Academic Profile : Faculty
Professor Ruedl obtained her Doctor of Philosophy in Biology from the University of Innsbruck (Austria) in 1991. After her postdoctoral appointment at the Institute for Experimental Pathology (University of Innsbruck, Austria), she joined 1996 the Basel Institute for Immunology (Basel, Switzerland) as an independent researcher leading her own scientific group. She joined 2001, as a scientific director, Cytos Biotechnology AG (Zuerich, Switzerland) before she was awarded 2004 the Marie Voegtlin Fellowship from Swiss National Science Foundation and moved to the University of Basel. In 2006, she joined Nanyang Technology University ’s School of Biological Sciences in Singapore as an Associate Professor in Immunology where she is currently leading her own research laboratory and teaching the Immunology undergraduate and graduate courses. In 2018 she was promoted to Full Professor and from January 2019 she is the Associate Chair for Research at the School of Biological Sciences.
The research of Professor Ruedl laboratory focuses on the complex myeloid cell family with particular emphasis on dendritic cells (DC) and macrophages. To untangle the role of DC and macrophage cell populations we have constructed a series of novel transgenic mouse strains that can be used to ablate specifically subsets of DC and macrophages in vivo, to define their developmental origins or to regulate cytokine/growth factor gene expression with doxycycline inducible repression. By exploiting these unique transgenic mouse strains, we are particular interested to elucidate the functional specialization of distinct subsets of macrophages and DCs in mediating protective immunity in different infection models, such as influenza and malaria, and in inflammatory conditions, such as gut inflammation. Furthermore, we also study the ontogeny, phenotype and functional contributions of different myeloid cell subpopulations in a preclinical tumor animal model as well as in adipose tissue during obesity development.
- Dynamics, diversity and function of macrophages in adipose tissue
- Is the canonical Wnt signaling pathway transcription factor, Tcf7l2, a potential regulator of sarcopenia during aging?
- Islet macrophages control inflammation and β-cell dysfunction during diabetes.
- The Role of Ezh2-regulated Thymic Dendritic Cells in Thymic Involution
- The Role of Lipid-accumulating Macrophages in Aging and Disease
- Unravelling the function of tissue resident macrophages in health and disease
- Use of encapsulated prebiotic-probiotic to enhance probiotic effects in shrimp farming