Academic Profile : Faculty
Assoc Prof Tan Thatt Yang Timothy
Associate Professor, School of Chemistry, Chemical Engineering and Biotechnology
Deputy Director, CN Yang Scholars Programme, CN Yang Scholars Programme
Email
PhD (Chemical Engineering), Feb 2004 – University of New South Wales, Australia.
Thesis “Photocatalytic Reduction of Selenate and Selenite: Water/Wastewater treatment and the Formation of Nano-Selenium Compounds” under the International Postgraduate Research Awards (IPRS), Australia.
Thesis “Photocatalytic Reduction of Selenate and Selenite: Water/Wastewater treatment and the Formation of Nano-Selenium Compounds” under the International Postgraduate Research Awards (IPRS), Australia.
1. Nanomedicine: Design and Engineering of Multifunctional Nanomaterials for simultaneous targeting, bio-imaging and drug delivery.
The research objective of this work is to apply nanotechnology to medicine. We have developed a new class of florescent-magnetic nanoparticles as probes and aim to demonstrate their application in both fluorescent microscopy and MRI. Subsequent work will be undertaken to introduce multifunctional organic, organometallic or biological groups into nanostructured materials to render them with biocompatibility, targeting, drug loading and delivery functions. The cytotoxicity of such nanomaterial will also be evaluated.
2. Design of Nanoparticles for Drug Separation.
The project focuses on the development of nano-sized achiral and chiral packing materials for Super-critical fluid Chromatography (SFC), Capillary Electrophoresis (CE) and Capillary Electrochromatography (CEC). Judging from the viewpoint of novelty of science, there are to date no known research work published in open literature on the application of chiral-nanomaterials having size ranging < 1.5 ?m for SFC, CE and CEC analyses. The reduction in size of packing materials is anticipated to lead to a huge increase in chromatographic resolution.
3. Advanced Materials for Green Architecture: Nanocomposites for Permanent Self-cleaning and Antibacterial Surface.
This research focuses on synthesizing scratch resistant nanocomposite coating that are photocatalytic, superhydrophilic and antibacterial. This material can then be coated to surfaces inside and outside buildings and structures for permanent self-cleaning and antibacterial functions. Current work includes exploring various synthesis methods (including atomic deposition, sonication and sol-gel) that will give the most efficient materials.
The research objective of this work is to apply nanotechnology to medicine. We have developed a new class of florescent-magnetic nanoparticles as probes and aim to demonstrate their application in both fluorescent microscopy and MRI. Subsequent work will be undertaken to introduce multifunctional organic, organometallic or biological groups into nanostructured materials to render them with biocompatibility, targeting, drug loading and delivery functions. The cytotoxicity of such nanomaterial will also be evaluated.
2. Design of Nanoparticles for Drug Separation.
The project focuses on the development of nano-sized achiral and chiral packing materials for Super-critical fluid Chromatography (SFC), Capillary Electrophoresis (CE) and Capillary Electrochromatography (CEC). Judging from the viewpoint of novelty of science, there are to date no known research work published in open literature on the application of chiral-nanomaterials having size ranging < 1.5 ?m for SFC, CE and CEC analyses. The reduction in size of packing materials is anticipated to lead to a huge increase in chromatographic resolution.
3. Advanced Materials for Green Architecture: Nanocomposites for Permanent Self-cleaning and Antibacterial Surface.
This research focuses on synthesizing scratch resistant nanocomposite coating that are photocatalytic, superhydrophilic and antibacterial. This material can then be coated to surfaces inside and outside buildings and structures for permanent self-cleaning and antibacterial functions. Current work includes exploring various synthesis methods (including atomic deposition, sonication and sol-gel) that will give the most efficient materials.
- Capability building of a GLP-ready oligonucleotide synthesis and conjugation process with established workflow and validation of siRNA performance (NATiOligoSYN)
- Demonstrating evidence-based value for medical siRNA scar-prevention patch
- Pathogenesis and novel preventive treatment of pathological cutaneous scarring: role of SPARC and TH2 immunological milieu and treatment with siRNA-embedded dissolving microneedles
US 2019/0388883 A1: Multi-Layered Metal-Carbon Materials-Based Nanoarchitectures (2022)
Abstract: Disclosed herein is a multi-layered composite thin film material formed from graphene quantum dots (GQDs) and metal nanocrystals in a layer-by-layer design, wherein the metal nanocrystals can be selected from the group consisting of Ru, Rh, Os, Ir, Pd, Au, Ag and Pt. In a preferred embodiment, the multi-layered composite thin film material is prepared via a facile, green, and easily accessible layer-by-layer (LbL) self-assembly strategy. In this strategy, positively charged GOQDs and negatively charged metal nanocrystals are alternately and uniformly integrated with each other in a “face-to-face” stacked fashion under substantial electrostatic attractive interaction, and then the obtained GOQDs/metal composite thin film is calcined into GQDs/metal composite thin film. The composite thin film material disclosed herein may be used to catalyse a wide range or reactions, including selective reduction of aromatic nitro compounds in water and electrocatalytic oxidation of methanol at ambient conditions.
Abstract: Disclosed herein is a multi-layered composite thin film material formed from graphene quantum dots (GQDs) and metal nanocrystals in a layer-by-layer design, wherein the metal nanocrystals can be selected from the group consisting of Ru, Rh, Os, Ir, Pd, Au, Ag and Pt. In a preferred embodiment, the multi-layered composite thin film material is prepared via a facile, green, and easily accessible layer-by-layer (LbL) self-assembly strategy. In this strategy, positively charged GOQDs and negatively charged metal nanocrystals are alternately and uniformly integrated with each other in a “face-to-face” stacked fashion under substantial electrostatic attractive interaction, and then the obtained GOQDs/metal composite thin film is calcined into GQDs/metal composite thin film. The composite thin film material disclosed herein may be used to catalyse a wide range or reactions, including selective reduction of aromatic nitro compounds in water and electrocatalytic oxidation of methanol at ambient conditions.
Courses Taught
CH1104 Materials & Energy Balances
CH1801 Chemical & Biomolecular Engineering Laboratory 1A
CH2801 Chemical & Biomolecular Engineering Laboratory 2A
CH3802 Chemical & Biomolecular Engineering Laboratory 5
CH7101 Nanotechnology & Its Applications
CH1801 Chemical & Biomolecular Engineering Laboratory 1A
CH2801 Chemical & Biomolecular Engineering Laboratory 2A
CH3802 Chemical & Biomolecular Engineering Laboratory 5
CH7101 Nanotechnology & Its Applications