Academic Profile

Prof Surajit Bhattacharyya is an Associate Professor (Tenured) at the School of Biological Sciences (SBS). He received his Ph.D. degree from the Indian Institute of Science, Bangalore, India. Before joining NTU-SBS, Prof Bhattacharyya was a Staff Scientist at the National Research Council of Canada, Montreal. Prof Bhattacharyya’s laboratory has been involved in cutting edge researches of diverse nature, investigating 1. Molecular mechanisms of cell adhesion proteins, integrins and development of therapeutics against cancer, inflammation and blood related diseases. 2. Host defense antimicrobial peptides and proteins with aim to design new antimicrobials and antiendotoxic molecules. 3. De-novo designed functional synthetic proteins. He has published over 80 journal papers either as principal or senior author. Prof Bhattacharyya has been often invited as a referee and reviewer for a number of premier journals, including Nature Communications, Scientific Reports, Biochemistry, Langumur, Biopolymers, BBA, JACS and other ACS journals. Prof Bhattacharyya serves as an Academic Editor of the journals PLOS-ONE and Scientific Reports. Prof Bhattacharyya is a Fellow of the Royal Society of Chemistry (FRSC) and Overseas Fellow of the Royal Society of Medicine (UK). Prof Bhattacharyya has developed several courses for undergraduate students and actively engaged in teaching. In addition, Prof Bhattacharyya severs various committees both at the university and school level.
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Assoc Prof Surajit Bhattacharyya
Associate Professor, School of Biological Sciences

Molecular Mechanism of cell adhesion: Interactions of Integrin Tails with Effector Proteins
Designed Peptide Antagonists against Endotoxin: A structure-based approach to develop antisepsis and antimicrobial drugs.
De Novo designed functional mini-proteins
Structure and activity of antimicrobial peptides
  • Enhanced Thermal Energy Storage Using Topologically Optimised Structures And Novel Phase Change

  • Structural analyses of interactions between kindlin 3 with its binding partners RACK1 and IGF2BP1
  • Anirban Bhunia, Harini Mohanram, Prerna N. Domadia, Jaume Torres, and Surajit Bhattacharjya. (2009). Designed beta-boomerang antiendotoxic and antimicrobial peptides: structures and activities in lipopolysaccharide. Journal of Biological Chemistry 284, 21991-22004. [Paper of the week].

  • Anirban Bhunia, Xiao-Yan Tang, Harini Mohanram, Suet-Mien Tan and Surajit Bhattacharjya*. (2009). NMR solution conformations and interactions of integrin aLb2 cytoplasmic tails. Journal of Biological Chemistry, 284, 3873-3884

  • Prerna N Domadia, Anirban Bhunia, Ayyalusamy Ramamoorthy and Surajit Bhattacharjya. (2010). Structure, interactions and antibacterial activities of MSI-594 derived mutant peptide MSI-594F5A in lipopolysaccharide micelles: role of the helical hairpin conformation in outer-membrane permeabilization. Journal of the American Chemical Society, 132, 18417-18428.

  • Mukesh Mahajan and Surajit Bhattacharjya. (2013). beta-hairpin peptides: heme binding, catalysis and structure in detergent micelles. Angew. Chem. Int. Ed, 52, 6430-6434.

  • Harini Mohanram and Surajit Bhattacharjya. (2014). Resurrecting inactive antimicrobial peptides from lipopolysaccharide (LPS) trap. Antimicrobial Agents & Chemotherapy, 58,1987-1996

  • Deepak Chatterjee, Lewis Lu Zhiping, Suet-Mien Tan and Surajit Bhattacharjya. (2016). Interaction analyses of the integrin b2 cytoplasmic tail with the F3 FERM domain of talin and 14-3-3z reveal a ternary complex with phosphorylated tail. J. Mol. Biology 428(20):4129-4142.

  • Areetha D’Souza, Xiangyang Wu, Edwin Kok Lee Yeow, Surajit Bhattacharjya. (2017). Designed heme-cage beta-sheet mini-proteins. Angew. Chem. Int. Ed. 56, 5904-5908.

  • Sheetal Sinha, Liangzhen Zheng, Yuguang Mu, Wun Jern Ng & Surajit Bhattacharjya Structure and interactions of a host defense antimicrobial peptide thanatin in lipopolysaccharide micelle reveal mechanism of bacterial cell agglutination. (2017). Scientific Reports 7(1):17795. doi: 10.1038/s41598-017-18102-6

  • Deepak Chatterjee, Areetha D’Souza, Yaming Zhang, Wu Bin, Suet-Mien Tan & Surajit Bhattacharjya. (2018). Interaction analyses of scaffold protein 14-3-3z, adaptor protein Dok1 and phosphorylated beta cytosolic tails of integrins reveal a binary switch mechanism of recognition. J. Mol. Biol. 430(21):4419-4430.

  • Shengtao Lu, Wuguo Bi, Quanchao Du, Sheetal Sinha, Xiangyang Wu, Arnold Subrata, Surajit Bhattacharjya, Bengang Xing & Edwin K. L. Yeow. (2018). Lipopolysaccharide-affinity copolymer senses the rapid motility of swarmer bacteria to trigger antimicrobial drug release. Nature Communications 9(1):4277.