Academic Profile : Faculty
Assoc Prof Guillaume Thibault
Assistant Dean (International Engagement), College of Science, School of Biological Sciences
Associate Professor, School of Biological Sciences
Assistant Dean (International Engagement), College of Science
Email
External Links
Journal Articles
(Not applicable to NIE
staff as info will be
pulled from PRDS)
(Not applicable to NIE
staff as info will be
pulled from PRDS)
M.R. Kumar, K.R. Arulprakasam, A.N. Kutevska, M. Mutwil✉, Guillaume Thibault✉; Yeast Knowledge Graphs Database for Exploring Saccharomyces cerevisiae and Schizosaccharomyces pombe. Journal of Molecular Biology. 15 Mar 2024, doi: 10.1016/j.jmb.2025.169072.
R.A.G. da Silva, B.Y.Q. Tien, P.H.N. Kao, C. Celik, A.Z.C. Tan, M.H. Ismail, G. Hu, K.K.L. Chong, Guillaume Thibault, J. Chen, K.A. Kline✉; Enterococcus faecalis-derived lactic acid facilitates persistent and polymicrobial wound infections by suppressing macrophage activation. bioRxiv. 31 Jan 2025, doi: 10.1101/2025.01.31. 635924.
Karthick Raja Arulprakasam, Jenella Wing Shan Toh, Herman Foo, Mani R Kumar, An-Nikol Kutevska, Emilia Emmanuelle Davey, Marek Mutwil✉, Guillaume Thibault✉. Harnessing full-text publications for deep insights into C. elegans and Drosophila biomaps. BMC Genomics. 13 Nov 2024. doi: 10.1186/s12864-024-10997-6.
Cenk Celik, Stella Yue Ting Lee, Frederick Reinhart Tanoto, Mark Veleba, Kimberly A. Kline✉, Guillaume Thibault✉. Decoding the complexity of delayed wound healing following Enterococcus faecalis infection. eLife. 20 May 2024. doi: 10.7554/eLife.95113.3.
Kevin Fo, Yu Song Chuah, Herman Fyh, Emilia Emmanuelle Davey, Melissa Fullwood, Guillaume Thibault, Marek Mutwil✉. PlantConnectome: knowledge networks encompassing >100,000 plant article abstracts. bioRxiv. 11 Jul 2023. doi: 10.1101/2023.07.11.548541.
Cenk Celik, Stella Yue Ting Lee, Wei Sheng Yap, Guillaume Thibault✉. Endoplasmic reticulum stress and lipids in health and diseases. Prog Lipid Res. Jan 2023. doi: 10.1016/j.plipres.2022.101198.
R. Dudkevich, Jhee Hong Koh, Caroline Beaudoin-Chabot, Cenk Celik, I. Lebenthal-Loinger, S. Karato-Lampert, Syed Ahmad-Albukhari, Guillaume Thibault, S. Henis-Korenblit. Neuronal IRE-1 coordinates an organism-wide cold stress response by regulating fat metabolism. Cell Rep. 29 Nov 2022. doi: 10.1016/j.celrep.2022.111739.
Caroline Beaudoin-Chabot, Lei Wang, Cenk Celik, Aishah T.F. Abdul Khalid, Subbash Thalappilly, Shiyi Xu, Jhee Hong Koh, Venus W.X. Lim, Ann Don Low, and Guillaume Thibault✉. The unfolded protein response reverses the effects of glucose on lifespan in chemically-sterilized C. elegans. Nat Commun. 19 Oct 2022. doi: 10.1038/s41467-022-33630-0.
Wei Sheng Yap, Guillaume Thibault✉. Human PERK rescues unfolded protein response-deficient yeast cells. microPublication Biology. 22 Jun 2022. doi: 10.17912/micropub.biology.000592.
N. Ho, W.S. Yap, Guillaume Thibault✉. A high-throughput genetic screening method to measure lipid bilayer stress-induced UPR in Saccharomyces cerevisiae. STAR Protocols. 17 Dec 2021 doi: 10.1016/j.xpro.2021.100868.
