Academic Profile : Faculty
Prof Phan Anh Tuan
Chair, School of Physical and Mathematical Sciences (SPMS)
Lee Soo Ying Professorship in Biological Physics
Professor, School of Physical & Mathematical Sciences - Division of Physics & Applied Physics
Professor, School of Biological Sciences (Courtesy Appointment)
Professor, School of Chemistry, Chemical Engineering and Biotechnology (Courtesy Appointment)
Email
Journal Articles
(Not applicable to NIE
staff as info will be
pulled from PRDS)
(Not applicable to NIE
staff as info will be
pulled from PRDS)
Highly Cited:
Patel, D. J., Phan, A. T., & Kuryavyi, V. (2007). Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes : diverse higher order DNA and RNA targets for cancer therapeutics. Nucleic Acids Research, 35(22). doi: 10.1093/nar/gkm711
Luu, K. N., Phan, A. T., Kuryavyi, V., Lacroix, L., & Patel, D. J. (2006). Structure of the human telomere in K+ solution : an intramolecular (3 + 1) G-quadruplex scaffold. Journal of the American Chemical Society, 128(30), 9963–9970. doi: 10.1021/ja062791w
Mergny, J.-L., Phan, A. T., & Lacroix, L. (1998). Following G-quartet formation by UV-spectroscopy. FEBS Letters, 435(1), 74-78. doi: 10.1016/S0014-5793(98)01043-6
Phan, A. T., Modi, Y. S., & Patel, D. J. (2004). Propeller-type parallel-stranded G-quadruplexes in the human c-myc promoter. Journal of the American Chemical Society, 126(28), 8710–8716. doi: 10.1021/ja048805k
Serganov, A., Yuan, Y.-R., Pikovskaya, O., Polonskaia, A., Malinina, L., Phan, A. T., ... Patel, D. J. (2004). Structural basis for discriminative regulation of gene expression by adenine- and guanine-sensing mRNAs. Chemistry & Biology, 11(12), 1729-1741. doi: 10.1016/j.chembiol.2004.11.018
Phan, A. T., Kuryavyi, V., Gaw, H. Y., & Patel, D. J. (2005). Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter. Nature Chemical Biology, 1, 167–173. doi: 10.1038/nchembio723
Phan, A. T., Kuryavyi, V., Luu, K. N., & Patel, D. J. (2007). Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K + solution. Nucleic Acids Research, 35(19), 6517–6525. doi: 10.1093/nar/gkm706
Phan, A. T. (2010). Human telomeric G-quadruplex : structures of DNA and RNA sequences. The FEBS Journal, 277(5), 1107-1117. doi: 10.1111/j.1742-4658.2009.07464.x
Phan, A. T., & Mergny, J.-L. (2002). Human telomeric DNA : G‐quadruplex, i‐motif and Watson–Crick double helix. Nucleic Acids Research, 30(21), 4618–4625. doi: 10.1093/nar/gkf597
Lim, K. W., Amrane, S., Bouaziz, S., Xu, W., Mu, Y., PateL, D. J., ... Phan, A. T. (2009). Structure of the human telomere in K+ solution : a stable basket-type G-quadruplex with only two G-tetrad layers. Journal of the American Chemical Society, 131(12), 4301–4309. doi: 10.1021/ja807503g
Click here for more publications.
Recent Publication:
Devi, G., Winnerdy, F. R., Ang, J. C. Y., Lim, K. W., & Phan, A. T. (2021). Four-layered intramolecular parallel G-quadruplex with non-nucleotide loops : an ultra-stable self-folded DNA nano-scaffold. ACS Nano, 16(1), 533-540.
Patil, K. M., Chin, D., Seah, H. L., Shi, Q., Lim, K. W., & Phan, A. T. (2021). G4-PROTAC : targeted degradation of a G-quadruplex binding protein. Chemical Communications, 57(95), 12816-12819.
Dao, N. T., Haselsberger, R., Khuc, M. T., Phan, A. T., Voityuk, A. A., & Michel-Beyerle, M. E. (2021). Photophysics of DFHBI bound to RNA aptamer Baby Spinach. Scientific Reports, 11(1), 1-9.
Seviour, T., Winnerdy, F. R., Wong, L. L., Shi, X., Mugunthan, S., Foo, Y. H., ... & Kjelleberg, S. (2021). The biofilm matrix scaffold of Pseudomonas aeruginosa contains G-quadruplex extracellular DNA structures. npj Biofilms and Microbiomes, 7(1), 1-12.
