Academic Profile

Dr. Koh Cheng Gee obtained her BSc(Hons) from the National University of Singapore and her PhD from the University of Cambridge, UK. She joined the School of Biological Sciences (NTU) in 2004 as Assistant Professor. She is currently Associate Professor and Associate Chair (Faculty) at the School of Biological Sciences.
cgkoh_1_2.JPG picture
Assoc Prof Koh Cheng Gee
Associate Chair (Faculty), School of Biological Sciences
Associate Professor, School of Biological Sciences

Our laboratory is interested in the signal transduction events involving small GTPases of the Rho family, their regulators and effectors. These proteins play key roles in transducing extracellular stimuli into distinct responses including cell shape changes, cell motility, adhesion, cell division and phagocytosis. The emphasis of our current research is on the kinase PAK, its interacting protein PIX and a family of serine/threonine phosphataes of the PP2C family, POPXs.
 
  • Characterization, in vitro and in vivo validation of local tropical herbs for colon cancer, stomach cancer and liver cancer prevention and treatment

  • Interaction of Living Matter with Oxide Thin films:potential Materials to prevent Bacterial Attachment

  • Mechanosenstive Responses Of Tumor Cells Under Compression

  • Regulation of Cell Signalling

  • Signal Transduction in Cancer Cells

  • The Regulation Of Focal Adhesions In Embryonic Stem Cells
 
  • Singh P, Gan CS, Guo T, Sze SK and Koh CG. (2011). Investigation of POPX2 phosphatase functions by comparative phosphoproteomic analysis. Proteomics, 11(14), 2891-2900.

  • Heng YW and Koh CG. (2010). Action Cytoskeleton Dynamics and the Cell Division Cycle. The International Journal of Biochemistry & Cell Biology, 42, 1622-1633.

  • Susila, A, Chan H, Loh AXW, HQ Phang, ET Wong, Tergaonkar V and Koh CG. (2010). POPX2 phosphatase regulates cancer cell motility and invasiveness. Cell Cycle, 9, 179-187.

  • Wong CH, Chan H, Ho CY, Lai SK, Chan KS, Koh CG* & Hoi-Yeung Li*. (2009). Apoptotic histone modification inhibits nuclear transport by regulating RCC1. Nature Cell Biology, 11, 36-45.

  • Xie Y, Tan EJ, Wee S, Manser E, Lim L, Koh CG. (2008). Functional interactions between phosphatase POPX2 and mDia modulate RhoA pathways. Journal of Cell Science, 121, 514-521.