K. Rizzolo, A.Y.H. Yu, A. Ologbenla, S.R. Kim, H. Zhu, K. Ishimori, Guillaume Thibault, E. Leung, Y.W. Zhang, M. Teng, M. Haniszewski, N. Miah, S. Phanse, Z. Minic, S. Lee, J.D. Caballero, M. Babu, F.T.F. Tsai, T. Saio, W.A. Houry. Functional cooperativity between the trigger factor chaperone and the ClpXP proteolytic complex. Nat Commun 2021 Jan 12. doi. 10.1038/s41467-020-20553-x
Wei Sheng Yap, Peter Shyu Jr., Maria Laura Gaspar, Stephen A. Jesch, Charlie Marvalim, William A. Prinz, Susan A. Henry, Guillaume Thibault✉. The yeast FIT2 homologs are necessary to maintain cellular proteostasis and membrane lipid homeostasis. J Cell Sci 2020 Nov 5. doi. 10.1242/jcs.248526
Nurulain Ho, Wei Sheng Yap, Jiaming Xu, Haoxi Wu, Jhee Hong Koh, Wilson W.B. Goh, Bhawana George, Shu Chen Chong, Stefan Taubert, Guillaume Thibault✉. Stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress. J Cell Biol 2020 Apr 29. doi. 10.1083/jcb.201909165
Xiu Hui Fun and Guillaume Thibault✉. Lipid bilayer stress and proteotoxic stress-induced unfolded protein response deploy divergent transcriptional and non-transcriptional programmes. Biochim Biophys Acta, Mol Cell Biol Lipids 2020 Jan doi. 10.1016/j.bbalip.2019.04.009
Sarita Hebbar, Elisabeth Knust, Guillaume Thibault✉, Rachel Kraut✉. Editorial: Connections to Membrane Trafficking Where You Least Expect Them: Diseases, Dynamics, Diet and Distance. Front Cell Dev Biol 2019 Dec 6. doi. 10.3389/fcell.2019.00327
Wilson W.B. Goh, Subhash Thalappilly, Guillaume Thibault✉. Moving beyond the current limits of data analysis in longevity and healthy lifespan studies. Drug Discov Today 2019 Dec. doi. 10.1016/j.drudis.2019.08.008
Kizito Njah, Sayan Chakraborty, Beiying Qiu, Surender Arumugam, Anandhkumar Raju, Ajaybabu V. Pobbati, Manikandan Lakshmanan, Vinay Tergaonkar, Guillaume Thibault, Xiaomeng Wang, Wanjin Hong. A Role of Agrin in Maintaining the Stability of Vascular Endothelial Growth Factor Receptor-2 during Tumor Angiogenesis. Cell Rep 2019 Jul 23. doi. 10.1016/j.celrep.2019.06.036
Peter Shyu Jr, Benjamin S.H. Ng, Nurulain Ho, Ruijie Chaw, Yi Ling Seah, Charlie Marvalim, Guillaume Thibault✉. Membrane phospholipid alteration causes chronic ER stress through early degradation of homeostatic ER-resident proteins. Sci Rep 2019 Jun 14. doi. 10.1038/s41598-019-45020-6
Caroline Beaudoin-Chabot, Lei Wang, Alexey V. Smarun, Dragoslav Vidovic, Mikhail S. Shchepinov, Guillaume Thibault. Deuterated polyunsaturated fatty acids reduce oxidative stress and extend the lifespan of C. elegans. Front Physiol 2019 May 28. doi. 10.3389/fphys.2019.00641
Jhee Hong Koh, Lei Wang, Caroline Beaudoin-Chabot, Guillaume Thibault. Lipid bilayer stress-activated IRE-1 modulates autophagy during endoplasmic reticulum stress. J Cell Sci 2018 Nov 21. doi. 10.1242/jcs.217992
Peter Shyu Jr, Xing Fah Wong, Karen Crasta, Guillaume Thibault. Dropping in on lipid droplets: insights into cellular stress and cancer. Biosci Rep 2018 Sep 19, 38(5). doi.10.1042/BSR20180764
Nurulain Ho, Chengchao Xu, Guillaume Thibault✉. From the unfolded protein response to metabolic diseases - lipids under the spotlight. J Cell Sci 2018 Feb 8;131(3). doi. 10.1242/jcs.199307
Chengchao Xu, Songyu Wang, Guillaume Thibault, Davis T. Ng. Futile Protein Folding Cycles in the ER Are Terminated by the Unfolded Protein O-Mannosylation Pathway. Science 340, 978-981. doi. 10.1126/science.1234055
Guillaume Thibault , Guanghou Shui, Woong Kim, Graeme C. McAlister, Nurzian Ismail, Steven P. Gygi, Markus R. Wenk, Davis T. Ng. The membrane stress response buffers lethal effects of lipid disequilibrium by reprogramming the protein homeostasis network. Mol Cell 48, 16-27. doi. 10.1016/j.molcel.2012.08.016
R.A.G. da Silva, B.Y.Q. Tien, P.H.N. Kao, C. Celik, A.Z.C. Tan, M.H. Ismail, G. Hu, K.K.L. Chong, Guillaume Thibault, J. Chen, K.A. Kline✉; Enterococcus faecalis-derived lactic acid facilitates persistent and polymicrobial wound infections by suppressing macrophage activation. bioRxiv. 31 Jan 2025, doi: 10.1101/2025.01.31. 635924.
