Dr. Meng How Tan received his B.S. degree in mechanical engineering and B.A. degree in economics from University of California - Berkeley, his M.S. degree in aeronautics from California Institute of Technology, his M.S. degree in biomedical engineering from NTU, and his Ph.D. in developmental biology from Stanford University. He then performed postdoctoral research at Stanford University with Jin Billy Li, Mylene Yao, and Wing Hung Wong. Subsequently, he joined NTU as an Assistant Professor in 2014 and was promoted to an Associate Professor with tenure in 2021. He is also currently the Assistant Chair (Students) in the School of Chemical and Biomedical Engineering. His lab works actively in the field of nucleic acid editing. To date, he has published multiple papers in top academic journals, such as Nature, Nature Biotechnology, Nature Chemical Biology, and Nature Communications. He received the Outstanding Young Principal Investigator Award from The American Institute of Chemical Engineers – Singapore Local Section (AIChE-SLS) in 2019 and was named an EMBO Global Investigator in 2020.
Meng How’s overall research goal is to advance the field of nucleic acid editing. His lab seeks to (1) develop new genome and transcriptome engineering tools, including CRISPR-based technologies, for synthetic biology applications, and (2) gain fundamental insights into the ADAR family of enzymes, which are essential proteins involved in RNA editing.
- A robust and sensitive CRISPR-based diagnostic assay for COVID-19
- A Sustainable Bio-platform for High Quality Microbial Protein Production
- A Sustainable Bio-platform for High Quality Microbial Protein Production (SCBE-TMH_NEW)
- A Sustainable Bio-platform for High Quality Microbial Protein Production (SCBE-TMH)
- Cancer drug target discovery via new CRISPR screening modalities
- Digital Single Cell Printing (HP)
- Digital Single Cell Printing (IAF-ICP)
- Digital Single Cell Printing (NTU)
- EMBO Global Investigator Network (GIN)
- Investigating The Critical Role Of RNA Editing During Vertebrate Development
- Ooi K.H.*, Liu M.M.*, Tay J.W.D.*, Teo S.Y.*, Kaewsapsak P.*, Jin S., Lee C.K., Maurer-Stroh S., Yan B., Yan G., Gao Y.-G., and Tan M.H. (2021) An engineered CRISPR-Cas12a variant and DNA-RNA hybrid guides enable robust and rapid COVID-19 testing. Nature Communications 12(1):1739.
- Aw J.G.A.*, Lim S.W.*, Wang J.X.*, Lambert F.R.P., Tan W.T., Shen Y., Zhang Y., Kaewsapsak P., Li C., Ng S.B., Vardy L.A., Tan M.H., Nagarajan N.†, and Wan Y.† (2021) Determination of isoform-specific RNA structure with nanopore long reads. Nature Biotechnology 39(3): 336-346.
- Shanmugam R.*, Zhang F.*, Srinivasan H., Charles Richard J.L., Liu K.I., Zhang X., Woo C.W.A., Chua Z.H.M., Buschdorf J.P., Meaney M.J., and Tan M.H. (2018) SRSF9 selectively represses ADAR2-mediated editing of brain-specific sites in primates. Nucleic Acids Research 46(14): 7379-7395.
- Wang Y.*, Liu K.I.*, Sutrisnoh N.A.B., Srinivasan H., Zhang J., Li J., Zhang F., Charles R.J.L., Xing H., Shanmugam R., Foo J.N., Yeo H.T., Ooi K.H., Bleckwehl T., Par Y.Y.R., Lee S.M., Ismail N.N.B., Sanwari N.A.B., Lee S.T.V., Lew J., and Tan M.H. (2018) Systematic evaluation of CRISPR-Cas systems reveals design principles for genome editing in human cells. Genome Biology 19: 62.
- Tan M.H.*†, Li Q.*, Shanmugam R., Piskol R., Kohler J., Young A.N., Liu K.I., Zhang R., Ramaswami G., Ariyoshi K., Gupte A., Keegan L.P., George C.X., Ramu A., Huang N., Pollina E.A., Leeman D., Rustighi A., Goh Y.P.S., The GTEx Consortium, Chawla A., Del Sal G., Peltz G., Brunet A., Conrad D.F., Samuel C.E., O’Connell M.A., Walkley C.R., Nishikura K., and Li J.B.† (2017) Dynamic landscape and regulation of RNA editing in mammals. Nature 550: 249-254.
- Liu K.I., Ramli M.N.B., Woo C.W.A., Wang Y., Zhao T., Zhang X., Yim G.R.D., Chong B.Y., Gowher A., Chua M.Z.H, Jung J., Lee J.H.J., and Tan M.H. (2016) A chemical-inducible CRISPR-Cas9 system for rapid control of genome editing. Nature Chemical Biology 12(11): 980-987.