Academic Profile

Dr. Wenting ZHAO obtained her bachelor's degree in Bioengineering from Zhejiang University (China) and Ph.D. from Hong Kong University of Science and Technology (HKUST). After completing her postdoc training at Stanford University, she joined Nanyang Technological University to start her own lab in the School of Chemical and Biomedical Engineering. Currently, her group aims to engineer the nanoscale organization of the biological systems and to uncover the nanoscale interplay between cells and the environment in both physiological and pathological conditions. Her research works have been published in Nature Nanotechnology, PNAS, Nano Letters, ACS Nano, Nature Protocols, Accounts of Chemical Research, Chemical Communications, etc.
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Asst Prof Zhao Wenting
Assistant Professor, School of Chemical and Biomedical Engineering

Dr. Zhao's research interest is at the nano-bio interplay with a particular focus on nanotechnology-enabled manipulation of cellular physical properties, and their impact on the fundamental understanding and therapeutic development of a variety of public health challenges, including cancer metastasis, viral infection, and neurodegeneration, etc.
 
  • A Novel Platform to Probe Cancer Malignancy via Mechanobiology: Targeting the Hardest Part Inside a Cancer Cell at Nanoscale

  • Engineering the Nanoscale Membrane Topography to Pattern Oncogenic Ras Clustering on Cell Membrane

  • Mechanobiology of podosomes: effects of mechanical stresses and substrate topography

  • Revealing Aging And Infectious Disease At Nanoscale: A Multidisciplinary Study Via Nanoscale Membrane Curvature Guidance
 
  • Su, M.; Zhuang, Y.; Miao, X.; Zeng, Y.; Gao, W.; Zhao, W.T. #; Wu, M. #. (# co-corresponding) Comparative study of curvature sensing mediated by F-BAR and an intrinsically disordered region of FBP17. iScience, 2020, 23 (11), 101712.

  • Yurugi, H.; Zhuang, Y.; Siddiqui, F.; Liang, H.; Rosigkeit, S.; Zeng, Y.; Abou-hamdan, H.; Bockamp, E.; Zhou, Y.; Abankwa, D.; Zhao, W.T.; Desaubry, L.; and Rajalingam, K.; A subset of flavaglines inhibits KRAS nanoclustering and activation, Journal of Cell Science, 2020, 133: jcs244111.

  • Lou, H.Y.*; Zhao, W. T.*; (* equal contribution) Li, X.; Duan, L.; Powers, A.; Akamatsu, M.; Santoro, F.; McGuire, A.F.; Cui, Y.; Drubin, D.G.; Cui, B.X., Membrane curvature underlies actin reorganization in response to nanoscale surface topography, Proceedings of the National Academy of Sciences, U. S. A., 2019, 116 (46), 23143-23151.

  • Liang, H., Mu, H., Jean-Francois, F,. Lakshman, B., Sarkar-Banerjee, S., Zhuang, Y., Zeng, Y., Gao, W., Zaske, A.M., Nissley, D.V., Gorfe, A.A., Zhao, W.T., Zhou, Y., Membrane curvature sensing of the lipid-anchored K-Ras small GTPase, Life Science Alliance, 2019, 2 (4), e201900343. (DOI: 10.26508/lsa.201900343)

  • Li, X., Matino L., Zhang, W., Klausen, L., McGuire, A., Lubrano, C., Zhao, W.T.#, Santoro, F.#, Cui, B.#, (# co-corresponding) A nanostructure platform for live cell manipulation of membrane curvature, Nature Protocols, 2019, 14, 1772–1802. (DOI: 10.1038/s41596-019-0161-7)

  • Chew, S.W.T.; Zeng, Y.; Cui, M.; Chang, H.; Zheng, M.; Wei, S.; Zhao W.T.#; Xu, C.J. #, (# co-corresponding) In situ generation of zinc oxide nanobushes on microneedles as antibacterial coating, SLAS Technology : Translating Life Sciences Innovation, 2019, 24 (2), 181-187.

  • Lou, H.Y.*; Zhao, W. T.*; (* equal contribution) Zeng, Y.; Cui, B. X., The role of membrane curvature in nanoscale topography-induced intracellular signaling. Accounts of Chemical Research, 2018, 51 (5), 1046–1053. (DOI: 10.1021/acs.accounts.7b00594)

  • Zhao, W. T.; Hanson, L.; Lou, H.Y.; Akamatsu, M.; Chowdary, P.; Santoro, F.; Marks, J.; Grassart, A.; Drubin, D. G., Cui, Y.; Cui, B. X., Nanoscale manipulation of membrane curvature for probing endocytosis in live cells. Nature Nanotechnology, 2017, 12, 750-756. (DOI: 10.1038/nnano.2017.98)

  • Santoro, F.; Zhao, W. T.; Joubert, L.-M.; Duan, L.; Schnitker, J.; van de Burgt, Y.; Liu, B.; Salleo, A.; Cui, Y.; Cui, B. X., Revealing the cell-material interface by FIB-SEM. ACS Nano, 2017, 11, (8), 8320-8328. (DOI: 10.1021/acsnano.7b03494)

  • Lou, H.Y.*; Zhao, W. T.*; (* equal contribution) Hanson, L.; Zeng, C.; Cui, Y.; Cui, B. X., Dual functional lipid coating on nanopillars for high purity and high efficiency capture of circulating tumor cells. Langmuir, 2017, 33, (4), 1097-1104. (DOI: 10.1021/acs.langmuir.6b03903)

  • Hanson, L.; Zhao, W. T.; Lou, H.Y.; Lin, Z. L.; Lee, S.W.; Chowdary, P.; Cui, Y.; Cui, B. X., Vertical nanopillars for in situ probing of nuclear mechanics in adherent cells. Nature Nanotechnology, 2015, 10, (6), 554-562. (DOI: 10.1038/NNANO.2015.88)

  • Xie, X.*; Zhao, W. T.*; (* equal contribution) Lee, H. R.; Liu, C.; Ye, M.; Xie, W. J.; Cui, B. X.; Criddle, C. S.; Cui, Y., Enhancing the Nanomaterial Bio-Interface by Addition of Mesoscale Secondary Features: Crinkling of Carbon Nanotube Films to Create Subcellular Ridges. ACS Nano, 2014, 8, (12), 11958-11965. (DOI: 10.1021/nn504898p)