Karthick Raja Arulprakasam, Jenella Wing Shan Toh, Herman Foo, Mani R Kumar, An-Nikol Kutevska, Emilia Emmanuelle Davey, Marek Mutwil✉, Guillaume Thibault✉. Harnessing full-text publications for deep insights into C. elegans and Drosophila biomaps. BMC Genomics. 13 Nov 2024. doi: 10.1186/s12864-024-10997-6.
Cenk Celik, Stella Yue Ting Lee, Frederick Reinhart Tanoto, Mark Veleba, Kimberly A. Kline✉, Guillaume Thibault✉. Decoding the complexity of delayed wound healing following Enterococcus faecalis infection. eLife. 20 May 2024. doi: 10.7554/eLife.95113.3.
Kevin Fo, Yu Song Chuah, Herman Fyh, Emilia Emmanuelle Davey, Melissa Fullwood, Guillaume Thibault, Marek Mutwil✉. PlantConnectome: knowledge networks encompassing >100,000 plant article abstracts. bioRxiv. 11 Jul 2023. doi: 10.1101/2023.07.11.548541.
Cenk Celik, Stella Yue Ting Lee, Wei Sheng Yap, Guillaume Thibault✉. Endoplasmic reticulum stress and lipids in health and diseases. Prog Lipid Res. Jan 2023. doi: 10.1016/j.plipres.2022.101198.
R. Dudkevich, Jhee Hong Koh, Caroline Beaudoin-Chabot, Cenk Celik, I. Lebenthal-Loinger, S. Karato-Lampert, Syed Ahmad-Albukhari, Guillaume Thibault, S. Henis-Korenblit. Neuronal IRE-1 coordinates an organism-wide cold stress response by regulating fat metabolism. Cell Rep. 29 Nov 2022. doi: 10.1016/j.celrep.2022.111739.
Caroline Beaudoin-Chabot, Lei Wang, Cenk Celik, Aishah T.F. Abdul Khalid, Subbash Thalappilly, Shiyi Xu, Jhee Hong Koh, Venus W.X. Lim, Ann Don Low, and Guillaume Thibault✉. The unfolded protein response reverses the effects of glucose on lifespan in chemically-sterilized C. elegans. Nat Commun. 19 Oct 2022. doi: 10.1038/s41467-022-33630-0.
Wei Sheng Yap, Guillaume Thibault✉. Human PERK rescues unfolded protein response-deficient yeast cells. microPublication Biology. 22 Jun 2022. doi: 10.17912/micropub.biology.000592.
N. Ho, W.S. Yap, Guillaume Thibault✉. A high-throughput genetic screening method to measure lipid bilayer stress-induced UPR in Saccharomyces cerevisiae. STAR Protocols. 17 Dec 2021 doi: 10.1016/j.xpro.2021.100868.