Chatain, J., Blond, A., Phan, A. T., Saintomé, C., & Alberti, P. (2021). GGGCTA repeats can fold into hairpins poorly unfolded by replication protein A : a possible origin of the length-dependent instability of GGGCTA variant repeats in human telomeres. Nucleic Acids Research, 49(13), 7588-7601.
Patel, D. J., Phan, A. T., & Kuryavyi, V. (2007). Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes : diverse higher order DNA and RNA targets for cancer therapeutics. Nucleic Acids Research, 35(22). doi: 10.1093/nar/gkm711
Luu, K. N., Phan, A. T., Kuryavyi, V., Lacroix, L., & Patel, D. J. (2006). Structure of the human telomere in K+ solution : an intramolecular (3 + 1) G-quadruplex scaffold. Journal of the American Chemical Society, 128(30), 9963–9970. doi: 10.1021/ja062791w
Mergny, J.-L., Phan, A. T., & Lacroix, L. (1998). Following G-quartet formation by UV-spectroscopy. FEBS Letters, 435(1), 74-78. doi: 10.1016/S0014-5793(98)01043-6
Phan, A. T., Modi, Y. S., & Patel, D. J. (2004). Propeller-type parallel-stranded G-quadruplexes in the human c-myc promoter. Journal of the American Chemical Society, 126(28), 8710–8716. doi: 10.1021/ja048805k
Serganov, A., Yuan, Y.-R., Pikovskaya, O., Polonskaia, A., Malinina, L., Phan, A. T., ... Patel, D. J. (2004). Structural basis for discriminative regulation of gene expression by adenine- and guanine-sensing mRNAs. Chemistry & Biology, 11(12), 1729-1741. doi: 10.1016/j.chembiol.2004.11.018
Phan, A. T., Kuryavyi, V., Gaw, H. Y., & Patel, D. J. (2005). Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter. Nature Chemical Biology, 1, 167–173. doi: 10.1038/nchembio723
Phan, A. T., Kuryavyi, V., Luu, K. N., & Patel, D. J. (2007). Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K + solution. Nucleic Acids Research, 35(19), 6517–6525. doi: 10.1093/nar/gkm706
Phan, A. T. (2010). Human telomeric G-quadruplex : structures of DNA and RNA sequences. The FEBS Journal, 277(5), 1107-1117. doi: 10.1111/j.1742-4658.2009.07464.x
Phan, A. T., & Mergny, J.-L. (2002). Human telomeric DNA : G‐quadruplex, i‐motif and Watson–Crick double helix. Nucleic Acids Research, 30(21), 4618–4625. doi: 10.1093/nar/gkf597
Lim, K. W., Amrane, S., Bouaziz, S., Xu, W., Mu, Y., PateL, D. J., ... Phan, A. T. (2009). Structure of the human telomere in K+ solution : a stable basket-type G-quadruplex with only two G-tetrad layers. Journal of the American Chemical Society, 131(12), 4301–4309. doi: 10.1021/ja807503g
Click here for more publications.
Recent Publication:
Devi, G., Winnerdy, F. R., Ang, J. C. Y., Lim, K. W., & Phan, A. T. (2021). Four-layered intramolecular parallel G-quadruplex with non-nucleotide loops : an ultra-stable self-folded DNA nano-scaffold. ACS Nano, 16(1), 533-540.
Patil, K. M., Chin, D., Seah, H. L., Shi, Q., Lim, K. W., & Phan, A. T. (2021). G4-PROTAC : targeted degradation of a G-quadruplex binding protein. Chemical Communications, 57(95), 12816-12819.
Dao, N. T., Haselsberger, R., Khuc, M. T., Phan, A. T., Voityuk, A. A., & Michel-Beyerle, M. E. (2021). Photophysics of DFHBI bound to RNA aptamer Baby Spinach. Scientific Reports, 11(1), 1-9.
Seviour, T., Winnerdy, F. R., Wong, L. L., Shi, X., Mugunthan, S., Foo, Y. H., ... & Kjelleberg, S. (2021). The biofilm matrix scaffold of Pseudomonas aeruginosa contains G-quadruplex extracellular DNA structures. npj Biofilms and Microbiomes, 7(1), 1-12.
Chatain, J., Blond, A., Phan, A. T., Saintomé, C., & Alberti, P. (2021). GGGCTA repeats can fold into hairpins poorly unfolded by replication protein A : a possible origin of the length-dependent instability of GGGCTA variant repeats in human telomeres. Nucleic Acids Research, 49(13), 7588-7601.