Academic Profile : Faculty

Ali Miserez.jpg picture
Prof Ali Miserez
Professor, School of Materials Science & Engineering
President's Chair in Materials Science and Engineering
Professor, School of Biological Sciences
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Ali Miserez is a Faculty member in the School of Materials Science and Engineering and the School of Biological Sciences at Nanyang Technological University (NTU) in Singapore. He graduated from the Ecole Polytechnique Fédérale de Lausanne (EPFL, Switzerland) with a PhD in Materials Science and Engineering (2003) and a specialization in advanced metal/ceramic composites and mechanics of materials. In 2004, he received a Swiss National Science Foundation post-doc fellowship and moved to the University of California, Santa Barbara (UCSB), where he was affiliated with the Materials Department and the Marine Science Institute. At UCSB, he expanded his research interest towards biological materials and biomimetics working in the group of Prof. Herb Waite. In 2009, he moved to NTU as an Assistant Professor, and in 2011 he was awarded the Singapore National Research Foundation (NRF) Fellowship, a $3 Million individual research grant for early career scientists.

Dr. Miserez’s research is centered on revealing the molecular, physico-chemical, and structural principles from unique biological materials, and on translating these designs into novel biomimetic synthesis strategies. His research group is strongly cross-disciplinary, with molecular biologists, chemists, bio-physicists, and materials scientists combining their expertise towards bioinspired engineering from various angles, including protein biochemistry, extra-cellular tissue transcriptomic, polymer chemistry, biomimetic peptide design, biophysics, and nanomechanics. In recent years, his work has appeared in both general (Science, Nature Materials, Nature Biotechnology, Nature Chemical Biology, Advanced Materials) and specialized journals (Biomacromolecules, ACS Nano, JBC, Polymer Chemistry, etc, ). He has delivered numerous invited talks, including at various Gordon Research Conferences in the field of bioinspired materials and biomineralization.
Structural properties of biological materials from the macro-scale to the nano-scale
Multi-scale structural and mechanical properties of biological materials, including biominerals.
Elastomeric and structural properties of bioelastomers
Protein chemistry of sclerotized hard-tissues from marine organisms, such as Cephalopod
Single-molecular force spectroscopy of structural and elastic proteins
Underwater adhesion mechanisms of adhesive proteins
RNA-sequencing and proteomics of extra-cellular biological materials
Advanced Metal/Ceramic composites
Experimental Fracture Mechanics
  • Advanced Microbial Detection: Using Peptide Coacervates to Remove Interferents in Leafy Vegetable Test Samples
  • Coacervates/mRNA for Targeted Cancer Therapy
  • Extracellular vesicles CAR T-cell against MRSA infection
  • Phase Separation Regulated Life, In and Outside of Cells
  • Phase-Separating Peptides as a General Platform for Intracellular Delivery of Antibody Therapeutics
  • Phase-Separating Peptides as a General Platform for Intracellular Delivery of Antibody Therapeutics - WP1 : Engineered Phase-Separation Peptides for Antibody Recruitment
  • Phase-Separating Peptides as a General Platform for Intracellular Delivery of Antibody Therapeutics - WP3 : Assessment of Antibodies and Antibodies Mimetics Activity Inside Cells [ A*star: Farid Ghadessy & Chris Brown]
  • President's Chair in Materials Science and Engineering
  • Reflectin-incorporated hydrogels for controllable chemical change materials
  • Targeted in vivo delivery of anti-cancer mRNA therapeutics using peptide coacervates
US 2015/0274789 A1: Compounds And Methods For The Production Of Suckerin And Uses Thereof (2021)
Abstract: Sucker ring tooth (SRT) proteins called Suckerins were identified from the sucker tissue of three distantly related Decapodiformes species. These proteins assemble into silk-like beta-sheet reinforced materials. The use of suckerin proteins to produce fibres, films and tissue scaffolds is also described.