Academic Profile : Faculty

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Prof Liu Xuewei
Professor, School of Chemistry, Chemical Engineering and Biotechnology
External Links
 
Associate Professor LIU Xuewei
Division of Chemistry and Biological Chemistry
School of Physical & Mathematical Sciences
College of Science
Nanyang Technological University
E-mail: xuewei@ntu.edu.sg

Professional Experiences
2012-now Associate Professor in Chemistry, NTU, Singapore
2006-2012 Assistant Professor in Chemistry, NTU, Singapore
2003-2005 Postdoctoral Research Fellow, California Institute of Technology
2002-2003 Senior Research Scientist, Chugai Pharma USA
2000-2002 Research Scientist, Proctor & Gamble Pharmaceuticals

Education
2003-2005 Postdoctoral Research Fellow, California Institute of Technology
2000 PhD in Chemistry, University of Southern California
1996 BSc and MSc in Chemistry, China Agricultural University, President Award

Awards and Honors
2012 The 7th Asian Core Program (ACP) Lectureship Award (to China)
2012 CoS Collaborative Research Award
2011 The 6th Asian Core Program (ACP) Lectureship Award (to Taiwan)
2011 The 6th Asian Core Program (ACP) Lectureship Award (to Korea)
2009 Young Researcher Award
2007 Excellent Presentation Award, Thailand
2006 The 1st Asian Core Program (ACP) Lectureship Award (to Japan)
1999 Liang Fellowship, University of Southern California
1998 President Research Fellowship, Nagoya University, Japan
Research Interests

The research program in our group integrates organic chemistry, chemical biology, medicinal chemistry and materials chemistry. A special emphasis is placed on training and research in carbohydrate synthesis and on the utilization of this expertise in addressing problems of medicinal and biochemical significance.

i. Carbohydrate chemistry
ii. Glycopeptide and glycoprotein synthesis
iii. Glycobiology
iv. Antimicrobial Research
v. Glycal-oriented synthesis of natural products
vi. Functional materials


Selected Publications (1 paper is selected from each year of 2011-2016)

Hua Chai‡, Kim Le Mai Hoang‡, Minh Duy Vu, Kalyan Pasunooti, Chuan-Fa Liu and Xue-Wei Liu#, “N-Linked Glycosyl Auxiliary-Mediated Native Chemical Ligation on Aspartic Acid: Application towards N-Glycopeptide Synthesis”, Angew. Chem. Int. Ed., 2016, 55, 10363-10367. Highlighted by X-MOL.

Shaohua Xiang, Kim Le Mai Hoang, Jingxi He, Yujia Tan and Xue-Wei Liu#, “Reversing the Stereoselectivity of a Palladium-Catalyzed O-Glycosylation through an Inner-Sphere or Outer-Sphere Pathway”, Angew. Chem. Int. Ed., 2015, 54, 604-607.

Kim Le Mai Hoang and Xue-Wei Liu#, “The Intriguing Dual-Directing Effect of 2-Cyanobenzyl Ether for Highly Stereospecific Glycosylation Reaction”, Nat. Commun., 2014, 5, 5051.

Jing Zeng, Jimei Ma, Shaohua Xiang, Shuting Cai, and Xue-Wei Liu#, “Stereoselective β-C-Glycosylation via Palladium-Catalyzed Decarboxylative Allylation: Formal Synthesis of Aspergillide A”, Angew. Chem. Int. Ed., 2013, 52, 5134-5137. Highlight in Synfacts 2013, 9, 870.

Bala Kishan Gorityala‡, Zhiqiang Lu‡, Min Li Leow, Jimei Ma, and Xue-Wei Liu#, “Design of a “Turn-off/Turn-on” Biosensor: Understanding Carbohydrate-lectin Interactions to Utilization in Noncovalent Drug Delivery”, J. Am. Chem. Soc., 2012, 134, 15229-15232.

Rujee Lorpitthaya, Sharad B. Suryawanshi, Siming Wang, Kalyan Kumar Pasunooti, Shuting Cai, Jimei Ma, and Xue-Wei Liu#, “Total Synthesis of Sialic Acids by a Sequential Rhodium-Catalyzed Azridination and Barbier Allylation of D-Glycal”, Angew. Chem. Int. Ed., 2011, 50, 12054-12057
 
  • A Simple and Scalable Synthesis of Homogenous N-Glycopeptide and N-Glycoprotein Drugs
  • An Environmentally Sustainable Method For Online Chemical Cleaning Of Membrane Bioreactor With Fe2+-Activated Peroxymonosulfate Towards Reduced Membrane Refouling
  • Multivalent glycoclusters: synthetic methods and applications in sugar-oriented drug delivery
  • Novel Antimalarial Cyclic Peptides and Enzymes from an Unusual Biosynthetic Pathway
  • Phosphorus Ylides: New Activation Mode and Olefin Synthesis
  • Study of Foxing on Watercolor Paper and its Prevention
  • Understanding the Role of Transglycosylase in Bacterial Cell Wall Synthesis
US 2013/0079520 A1: A Method To Synthesize Anatase TiO2 Nanosheets (2017)
Abstract: A method of synthesizing anatase TiO2 nanosheets, the method comprising the steps of: (a) mixing a titanium complex with an ethanolamine derivative; (b) adding water to form a mixture; and (c) heating the mixture at a temperature ranging from about 150° C. to about 200° C. to obtain anatase TiO2 nanosheets having O-terminated {100} facets.

US 2013/0084239 A1: Method of Preparing A TiO2 Nanostructure (2017)
Abstract: The present invention discloses a method preparing a TiO2 nanostructure comprising: mixing an organic acid and an aminoalcohol to form an ionic liquid; heating the ionic liquid with titanium ions and lithium ions to form a layered structure; and annealing the mixture to form the TiO2 nanostructure. There is also provided uses of the prepared nanostructure.

US 2015/0014582 A1: An Anode Material For Ultrafast-Charging Lithium Ion Batteries And A Method Of Its Synthesis (2015)
Abstract: An anode material for ultrafast-charging lithium ion batteries, the anode material comprising C—Li4Ti5O12. A method of synthesizing an anode material for ultrafast-charging lithium ion batteries, the method comprising the steps of: adding lithium to an organic alcohol to form a first solution; adding titanium via an organic titanium source to the first solution to form a second solution; adding water to the second solution to form a diluted second solution; heating the diluted second solution at a temperature ranging from about 80° C. to about 180° C. to obtain solid Li4Ti5O12; and annealing the solid Li4Ti5O12 in the absence of air to obtain the anode material comprising C—Li4Ti5O12..

US 2020/0038352 A1: Co-Crystals Of NURR1-LBD In Complex With A Cyclopentenone Prostaglandin And Modulators Of NURR1 (2022)
Abstract: Co-crystals comprising the Nuclear receptor related 1 protein-ligand binding domain (Nurr1-LBD) and a cyclopentenone prostaglandin are provided. Also provided are methods of identifying or designing Nurr1-modulating ligands and compounds based on the crystal structures described herein as well as the applications of said ligands and compounds as Nurr1 modulators or medicaments.