Academic Profile : Faculty

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Prof Xing Bengang
Professor, School of Physical & Mathematical Sciences - Division of Chemistry & Biological Chemistry
Professor, School of Chemical and Biomedical Engineering
External Links
 
Dr. Xing received his Bachelor Degree in Chemistry from Xinjiang Normal University 1994, and Ph.D. Degree from Nanjing University in 2000, respectively. After that, he moved to the Department of Chemistry, at the Hong Kong University of Science and Technology (HKUST) as a research staff. In 2003, Dr. Xing went to the Crump Institute of Molecular Imaging at the University of California, Los Angeles (UCLA) and the Molecular Imaging Program at Stanford University (MIPS) to pursue his post-doc research training. In Dec. of 2005, he started his independent research career at the Division of Chemistry & Biological Chemistry (CBC), School of Physical & Mathematical Sciences (SPMS), Nanyang Technological University (NTU), where he was promoted to a tenured Associate Professor in 2011. From 2011 to 2018, Dr. Xing was holding the appointments as Deputy Head in CBC and Assistant Chair in SPMS for academic education. In 2019, Dr. Xing was officially installed as Full Professor in NTU.

Awards and Honor Representatives:

2007 The Asian Core Program (ACP), Lectureship Award, South Korea
2011 Lectureship Award for Chemistry Research Promotion Center National Science Council. Taiwan.
2013 Collaborative Research Award, College of Sciences, NTU
2015 COS idea competition Award, College of Science, NTU
2016 The Reaxys phD prize, as supervisor
2018 Young Innovator Award in Nano-biotechnology, featured by Nano Research
Dr. XING's research interests are highly interdisciplinary at the interfaces of Biomedical Fluorescent Imaging, Chemical Biology as well as Nano-medicine and Pharmaceutical Chemistry. Specific aims of ours are to integrate the knowledge of synthesis chemistry, chemical biology and optical imaging sensing techniques to develop the "smart" probes and contrast agents for real-time sensing of diseases active molecules or precisely monitoring of biomedical pathway in living systems. We are also interested in development of unique functional nanomaterials for drug/gene delivery, biocatalysis and multi-modality imaging of biomarkers, unique biomolecules and reactive radical species (e.g. ROS, RNS etc) for potential clinical diagnosis.

1. Biomedical Fluorescent Imaging / Chemical Biology:

a) Development of new fluorescent probes and specific labeling strategies for point-of-care imaging of drug resistant bacterial pathogens.
b) Unique strategies for real-time monitoring of bioactive molecules in tumor cells.
c) Site-specific localization of unique probe contrast agents for precise regulation of cell functions.

2. Nano-theranostics:

a) Unique and smart NIR light mediated functional platforms for localized tumor theranostics.
b) Multi-modality sensing and imaging of biomarkers, unique biofunctional molecules as well as reactive radical species under living settings.
c) NIR light mediated optogentics for precise regulation of disease cell functions.

3. Biomaterials:

Design, synthesis and characterization of new transporters and/or the peptides based hydrogels for biomedical applications.
 
  • Development of Small-Molecule Probes for Simultaneous Profiling of Multiple Free-Radical Evolutions in Bacterial Pathogenesis
  • Engineering of Gut Bacteria Exosome Vesicles for Diet-guided Gastrointestinal Theranostics
  • Increasing antibiotic activity by rapid bioorthogonal conjugation of drug to resistant bacteria using an upconverted light-activated photocatalyst
  • Intelligent Photonic Tunable Nanophosphors: Recomposition and Storage of Sunlight for Enhanced Photosynthesis
US 2017/0029373 A1: Allenamides As An Orthogonal Handle For Selective Modification Of Cysteine In Peptides And Proteins (2019)
Abstract: There is provided a compound of formula I, having the structure: wherein R1 to R5 have the meanings given in the description.

US 2014/0322739 A1: Methods and Compounds for Screening Beta-Lactamase Activity (2016)
Abstract: The present invention relates to compounds for and a method of detecting beta-lactamase activity in a sample. The sample is contacted with a nanoparticulate tag. The nanoparticulate tag comprises a metal or a combination of metals, or it comprises a nanotube of a metal, boron nitride and/or carbon. The respective metal is capable of forming one of a covalent bond, a coordinative bond and a non-covalent interaction with a thio or a seleno group. The sample is contacted with a compound of one of general formulas (I)-(III) and (VII)-(IX). At least one beta-lactam moiety of the compound is cleaved by the beta-lactamase activity in the sample. As a result a cleavage moiety Z-A-Z, Z-A-Z—R15, Z-A-Z—R16, Z-A-Z—R17, Z-A-Z—R18 or Z-G-N(R8)R9 is released that is immobilized on the surface of the nanoparticulate tag by a covalent bond via a Z atom. The presence of beta-lactamase activity is determined based on the presence of the cleavage moiety immobilized onto the surface of the nanoparticulate tag.

US-2009-0275065-A1: Site-Specific Induction Of Bimolecular Quadruplex-Duplex Hybrids And Methods Of Using The Same (2014)
Abstract: The present invention relates to compounds for and a method of detecting beta-lactamase activity in a sample. The sample is contacted with a nanoparticulate tag. The nanoparticulate tag comprises a metal or a combination of metals, or it comprises a nanotube of a metal, boron nitride and/or carbon.

US 2012-0288884 A1: Quinazolinone Based Fluorogenic Probes (2014)
Abstract: The present invention relates to a compound of the general formula (I) useful in the determining the presence, amount or activity of an enzyme in living cells, a method of preparing said compounds and a kit thereof.