islet rejection within the anterior chamber of the eye. Scientific Reports 2019. 2019. 9: 3918.

  • 7. YGJ Lim, KCW Poh, SCJ Loo. Hybrid Janus microparticles achieving selective encapsulation for theranostic applications via a facile solvent emulsion method. Macromolecular Rapid Communications. Accepted 2019.

  • L Jiang, SCJ Loo. Intelligent Nanoparticle-based Dressings for Bacterial Wound Infections. ACS Applied Biomaterials 2020.

  • KX Tan, V Chamundeswari, SCJ Loo. Prospects of Kefiran as a Food-derived Biopolymer for Agri-food and Biomedical Applications. RSC Advances 2020. 10, 25339

  • K Sampathkumar, KX Tan, SCJ Loo. Developing Nano-Delivery Systems for Agriculture and Food Applications with Nature-Derived Polymers. iScience 2020. 23 (5): 101055. 10.1016/j.isci.2020.101055

  • GJ Lim, J Low, SCJ Loo. Synthesis of Polymeric Janus Superstructures via a Facile Synthesis Method. Macromolecular Rapid Communications 2020. 41: 2000140