Education
BSc. in Chinese Medicine from Heilongjiang University of Chinese Medicine, Harbin, China
MSc. in Chinese Medicine from Heilongjiang University of Chinese Medicine, Harbin, China
Ph.D. in Chinese Medicine from Beijing University of Chinese Medicine, Beijing, China

Research Experience
Senior Lecturer, School of Biological Sciences, NTU
Research Scientist, National University of Singapore
Research Fellow, National Cancer Center, Singapore
Postdoctoral Fellow, Genome Institute of Singapore

Academic and Grant Committees
Co-Chair of TCM Research Grant Committee, MOH
Academic Committee Member, Singapore TCM Practitioners Board,
Research Committee Member, Academy of Chinese Medicine, Singapore,
Members of TCMP Taskforce, MOH
zhaoyan_1_2.JPG picture
Dr Zhao Yan
Senior Lecturer, School of Biological Sciences

The main emphasis of my research is focused on deciphering the signal transduction pathways of drug resistance and apoptosis as it pertains to in cancer biology. Using novel TCM (Traditional Chinese Medicine) herbal extracts and established chemotherapeutic agents, my laboratory is currently working on the signal transduction pathways that are crucial in inducing apoptosis in cancer cells. The role of histone deacetylase, prenylation, methylation and acetylation inhibitors are currently being investigated as therapeutic agents for the treatment of a variety of cancers. In addition, putative proto-oncogenic transcription factors, like those of Kruppel-like family of transcription factors are being investigated for their role in tumorgenesis. In trying to decipher cancer signal transduction pathways, my lab is currently in the process of establishing a first order transcriptional network for these transcription factors. In conjunction with expression profile analysis, we also make use of shRNA libraries, HTS (high-throughput screening) and global transcription factor binding site analysis to answer some of the basic biology underlying drug resistance and apoptosis.

TRADITIONAL CHINESE MEDICINE (TCM) RESEARCH INTEREST
• Anti-cancer effects of extracts prepared from Chinese herbal medicines
• Anti-diabetic effects of extracts prepared from Chinese herbal medicines.
• Toxicity and pharmacokinetic studies on herbal extracts.
• Establish in vivo models for senile dementia and ischemia-reperfusion on rats.
• Patho-physiological studies on a new Chinese medicine therapy for senile dementia.
• Mechanistic studies on ischemia-reperfusion injury.

Current Projects
• Herbalomic: Novel approach for fingerprinting and authentication of herbal products
• A pilot randomized controlled trial of the efficacy of FUling tea concoction and phySical activity advice on body constitution and blood chOlesterol levels among individuals with phlegm-dampNess body constitution. (FUSION)
 
  • A pilot randomized controlled trial of the efficacy of FUling tea concoction and phySical activity advice on body constitution and blood chOlesterol levels among individuals with phlegm-dampNess body constitution (FUSION)
 
  • Zehuan Liao, SiawWen Wong, HanLin Yeo, Yan Zhao. Smart nano carriers for cancer treatment: Clinical impact and safety. NanoImpact, 20 (2020) 100253

  • Khan RMM, Chua ZJY, Tan JC, Yang Y, Liao Z, Zhao Y. From Pre-Diabetes to Diabetes: Diagnosis, Treatments and Translational Research. Medicine. 2019; 55(9):546.

  • Liao Z, Zhao Y. Effect of Heat-Producing Needling Technique on the Local Skin Temperature: Clinical Dataset. Data. 2018; 3(4):65.

  • Fung Foon Yin, Ricky Ang, Koh Hwee Ling, Kun Mei Ching, Lee Lai Heng, Li Xiao Mei, Ng Heng Joo, Tan Chuen Wen, Zhao Yan, Linn Yeh Ching “A Randomized, Double-blind, Placebo- controlled Study on the Anti-haemostatic Effects of Curcuma longa, Angelica sinensis and Panax ginseng" Phytomedicine, 2017 Aug 15;32:88-96. (IF 2.937)

  • Bo-Hwa Choi, Souvik Chattopadhaya, Le Nguyen Thanh, Lin Feng, Quoc Toan Nguyen, Chuan Bian Lim, Amaravadhi Harikishore, Ravi Prakash Reddy Nanga, Nagakumar Bharatham, Yan Zhao, Xuewei Liu, Ho Sup Yoon. Suprafenacine, an Indazole-Hydrazide Agent, Targets Cancer Cells Through Microtubule Destabilization. PLOS ONE 2014, 9 (10)1-13

  • Chuan Bian Lim, Pan You Fu, Nung Ky, Hong Shuang Zhu, XiaoLing Feng, Jinming Li, Kandhadayar Gopalan Srinivasan, Mohamed Sabry Hamza and Yan Zhao. NF-kappaB p65 repression by the sesquiterpene lactone, Helenalin, contributes to the induction of autophagy cell death. BMC Complementary and Alternative Medicine; 2012, 12:93 (11 July 2012)

  • Lim CB, Ky N, Ng HM, Hamza MS and Zhao Y. Curcuma wenyujin extract induces apoptosis and inhibits proliferation of human cervical cancer cells in vitro and in vivo. Integrative Cancer Therapies, 2010,9(1): 36-49.

  • Ky N, Lim CB, Li J, Tam J, Hamza MS and Zhao Y. KLF4 suppresses HDACi induced caspase activation and the SAPK pathway by targeting p57Kip2. Apoptosis, 2009, 14 (9): 1095-1107.

  • Zhao Y, Hamza MS, Leong HS, Lim CB, Pan YF, Cheung E, Soo KC, Iyer NG: Kruppel-like factor 5 modulates p53-independent apoptosis through Pim1 survival kinase in cancer cells. Oncogene 2008, 27:1-8

  • Zhao Y, Tan J, Zhuang L, Jiang X, Liu ET, Yu Q: Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim. Proceedings of the National Academy of Sciences of the United States of America (PNAS) 2005, 102:16090-16095