Academic Profile : Faculty

Loo Say Chye Joachim.jpg picture
Prof Loo Say Chye Joachim
Associate Dean (Students), College of Engineering
Professor, School of Materials Science & Engineering
Professor, Singapore Centre for Environmental Life Sciences Engineering
Professor, Lee Kong Chian School of Medicine (Courtesy Appointment)
Deputy Director, Renaissance Engineering Programme
External Links
Dr. Joachim Loo is currently Associate Professor in the School of Materials Science and Engineering (MSE), Nanyang Technological University (NTU). He holds a joint appointment at the Singapore Centre on Environmental Life Sciences Engineering (SCELSE), the Lee Kong Chian School of Medicine (LKCMed) and is a Visiting Scientist at the Harvard School of Public Health (HSPH), USA. He is also an international member of the Association of Pacific Rim Universities (APRU) for Sustainable Waste Management, and a member of the Coordinated Research Project (CRP) under the International Atomic Energy Agency (IAEA), United Nations (UN).
His research interests lies in designing encapsulation systems for controlled and targeted delivery from agri-food, biomedical, environmental to pharmaceutical applications. He has published more than 200 journal papers (h-index: 56 – Web of Science), three book chapters and filed more than 20 patents to his name, of which three has been licensed. He was also awarded the Bill and Melinda Gates Foundation grant to develop delivery systems for nutraceuticals. More recently, he spun-off two companies; LiberaTx and Dietrics, to formulate an extended-release oral drug delivery system and to valorise cellulose for fat absorption as a food ingredient, respectively.
As an educator, he was awarded the Nanyang Education Award (School) in 2011 and 2016, and more recently the Nanyang Education Award (College) in 2020. Currently, he is also managing several administrative portfolios, such as Associate Chair (Students) in MSE, and is currently a co-convenor of the ISO/TC 229 Nanotechnology National Working Group (WG3), under the Singapore Chemical Industry Council.
I. Formulations, Encapsulation and Delivery (FED) Systems for Pharmaceutical and Nutraceutical Applications.
II. Controlled-release for Aquaculture Fish Feeds
III. Antimicrobial and Probiotics Delivery Systems
IV. Valorizing Waste as Encapsulant Materials.

1. LiberaTx Pte. Ltd.
2. Dietrics Pte. Ltd.

Relevant Patents (total: 20):
1. Lipid-polymer hybrid nanoparticles for localized and sustained delivery of antimicrobials. Singapore provisional patent application number 10201800129P. 5 Jan 2018.
2. Casein-loaded microcapsules and method of preparing the same. Singapore provisional patent application number 10201706305X. Dec 2017.
3. Method of preparing hollow microparticles and hollow microparticles prepared thereof. PAT/223/14/14/SG PRVPCT/SG2015/050483. Dec 2015.
4. Electrochemical detection of E. coli. US Provisional Patent. 2014. TD/091/14. PAT/091/14/14/US PRV. US Provisional application number 62/040,792. Aug 2014. PCT/SG2015/050274. Aug 2015. Singapore Patent Application No: 11201700274X
5. Floating capsules encapsulating particles loaded with one or more drugs. US Provisional Application no. 61/683,955 filed on 16-Aug-2012. US PCT Application No: PCT/SG2013/000282. 8 July 2013. National Phase: Singapore (11201500227S: 12 Jan 2015) and USA. Granted: USA Patent No. 9,381,163. Singapore Patent Application No : 11201500227S
6. Methods of manufacturing core-shell microparticles, and microparticles formed thereof. PCT Application No: PCT/SG2013/000051 filed 6-Feb-2013. Singapore Application No. 11201404038P.
7. Method for encapsulating particles. PCT Application No: PCT/SG2011/000414. National phase: Europe (Appl. No.: 11 842 853.1), Singapore (Appl. No.: 201303178-6). Assigned Singapore Patent No. 190009. Granted: Patent No. 9,616,031
8. Targeted drug delivery to bone. NTU TD ref: TD/024/08 – US Provisional No. 61/184,548 filed 5 Jun 2009 (lapsed). PCT Application no. PCT/SG2010/000214 filed 7-Jun-2010. National phase: Singapore, China, Europe, India and USA (No. 13/375,713). Granted. China Patent Application No : 201080034589.7
  • Combinatorial Supplementation of Fish Feeds through Encapsulation for Enhanced Growth Rates in Aquaculture
  • Nanyang Education Award (College)
  • Retractable Guidewire Sensor to Replace X-ray Imaging for Nasogastric-tube Intubation in Both Acute-care and Homecare Nursing for the Elderly
  • Uncovering the Mechanical Coupling of Nanoparticle and Extracellular Matrix Elasticities for Enhanced Tumor Targeting
US 2018/0016618 A1 : Electrochemical Detection Of Microorganisms (2019)
Abstract: The present invention provides a method for determining the presence of a microorganism in a sample using an electrochemically active reporter, wherein the method comprises (a) contacting the sample with an electrochemically active reporter, wherein the electrochemically active reporter is a conjugate comprising a sugar moiety and a redox active reporter moiety that are covalently linked such that the covalent bond can be enzymatically cleaved in the presence of the microorganism by an enzyme expressed by the microorganism, wherein the redox active reporter moiety is selected from the group consisting of resorufin and compounds of formula (I) as defined herein, under conditions that allow enzymatic cleavage of the covalent bond between the sugar moiety and the redox active reporter moiety and reduction of the redox active report moiety in the presence of the microorganism; (b) electrochemically determining the released redox active reporter moiety; and (c) determining the presence of the microorganism and, optionally, number of the microorganisms in the sample based on the determined released redox active reporter moiety. Also encompassed are the electrochemically active reporters used in the described methods and their use for determination of the presence of microorganisms in a sample.

US 2013/0281977 A1: A Device For Controlled Release Of A Bioactive Agent (2017)
Abstract: Present invention relates to a device for controlled release of a bioactive agent. The device comprises a thin film located on the surface of the device, wherein said thin film comprises a bioactive agent-containing layer comprising a polymeric matrix and at least one bioactive agent.

US 2013/0302429 A1: Method For Encapsulating Particles (2017)
Abstract: The present invention relates to a method for encapsulating particles of a water-insoluble material within a capsule of a water-insoluble polymer, comprising (a) dispersing particles of the water-insoluble material or a solution containing the water-insoluble material in a first aqueous phase containing a first surfactant to obtain a first dispersion; (b) collecting the particles of the water-insoluble material coated with the first surfactant; (c) washing the collected particles; (d) adding the washed surfactant-coated water-insoluble material particles to a polymer solution containing the water-insoluble polymer of the capsule to obtain a polymer mixture; and (e) dispersing the polymer mixture in a second aqueous phase containing a second surfactant to obtain a second dispersion comprising the particles of the water-insoluble material encapsulated within the capsule of the water-insoluble polymer.

US 2015/0164815 A1: Floating Capsules Encapsulating Particles Loaded With One Or More Drugs (2016)
Abstract: The invention relates to capsules encapsulating particles loaded with one or more drugs, and in particular, to such capsules that are able to float. The capsules may be used for drug delivery in the gastrointestinal tract. Methods for forming the capsules are also disclosed, and in particular, double emulsion methods are used in forming the capsules.