Academic Profile

SZE Siu-kwan Newman received multidisciplinary research trainings in chemical physics, protein chemistry, protein separation and characterization, and proteomics from University of Hong Kong, University of Toronto, University of Waterloo, and Cornell University under prominent research mentors (Nobel Laureate Professor John Polanyi - Chemical Physics, Professor Janus Pawlizyn - Protein Science, and Professor Fred McLafferty - Mass Spectrometry). After the intensive trainings, he engaged in the R&D of emerging proteomics technology in the Genome Institute of Singapore. After he joined NTU in June 2006, he has embarked on the establishment of a state-of-the-art proteomics facility in School of Biological Sciences and the application of advanced proteomic technologies to decipher human diseases through a rational search for novel disease targets and medicines.

Academic Qualifications/Professional Preparation:
1987-1990 B.Sc. (Chemistry, First Class Honors), University of Hong Kong
1990-1995 Ph.D. (Chemical Physics), University of Hong Kong
1995-1998 Postdoctoral Fellow (Chemical Physics), University of Toronto, Canada
1998-2001 Postdoctoral Fellow (Analytical Chemistry), University of Waterloo, Canada
2001-2002 Visiting Scientist (Proteomics for Life Sciences), Cornell University, USA
sksze_1_2.JPG picture
Assoc Prof Sze Siu Kwan
Associate Professor, School of Biological Sciences

Our research is devoted to develop and apply advanced proteomic technologies to decipher human diseases through a rational search for novel disease targets and medicines. As proteomics is still in the infancy stage, technology development is the key to advance the field to address more sophisticated biomedical questions. During the past few years, we have successfully developed a few novel proteomic techniques and applied to study proteins that are important to transcriptional and translational regulatory networks, DNA repair, and apoptotic pathway. More importantly, we have established a biological and biomarker discovery pipeline to study clinically important proteome systems relevant to host-pathogen response, cancer, and cardiovascular diseases
 
  • A Comprehensive Survey Of The Interactome Inside The Cytoplasm Of Red Blood Cell Infected By Plasmodium Parasite

  • Characterising The Anti-Aging Role Of The UPR From High Glucose Diet

  • Defining How Brain Tissue-Derived Exosomes Promote Experimental And Human Dementia

  • Defining the Enterococcus faecalis regulatory landscape

  • Engineering Scaffold-Mediated Neural Cell Therapy for Spinal Cord Injury Treatment

  • Engineering Scaffold-Mediated Neural Cell Therapy for Spinal Cord Injury Treatment (Astar)

  • Engineering Scaffold-Mediated Neural Cell Therapy for Spinal Cord Injury Treatment (NTU)

  • Functional implication of cytoplasmic EZH2 in cancer stem cells

  • IMC Compartmentalization and its role in maturation and transmission of P. falciparum gametocytes

  • Improving resolution of batch effects in proteomics data using data-smart strategies: 3 aspects

  • Investigating nuclear dynamics of excitatory neurons andastrocytes during epileptogenesis

  • Mechanosenstive Responses Of Tumor Cells Under Compression

  • Molecular basis of plant cellulose biosynthesis and its regulation

  • Molecular Phenotyping of Young Adult-Onset Diabetes Mellitus Patients in Singapore - A Systems Medicine Approach

  • Signatures of human plaque protein levels predictive for human cardiovascular events

  • Study Early Asymptomatic Molecular Pathology Of Neurodegeneration In Dementia: Proteomic Identification Of Priority Drug Tragets

  • The mechanistic study of the effect of amino acids on the endocytic trafficking

  • The Regulation Of Focal Adhesions In Embryonic Stem Cells
 
  • P. Hao, T. Guo and S. K. Sze. (2011). Simultaneous analysis of proteome, phospho- and glycoproteome of rat kidney tissue with electrostatic repulsion hydrophilic interaction chromatography. PLoS ONE, 6(2), e16884.

  • T. Guo, Y. Zhu, C. S. Gan, S. S. Lee, J. Zhu, H. Wang, X. Li, J. Christensen, S. Huang, O. L. Kon and S. K. Sze. (2010). Quantitative Proteomics Discloses MET Expression in Mitochondria as a Direct Target of MET Kinase Inhibitor in Cancer Cells. Molecular and Cellular Proteomics, 9(12), 2629-41.

  • W. Peeters, D. P. de Kleijn, A. Vink, S. van de Weg, A. H. Schoneveld, S. K. Sze, P. J. van der Spek, J. P. de Vries, F. L. Moll and G. Pasterkamp. (2010). Adipocyte fatty acid binding protein in atherosclerotic plaques is associated with local vulnerability and is predictive for the occurrence of adverse cardiovascular events. European Heart Journal, .

  • T. Guo, S. S. Lee, W. H. Ng, Y. Zhu, C. S. Gan, J. Zhu, H. Wang, S. Huang, S. K. Sze and O. L. Kon. (2010). Global molecular dysfunctions in gastric cancer revealed by an integrated analysis of the phosphoproteome and transcriptome. Cellular and Molecular Life Sciences, .

  • Adav SS, Li AA, Manavalan A, Punt P, Sze SK. (2010). Quantitative iTRAQ secretome analysis of Aspergillus niger reveals novel hydrolytic enzymes. Journal of Proteome Research, 9(8), 3932-40.