Academic Profile

Academic Qualifications:
1. Bachelor of Science (Honours), Nanyang Technological University (NTU), Singapore 2002 – 2006
2. Doctor of Philosophy, NTU, Singapore 2006 - 2010

Employment History:
1. Associate Professor, LKCMedicine, NTU, Singapore 09/2019 - Present
2. Nanyang Assistant Professor, LKCMedicine, NTU, Singapore 09/2013 - 08/2019
3. Postdoctoral Fellow, HHMI/Yale University, USA 05/2010 - 09/2013
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Assoc Prof Luo Dahai
Associate Professor, Infection and Immunity, Lee Kong Chian School of Medicine
Associate Professor, Lee Kong Chian School of Medicine
Provost’s Chair in Medicine, Lee Kong Chian School of Medicine (LKCMedicine)

My primary research interest is to understand the molecular events involved in the battle between host and pathogens, in particular between RNA viruses and humankind. I developed this interest after I started my graduate work and I further cultivated it during my postdoctoral training. Using various methods ranging from biochemistry, biophysics, structural biology, and cell biology, I successfully answered interesting and demanding questions in the fields of viral replication and host defense systems. I would like to further my research career to better understand the conflict between host and pathogens and improve the well-being of humankind. My lab’s research focuses on the following two interrelated directions: 1) RNA virus transcription, replication, and the generation of pathogenic RNA species; 2) Host defense mechanisms involved in pathogenic RNA sensing and processing. We would like to exercise molecular engineering targeting RNA and RNA-protein complexes to develop new methods and tools for research and therapies.
 
  • Development of immune-modulatory RNAs to regulate RIG-Imediated antiviral immune response for therapy andvaccination

  • Fighting for Better Survival: Viral RNA Biogenesis versus Host Defense

  • Fluorescence-enhanced microarray for high-throughput detection of SARS-CoV-2 antigens and neutralizing antibodies

  • Provost's Chair in Medicine (Luo Dahai)

  • Structure Determination of NLRP6: Towards defining itsunique role in innate immunity, microbiota, and homeostasis of the gut

  • Studying Zika Virus Pathogenesis and the Development ofTherapeutics, in vitro Cell Culture Model and Mouse Modelthat Display Various Diseases Phenotypes

  • The Spike protein as a crucial tool to designtof vaccines, ELISA- based diagnostics and therapeutics