Academic Profile

Academic Qualifications
1994-1997 Doctor of Philosophy, National University of Singapore

Current Position
Associate Professor, Lee Kong Chian School of Medicine.
Joint appointment with School of Biological Sciences, NTU, Singapore

Awards
2014 The Commendation Medal (Prime Minister’s Office)
2013 Nanyang Education Award (College)
2012 Nanyang Award for Research Excellence
Andrew-1.jpg picture
Assoc Prof Tan Nguan Soon
Associate Professor, Metabolic Disorders and Vice Dean (Faculty Affairs)
Associate Professor, Lee Kong Chian School of Medicine
Associate Professor of Metabolic Disorders, School of Biological Sciences (SBS)
Provost's Chair in Metabolic Disorder, Lee Kong Chian School of Medicine (LKCMedicine)

The overaching theme of my research interest is understanding OXIDATIVE STRESS IN DISEASE PROGRESSION.

METABOLIC DISEASES (Nonalcoholic fatty liver disease, NAFLD)
NAFLD is an impending epidemic that affects 25% of the population worldwide. There is no FDA-approved treatment for NASH. Oxidative stress plays a central role in the pathogenesis of NAFLD. We have developed a novel NAFLD model that recapitulates the various transitory stages of human NAFLD and extrahepatic comorbidities. We are currently investigating the relationship between gut microbes and the redox imbalance in the liver.

TARGETING METASTASIS
Metastasis accounts for more than 90% of cancer mortality. Once metastasis occurs, surgical excision of the primary tumor no longer guarantees disease free survival and the probability of cancer relapse in distal organs increases significantly. Our findings have established several paradigms in oxidative stress-driven metastasis. Our current interest aims to decipher the mechanisms that regulate and coordinate the different networks during metastasis.

WOUND HEALING
Poor healing wounds represent a silent epidemic that affects a large fraction of the world population and carries a heavy socioeconomic burden. A balanced redox state is critical for proper healing. A highly oxidative wound microenvironment, often observed in diabetic wounds, delays wound healing.
Effective management of these problems will require better understanding of the healing process to allow the creation of a salubrious environment conducive to healing. Our lab has worked extensively to understand the interplay among different cell types, contributing to redox imbalance, in poor healing wounds.
 
  • Bedside to bench and back again: evaluating Neisseria spp.as novel respiratory pathobionts using systems biology

  • Bioactive Stem Cells Secretome-Enriched Hydrogels For Chronic Wound Healing

  • Portable SERS-based Breathalyzer for Rapid and Online COVID-19 Detection and Surveillance (Phase 2)

  • Relaxin treatment of liver fibrosis and vascular dysfunction using a novel animal model of non-alchoholic steatohepatits

  • Role of angiopoietin-like 4 in nonalcoholic steatohepatitis progression.

  • Targeting Brain Tumors: Improving Lives Through Precision Medicine
 
  • Cheng, H.S., Marvalim, C., Zhu, P.C., Law, C.L.D., Low, Z.Y.J., Chong, Y.K., Ang, B.T., Tang, C. and Tan, N.S. (2021) Kinomic profile in patient-derived glioma-propagating cells during hypoxia reveals c-MET-PI3K dependency for adaptation. Theranostics 11(11):5127-5142

  • Shin, E.M., Huynh, V.T., Neja, S.A., Liu, C.Y., Raju, A., Tan, K., Tan, N.S., Gunaratne, J., Bi, X., Iyer, L.M., Aravind, L., and Tergaonkar, V. GREB1: an evolutionarily conserved inducible mammalian cytoplasmic O-GlcNAc glycosyltransferase links hormone receptor stability to cancer. Science Advances 7(12):eabe2470

  • Suzuki, T., Ishii, S., Shinohara, M., Kawano, Y., Wakahashi, K., Kawano, H., Sada, A., Minagawa, K., Hamada, M., Takahashi, S., Furuyashiki, T., Tan, N.S., Matsui, T., Katayama, Y. (2020). Mobilization efficiency is critically regulated by fat via marrow PPARδ in mice. Haematologica. 106(6):1671-1683. doi: 10.3324/haematol.2020.26575.

