Academic Profile : Faculty
Assoc Prof Luo Dahai
Associate Professor, Infection and Immunity, Lee Kong Chian School of Medicine
Provost’s Chair in Medicine
Associate Professor, Lee Kong Chian School of Medicine
Email
External Links
Journal Articles
(Not applicable to NIE
staff as info will be
pulled from PRDS)
(Not applicable to NIE
staff as info will be
pulled from PRDS)
Phoo W.W., El Sahili A., Zhang Z., Chen M.W., Liew C.W., Lescar J., Vasudevan S.G., Luo D. (2020). Crystal structures of full length DENV4 NS2B-NS3 reveal the dynamic interaction between NS2B and NS3. Antiviral Res, 182:104900. doi: https://doi.org/10.1101/2020.01.27.907089
Yong, H.Y., Zheng, J., Ho, V.C.Y., Nguyen, M.T., Fink, K., Griffin, P.R., Luo, D. (2019). Structure-guided design of immunomodulatory RNAs specifically targeting the cytoplasmic viral RNA sensor RIG-I. FEBS Letters. 593(21):3003-3014. doi: 10.1002/1873-3468.13564
Law, Y.S., Utt, A., Tan, Y.B., Zheng, J., Wang, S., Chen, M.W., Griffin, P.R., Merits, A., Luo, D. (2019). Structural insights into RNA recognition by the Chikungunya virus nsP2 helicase. Proceedings of the National Academy of Sciences of the United States of America. 116(19):9558-9567. doi: 10.1073/pnas.1900656116
Yong, H.Y., Luo, D. (2018). RIG-I-Like Receptors as Novel Targets for Pan-Antivirals and Vaccine Adjuvants Against Emerging and Re-Emerging Viral Infections. Frontiers in Immunology. 9:1379. doi: 10.3389/fimmu.2018.01379.
Chen, M.W., Tan, Y.B., Zheng, J., Zhao, Y., Lim, B.T., Cornvik, T., Lescar, J., Ng, L., Luo, D. (2017). Chikungunya virus nsP4 RNA-dependent RNA polymerase core domain displays conditional, detergent-sensitive primer extension and terminal adenylyltransferase activities. Antiviral Research. 143:38-47. doi: 10.1016/j.antiviral.2017.04.001.
Zhang Z., Li Y., Loh Y.R., Phoo W.W., Hung W., Kang C., Luo D. (2016). Crystal structure of unlinked NS2B-NS3 protease from Zika virus. Science. Dec, b23;354(6319):1597-1600. doi: 10.1126/science.aai9309.
Phoo, W.W., Li, Y., Zhang, Z., Lee, M.Y., Loh, Y.R., Tan, Y.B., Ng, E.Y., Lescar, J., Kang, C., Luo, D. (2016). Structure of the NS2B-NS3 Protease from Zika Virus Caught after Self-Cleavage. Nature Communications. 7:13410. doi: 10.1038/ncomms13410
Zhao, Y., Soh, T.S., Lim, S.P., Chung, K.Y., Swaminathan, K., Vasudevan, S.G., Shi, P.Y., Lescar, J., Luo, D. (2015) Molecular basis for specific viral RNA recognition and 2'-O ribose methylation by the dengue virus NS5 protein. Proceedings of the National Academy of Sciences of the United States of America. 112(48):14834-9. doi: 10.1073/pnas.1514978112
Zhao, Y., Soh, S., Zheng, J., Phoo, W.W., Swaminathan, K., Cornvik, T.C., Lim, S.P., Shi, P.-Y., Lescar, J., Vasudevan, S.G., Luo, D. (2015). A Crystal Structure of the Dengue Virus Ns5 Protein Reveals a Novel Inter-Domain Interface Essential for Protein Flexibility and Virus Replication. PLoS Pathogens. 11(3):e1004682. https://doi.org/10.1371/journal.ppat.1004682
Zheng, J., Yong, H.Y., Panutdaporn, N., Liu, C., Tang, K., Luo, D. (2015). High-resolution HDX-MS reveals distinct mechanisms of RNA recognition and activation by RIG-I and MDA5. Nucleic Acids Research. 43(2):1216-30. doi: 10.1093/nar/gku1329
* Complete list of publications: Google Scholar
Yong, H.Y., Zheng, J., Ho, V.C.Y., Nguyen, M.T., Fink, K., Griffin, P.R., Luo, D. (2019). Structure-guided design of immunomodulatory RNAs specifically targeting the cytoplasmic viral RNA sensor RIG-I. FEBS Letters. 593(21):3003-3014. doi: 10.1002/1873-3468.13564
Law, Y.S., Utt, A., Tan, Y.B., Zheng, J., Wang, S., Chen, M.W., Griffin, P.R., Merits, A., Luo, D. (2019). Structural insights into RNA recognition by the Chikungunya virus nsP2 helicase. Proceedings of the National Academy of Sciences of the United States of America. 116(19):9558-9567. doi: 10.1073/pnas.1900656116
Yong, H.Y., Luo, D. (2018). RIG-I-Like Receptors as Novel Targets for Pan-Antivirals and Vaccine Adjuvants Against Emerging and Re-Emerging Viral Infections. Frontiers in Immunology. 9:1379. doi: 10.3389/fimmu.2018.01379.
Chen, M.W., Tan, Y.B., Zheng, J., Zhao, Y., Lim, B.T., Cornvik, T., Lescar, J., Ng, L., Luo, D. (2017). Chikungunya virus nsP4 RNA-dependent RNA polymerase core domain displays conditional, detergent-sensitive primer extension and terminal adenylyltransferase activities. Antiviral Research. 143:38-47. doi: 10.1016/j.antiviral.2017.04.001.
Zhang Z., Li Y., Loh Y.R., Phoo W.W., Hung W., Kang C., Luo D. (2016). Crystal structure of unlinked NS2B-NS3 protease from Zika virus. Science. Dec, b23;354(6319):1597-1600. doi: 10.1126/science.aai9309.
Phoo, W.W., Li, Y., Zhang, Z., Lee, M.Y., Loh, Y.R., Tan, Y.B., Ng, E.Y., Lescar, J., Kang, C., Luo, D. (2016). Structure of the NS2B-NS3 Protease from Zika Virus Caught after Self-Cleavage. Nature Communications. 7:13410. doi: 10.1038/ncomms13410
Zhao, Y., Soh, T.S., Lim, S.P., Chung, K.Y., Swaminathan, K., Vasudevan, S.G., Shi, P.Y., Lescar, J., Luo, D. (2015) Molecular basis for specific viral RNA recognition and 2'-O ribose methylation by the dengue virus NS5 protein. Proceedings of the National Academy of Sciences of the United States of America. 112(48):14834-9. doi: 10.1073/pnas.1514978112
Zhao, Y., Soh, S., Zheng, J., Phoo, W.W., Swaminathan, K., Cornvik, T.C., Lim, S.P., Shi, P.-Y., Lescar, J., Vasudevan, S.G., Luo, D. (2015). A Crystal Structure of the Dengue Virus Ns5 Protein Reveals a Novel Inter-Domain Interface Essential for Protein Flexibility and Virus Replication. PLoS Pathogens. 11(3):e1004682. https://doi.org/10.1371/journal.ppat.1004682
Zheng, J., Yong, H.Y., Panutdaporn, N., Liu, C., Tang, K., Luo, D. (2015). High-resolution HDX-MS reveals distinct mechanisms of RNA recognition and activation by RIG-I and MDA5. Nucleic Acids Research. 43(2):1216-30. doi: 10.1093/nar/gku1329
* Complete list of publications: Google Scholar