K. Rizzolo, A.Y.H. Yu, A. Ologbenla, S.R. Kim, H. Zhu, K. Ishimori, Guillaume Thibault, E. Leung, Y.W. Zhang, M. Teng, M. Haniszewski, N. Miah, S. Phanse, Z. Minic, S. Lee, J.D. Caballero, M. Babu, F.T.F. Tsai, T. Saio, W.A. Houry. Functional cooperativity between the trigger factor chaperone and the ClpXP proteolytic complex. Nat Commun 2021 Jan 12. doi. 10.1038/s41467-020-20553-x
Wei Sheng Yap, Peter Shyu Jr., Maria Laura Gaspar, Stephen A. Jesch, Charlie Marvalim, William A. Prinz, Susan A. Henry, Guillaume Thibault✉. The yeast FIT2 homologs are necessary to maintain cellular proteostasis and membrane lipid homeostasis. J Cell Sci 2020 Nov 5. doi. 10.1242/jcs.248526
Nurulain Ho, Wei Sheng Yap, Jiaming Xu, Haoxi Wu, Jhee Hong Koh, Wilson W.B. Goh, Bhawana George, Shu Chen Chong, Stefan Taubert, Guillaume Thibault✉. Stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress. J Cell Biol 2020 Apr 29. doi. 10.1083/jcb.201909165
Xiu Hui Fun and Guillaume Thibault✉. Lipid bilayer stress and proteotoxic stress-induced unfolded protein response deploy divergent transcriptional and non-transcriptional programmes. Biochim Biophys Acta, Mol Cell Biol Lipids 2020 Jan doi. 10.1016/j.bbalip.2019.04.009
Sarita Hebbar, Elisabeth Knust, Guillaume Thibault✉, Rachel Kraut✉. Editorial: Connections to Membrane Trafficking Where You Least Expect Them: Diseases, Dynamics, Diet and Distance. Front Cell Dev Biol 2019 Dec 6. doi. 10.3389/fcell.2019.00327
Wilson W.B. Goh, Subhash Thalappilly, Guillaume Thibault✉. Moving beyond the current limits of data analysis in longevity and healthy lifespan studies. Drug Discov Today 2019 Dec. doi. 10.1016/j.drudis.2019.08.008
Kizito Njah, Sayan Chakraborty, Beiying Qiu, Surender Arumugam, Anandhkumar Raju, Ajaybabu V. Pobbati, Manikandan Lakshmanan, Vinay Tergaonkar, Guillaume Thibault, Xiaomeng Wang, Wanjin Hong. A Role of Agrin in Maintaining the Stability of Vascular Endothelial Growth Factor Receptor-2 during Tumor Angiogenesis. Cell Rep 2019 Jul 23. doi. 10.1016/j.celrep.2019.06.036
Peter Shyu Jr, Benjamin S.H. Ng, Nurulain Ho, Ruijie Chaw, Yi Ling Seah, Charlie Marvalim, Guillaume Thibault✉. Membrane phospholipid alteration causes chronic ER stress through early degradation of homeostatic ER-resident proteins. Sci Rep 2019 Jun 14. doi. 10.1038/s41598-019-45020-6
Caroline Beaudoin-Chabot, Lei Wang, Alexey V. Smarun, Dragoslav Vidovic, Mikhail S. Shchepinov, Guillaume Thibault. Deuterated polyunsaturated fatty acids reduce oxidative stress and extend the lifespan of C. elegans. Front Physiol 2019 May 28. doi. 10.3389/fphys.2019.00641
Jhee Hong Koh, Lei Wang, Caroline Beaudoin-Chabot, Guillaume Thibault. Lipid bilayer stress-activated IRE-1 modulates autophagy during endoplasmic reticulum stress. J Cell Sci 2018 Nov 21. doi. 10.1242/jcs.217992
Peter Shyu Jr, Xing Fah Wong, Karen Crasta, Guillaume Thibault. Dropping in on lipid droplets: insights into cellular stress and cancer. Biosci Rep 2018 Sep 19, 38(5). doi.10.1042/BSR20180764
Nurulain Ho, Chengchao Xu, Guillaume Thibault✉. From the unfolded protein response to metabolic diseases - lipids under the spotlight. J Cell Sci 2018 Feb 8;131(3). doi. 10.1242/jcs.199307
Chengchao Xu, Songyu Wang, Guillaume Thibault, Davis T. Ng. Futile Protein Folding Cycles in the ER Are Terminated by the Unfolded Protein O-Mannosylation Pathway. Science 340, 978-981. doi. 10.1126/science.1234055
Guillaume Thibault , Guanghou Shui, Woong Kim, Graeme C. McAlister, Nurzian Ismail, Steven P. Gygi, Markus R. Wenk, Davis T. Ng. The membrane stress response buffers lethal effects of lipid disequilibrium by reprogramming the protein homeostasis network. Mol Cell 48, 16-27. doi. 10.1016/j.molcel.2012.08.016