  • Tan, M.W.I., Tan, W.R., Kong, Z.Q., Toh, J.H., Wee, W.K.J., Teo, E.M.L., Cheng, H.S., Wang, X.M. and Tan, N.S. (2020). High glucose restrains acetylcholine-induced keratinocyte EMT is mitigated by p38 inhibition. J. Invest. Dermatol. DOI: 10.1016/j.jid.2020.10.026

  • Zhang, Y., Liu, M., Peng, B., Jia, S., Koh, D., Wang, Y., Cheng, H.S., Tan, N.S., Warth, B., Chen, D., Fang, ML. (2020) Impact of Mixture Effects between Emerging Organic Contaminants on Cytotoxicity: A Systems-Biological Understanding of Synergism between TDCPP and TPP. Environ. Sci. Technol. Sep 1;54(17):10722-10734. doi: 10.1021/acs.est.0c02188

  • Wu, Z., Lim, H.K., Tan, S.J., Gautum, A., Hou, H.W., Ng, K.W., Tan, N.S. and Tay, C.Y. (2020) Potent-by-design: amino acids mimicking porous nanotherapeutics with intrinsic anti-cancer targeting properties. Small Aug;16(34):e2003757. doi: 10.1002/smll.202003757.

  • Jung, K.H., Sonm M.K., Yan, H.H., Fang, Z., Kim, J.Y., Kim, S.J., Park, J.H., Lee, J.E., Yoon, Y-C., Seo, M.S., Han, B.S., Ko, S., Lim, J.H., Lee, D-H., Teo, Z., Wee, W.K.J., Tan, N.S.* and Hong, S-S.* (2020) ANGPTL4 exacerbates pancreatitis by augmenting acinar cell injury through upregulation of C5a. EMBO Mol. Med. Aug 7;12(8):e11222. doi: 10.15252/emmm.201911222. co-corresponding

  • Kao, Y-C., Han, X., Lee, Y.H., Lee, H.K., Phan, G.C., Lay, C.L., Sim, H.Y.F., Ku, C.W., Tan, T.C., Tan, N.S.* and Li, X.Y.* (2020). SERS-based Metabolomics for Rapid and Non-invasive Diagnosis of Spontaneous Miscarriage. ACS Nano (DOI: 10.1021/acsnano.0c00515) *co-corresponding

  • Li, L., Foo, B., Kwok, K.W., Sakamoto, N., Mukae, H., Izumikawa, H., Mandard, S., Quenot, J-P., Lagrost, L., Teh, W.K., Kohli, G.S., Zhu, P.C., Choi, H., Buist, M., Seet, J.E., Yang, L., He, F., Chow, V. and Tan, N.S. (2019) Antibody treatment against angiopoietin-like 4 reduces pulmonary edema and injury in secondary pneumococcal pneumonia. mBio 10:e02469-18.

  • Cheng, H.S., Lee, J.X.T., Wahli, W. and Tan, N.S. (2019) Exploiting vulnerabilities of cancer by targeting nuclear receptors of stromal cells in tumor microenvironment. Mol. Cancer Mar 30;18(1):51. doi: 10.1186/s12943-019-0971-9.

  • Liao, Z., Chua, D. and Tan, N.S. (2019) Reactive oxygen species: a volatile driver of field cancerization and metastasis. Mol. Cancer Mar 30;18(1):65. doi: 10.1186/s12943-019-0961-y

  • Lim, M.M.K., Wee, J.W.K.,Soong, J.C., Chua, D., Tan, W.R., Lizwan, M., Li, Y., Teo, Z., Goh, W.W.B., Zhu, P.C. and Tan, N.S. (2018) Targeting metabolic flexibility via angiopoietin-like 4 protein sensitizes metastatic cancer cells to chemotherapy drugs. Mol. Cancer 17(1):152. doi: 10.1186/s12943-018-0904-z.

  • Lim, H.Y., Lim S.Y., Tan, C.K., Goh, C.C., See, P., Chakarov, S., Carbajo, D., Wang, X.N., Lim, L.H., Thiam, C.H., Johnson, L.A., Basu, R., Yeo, K.P., Chew, S.H.S., Goh, C., Evrard, M., Wang, J.K., Tan, Y., Jain, R., Tikoo, S., Jackson, D.G., Choong, C., Weninger, W., Poidinger, M., Stanley, R.E., Collin, M., Tan, N.S., Ng, L.G., Ginhoux, F. and Angeli, V. (2018). Hyaluronan receptor LYVE-1 expressing macrophages maintain arterial tone through hyaluronan-mediated regulation of smooth muscle cell collagen. Immunity. 49(2):326-341.e7. doi: 10.1016/j.immuni.2018.06.008.

  • Tan, E.H.P., Sng, M.K., How, I.S.B., Chan, J.S.K., Chen, J., Tan, C.K., Wahli, W. and Tan, N.S. (2018) ROS release by PPAR/δ-null fibroblasts reduces tumor load through epithelial antioxidant response. Oncogene doi:10.1038/s41388-017-0109-8

  • Chan, J.S.K., Sng, M.K., Teo, Z.Q., Chong, H.C., Twang, J.S. and Tan, N.S. (2018) Targeting nuclear receptors in cancer-associated fibroblasts as concurrent therapy to inhibit development of chemoresistant tumors. Oncogene 37(2):160-173. doi: 10.1038/onc.2017.319