Academic Profile : Faculty

Prof Phan Anh Tuân_1.jpg picture
Prof Phan Anh Tuan
Chair, School of Physical and Mathematical Sciences (SPMS)
Lee Soo Ying Professorship in Biological Physics
Professor, School of Physical & Mathematical Sciences - Division of Physics & Applied Physics
Professor, School of Biological Sciences (Courtesy Appointment)
Professor, School of Chemistry, Chemical Engineering and Biotechnology (Courtesy Appointment)
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Journal Articles
(Not applicable to NIE
staff as info will be
pulled from PRDS)
Highly Cited:
Patel, D. J., Phan, A. T., & Kuryavyi, V. (2007). Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes : diverse higher order DNA and RNA targets for cancer therapeutics. Nucleic Acids Research, 35(22). doi: 10.1093/nar/gkm711

Luu, K. N., Phan, A. T., Kuryavyi, V., Lacroix, L., & Patel, D. J. (2006). Structure of the human telomere in K+ solution :  an intramolecular (3 + 1) G-quadruplex scaffold. Journal of the American Chemical Society, 128(30), 9963–9970. doi: 10.1021/ja062791w

Mergny, J.-L., Phan, A. T., & Lacroix, L. (1998). Following G-quartet formation by UV-spectroscopy. FEBS Letters, 435(1), 74-78. doi: 10.1016/S0014-5793(98)01043-6

Phan, A. T., Modi, Y. S., & Patel, D. J. (2004). Propeller-type parallel-stranded G-quadruplexes in the human c-myc promoter. Journal of the American Chemical Society, 126(28), 8710–8716. doi: 10.1021/ja048805k

Serganov, A., Yuan, Y.-R., Pikovskaya, O., Polonskaia, A., Malinina, L., Phan, A. T., ... Patel, D. J. (2004). Structural basis for discriminative regulation of gene expression by adenine- and guanine-sensing mRNAs. Chemistry & Biology, 11(12), 1729-1741. doi: 10.1016/j.chembiol.2004.11.018

Phan, A. T., Kuryavyi, V., Gaw, H. Y., & Patel, D. J. (2005). Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter. Nature Chemical Biology, 1, 167–173. doi: 10.1038/nchembio723

Phan, A. T., Kuryavyi, V., Luu, K. N., & Patel, D. J. (2007). Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K + solution. Nucleic Acids Research, 35(19), 6517–6525. doi: 10.1093/nar/gkm706

Phan, A. T. (2010). Human telomeric G-quadruplex : structures of DNA and RNA sequences. The FEBS Journal, 277(5), 1107-1117. doi: 10.1111/j.1742-4658.2009.07464.x

Phan, A. T., & Mergny, J.-L. (2002). Human telomeric DNA : G‐quadruplex, i‐motif and Watson–Crick double helix. Nucleic Acids Research, 30(21), 4618–4625. doi: 10.1093/nar/gkf597

Lim, K. W., Amrane, S., Bouaziz, S., Xu, W., Mu, Y., PateL, D. J., ... Phan, A. T. (2009). Structure of the human telomere in K+ solution : a stable basket-type G-quadruplex with only two G-tetrad layers. Journal of the American Chemical Society, 131(12), 4301–4309. doi: 10.1021/ja807503g

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Recent Publication:
Devi, G., Winnerdy, F. R., Ang, J. C. Y., Lim, K. W., & Phan, A. T. (2021). Four-layered intramolecular parallel G-quadruplex with non-nucleotide loops : an ultra-stable self-folded DNA nano-scaffold. ACS Nano, 16(1), 533-540.

Patil, K. M., Chin, D., Seah, H. L., Shi, Q., Lim, K. W., & Phan, A. T. (2021). G4-PROTAC : targeted degradation of a G-quadruplex binding protein. Chemical Communications, 57(95), 12816-12819.

Dao, N. T., Haselsberger, R., Khuc, M. T., Phan, A. T., Voityuk, A. A., & Michel-Beyerle, M. E. (2021). Photophysics of DFHBI bound to RNA aptamer Baby Spinach. Scientific Reports, 11(1), 1-9.

Seviour, T., Winnerdy, F. R., Wong, L. L., Shi, X., Mugunthan, S., Foo, Y. H., ... & Kjelleberg, S. (2021). The biofilm matrix scaffold of Pseudomonas aeruginosa contains G-quadruplex extracellular DNA structures. npj Biofilms and Microbiomes, 7(1), 1-12.

Chatain, J., Blond, A., Phan, A. T., Saintomé, C., & Alberti, P. (2021). GGGCTA repeats can fold into hairpins poorly unfolded by replication protein A : a possible origin of the length-dependent instability of GGGCTA variant repeats in human telomeres. Nucleic Acids Research, 49(13), 7588-7601.
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