Academic Profile : No longer with NTU

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Assoc Prof Liu Quan
Associate Professor, School of Chemical and Biomedical Engineering
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Dr. Quan Liu received the PhD degree in Biomedical Engineering from the University of Wisconsin, Madison. He is currently an associate professor in the School of Chemical and Biomedical Engineering at Nanyang Technological University in Singapore. His research interest is focused on optical imaging and spectroscopy for medical diagnostics. Dr. Liu has published more than sixty journal papers and held sixteen US patents/applications in the field of biomedical optics. He has also secured a total mount of external funding more than four million USD to support his group. Dr. Liu has served as a reviewer for several top journals, such as Optics Letters, Optics Express and Nature Communication, and multiple international funding agencies as well as a subcommittee member and session chair for multiple international conferences such as European Conferences in Biomedical Optics (ECBO) and Photonics West. Dr. Liu is a senior SPIE member.

Dr. Quan Liu and his group's research in biomedical optics, i.e. biophotonics, focus on developing "optical biopsy" methods based on optical imaging and spectroscopy including diffuse reflectance, fluorescence and Raman techniques. These methods can non-invasively characterize the pathological status of tissues for medical diagnostics to reduce or even remove the need of performing physical biopsies. This group aims to address fundamental challenges that prevent these techniques from being clinically applicable by developing novel optical methods and/or incorporating other complementary techniques such as elastography, nanotechnology enabled plasmonics and ultrasound imaging, in a purpose to enhance the capability of optical biopsy methods in the accuracy, the signal to noise ratio, the spatial resolution and multiplexing capability. We are also interested in looking at the therapeutic effect of laser enabled therapy in cancer and the identification of rare tumor cells with optical spectroscopy. In parallel to technical development, his group also performs translational research to transfer these powerful optical techniques from benchtop to beside.

Dr. Liu's group is constantly looking for motivated candidates of postdoctoral researchers, research assistants and PhD students.

For more information, please visit his group's homepage at
• Biophotonics
• Biomedical optical spectroscopy and imaging
• Non-invasive medical diagnostics
• Biomedical instrumentation
  • Engineering Scaffold-Mediated Neural Cell Therapy for Spinal Cord Injury Treatment
  • Engineering Scaffold-Mediated Neural Cell Therapy for Spinal Cord Injury Treatment (SMART CAMP)
  • Wound Care Innovation for the Tropics: Second Harmonic Imaging to Determine the State of Healing of Chronic Wounds under the Tools, Devices and Therapies
US 2016/0331230 A1: Device For Determining A Condition Of An Organ And Method Of Operating The Same (2018)
Abstract: In various embodiments, device for determining a condition of an organ of either a human or an animal may be provided. The device may include a first optical source and a second optical source. The device may also include a detector. The device may additionally include a lens system. The device may further include a switching mechanism configured to switch between an optical examination mode and a Raman mode. The lens system during the optical examination mode may be configured to direct a first light emitted from the first optical source. The lens system during the Raman mode may be configured to direct a second light emitted from the second optical source. The lens systems during the Raman mode may be further configured to direct a third light to the detector.

US 2015/0062573 A1: Optical Detection Device And Optical Detection Method (2018)
Abstract: According to embodiments of the present invention, an optical detection device is provided. The optical detection device includes an optics arrangement configured to generate an annular illumination pattern to illuminate a portion of a sample and further configured to receive a return light from the portion of the sample illuminated by the annular illumination pattern; and a detector arrangement configured to detect the return light. According to further embodiments of the present invention, an optical detection method is also provided.

US-2012-0257199-A1: Method Of Diagnosing Malaria Infection In A Patient By Surface Enhanced Resonance Raman Spectroscopy (2017)
Abstract: Present disclosure relates to a method of diagnosing malaria infection in a patient by Surface Enhanced Raman Spectroscopy (SERS). The method includes obtaining a sample from said patient, mixing the sample with a suspension of magnetic nanoparticles, wherein said magnetic nanoparticles adsorb hemozoin present in the sample onto their surface, obtaining the SERS spectra of the sample, and correlating the obtained SERS spectra to the presence or amount of hemozoin in the sample, wherein the presence of hemozoin is indicative of malaria infection.