Academic Profile

Dr. Yu-Cheng Chen received M.S in Optoelectronics from National Taiwan University in 2012. From 2012-2015, he worked as a research associate at the Molecular Imaging Center at NTU Hospital, Taipei. He then received a PhD degree in Biomedical Engineering from the University of Michigan, Ann Arbor in 2017 and became the first student to accomplish PhD degree within two years in the school history. Later he joined Nanyang Technological University, Singapore upon receiving the prestigious Nanyang Assistant Professorship Award in 2018, being as one of the youngest faculty in the college. His research focused mainly on the development of novel bio-lasers, from molecular, cellular, to tissue level, which is an emerging field for next generation biomedical applications. Since 2012 he has already published more than 40 journals and proceedings, including Nature Biomedical Engineering, Optica, while a start-up company is being formed to market the optofluidic biolaser technology based on his pioneer work in PhD. His research was reported by more than 30 media and news worldwide, including "Nature Reviews", “The New Scientists”, “RSC-Chemistry World”, “Daily Mail”, “BioOptics World”, “Phys. Org.”, etc. Being as the pioneer in the field of Biolasers, he has achieved several breakthroughs, including several types of biolasers at the tissue level, which pointed out future direction using lasing emission for on-chip disease diagnosis and cancer detection. Most importantly, he invented the first laser-emission microscopy, a novel imaging modality that can be widely applied to bio-devices, cancer immunodiagnostics, and neuro-analysis. These breakthroughs represent a critical milestone to implement biolasers in biomedical imaging, which opens a door to a plethora of applications in translation research of laser-emission microscopy, precision medicine and fundamental biology.

His research mainly focuses in optofluidics, biolasers, biophotonics, biosensors and imaging, nanophotonics, neural-engineering, and novel on-chip laser devices. Currently, he is a Nanyang Assistant Professor at NTU in Singapore. He is affiliated with EEE/SCBE.

Biolasers is an innovative and emerging area which promises a plethora of opportunities for the next generation biomedical detection/ imaging and nanophotonics. This is an entirely new field which welcomes expertise of all backgrounds, many exciting topics can be explored!
That includes the development of advanced lasing imaging system/ integrated point-of-care devices, as well as the fundamental science of lasers at the single molecular level up to biological networks. This cutting-edge research will build close collaborations with SCBE, EEE, medical school, and industry, but also many fields involving nanotechnology, computational analysis, machine learning, micro-electronics, synthetic biology, and translational medicine.

Currently we do not have any positions for postdocs and new PhD students.

Lab Homepage:
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Asst Prof Yu-Cheng, Chen
Nanyang Assistant Professor, School of Chemical and Biomedical Engineering
Nanyang Assistant Professor, School of Electrical & Electronic Engineering

1. Optofluidics, Bio-lasers, Micro-resonators;
2. Biophotonics, Biomedical imaging and biosensing;
3. Medical devices, Cellular and tissue diasgnosis;
4. Nanophotonics, Plasmonics, Nanolasers;
5. Neurophotonics, Neural-engineering, Novel on-chip laser devices
6. Bio-intelligent, Bio-integrated optical devices/robotics
  • Boosting Bioinspired Energy in Coupled Nanocavity: Transforming Biotrash to Bioelectricity

  • Development of Multifunctional Biolaser Emission Imaging for Highly-Sensitive Cancer and Neurological Tissue Analysis

  • Exosome Laser Biochip: Nanolasers for Multiplexed Cancer Analysis
  • Yuan Z., Wang Z., Guan P., Chen Y.C*. (2020). Lasing‐Encoded Microsensor Driven by Interfacial Cavity Resonance Energy Transfer. Advanced Optical Materials, 8 (7), 1901596.

  • Tan X., Chen Q., Zhu H., Chen Y.C., Fan X. (2019). A Fast and Reproducible ELISA Laser Platform for Ultrasensitive Protein Quantification. ACS Sensors, 5, 110-117.

  • Chen Y.C.*, Fan X. (2019). Biological Lasers for Biomedical Applications. Advanced Optical Materials, 7 (17), 1900377.

  • X. Li, Y. Chin, X. Tan, Y.-C. Chen, Q. Chen, X. Wang, and X. Fan. (2019). Ultrasound Modulated Droplet Lasers. ACS Photonics, 6(2).

  • Y.-C. Chen, X. Tan, A. Nadeem, Q. Chen, I. Bergin, and X. Fan. (2019). Chromatin Laser Imaging Reveals Abnormal Nuclear Changes for Early Cancer Detection. Biomedical Optics Express, 10, 838-854.