Academic Profile


Lescar Julien
Born June 17th, 1966 in Paris
French citizenship
Married, 2 children


1990-1993 Ph.D. (December 1993) Université Paris XI, Orsay
Thesis work performed at the Institut Pasteur, Paris

1989 Master Degree in Physics
1988 B. Sc. Degree in Physics


Since January 2002 School of Biological Science
Nanyang Technological University, Singapore
Assistant Professor (2002)
Associate Professor (2004)

Octobre 1999 Hired as a permanent Scientist (Chargé de Recherches) with C.N.R.S, Université Joseph Fourier, Grenoble

1997-1999 Post-Doctoral Research Fellow
ESRF-EMBL Joint Structural Biology Group, Grenoble.

1995-1996 Post-Doctoral Research Fellow, Institut Pasteur, Paris

1994 Post-Doctoral Research Fellow, Washington University School of Medicine, St Louis, USA.

1990-1993 DEA, Thèse
Département d’Immunologie. Institut Pasteur, Paris
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Prof Julien Lescar
Professor, School of Biological Sciences

Structural Biology
Infectious Diseases
Structure-Based Drug Design
  • Discovering New Target Space for the Development of Drugs Against Malaria Parasites

  • Discovering New Target Space for the Development of Drugs Against Malaria Parasites (Julien Lescar)

  • Functional implication of cytoplasmic EZH2 in cancer stem cells

  • Investigating the Role of HtrA Protease in Antimicrobial-Resistant Gram-Positive Infections

  • Molecular Mechanisms Of Plasmodium Vivax Malaria Parasite Invasion In Reticulocytes

  • Protein Drug target Identifications in Human Malaria Parasites

  • Studying Zika Virus Pathogenesis And The Development Of Therapeutics, In Vitro Cell Culture Model And Mouse Model That Display Various Diseases Phenotypes

  • Targeting PGA1-Nurr1 pathway

  • Viral RNA polymerases from pneumoviruses as molecular machines and as drug targets
  • David Ruiz-Carrillo, Lin Jianqing, Abbas El Sahili, Meng Wei, Siu Kwan Sze, Peter F Cheung, Christian Doerig, and Julien Lescar. (2018). The protein kinase CK2 catalytic domain from Plasmodium falciparum: crystal structure, tyrosine kinase activity and inhibition. Scientific Reports, .

  • Tay, M. Y. F., Saw, W. G., Zhao, Y., Chan, W. K. K., Singh, D, Chong, Y., Forwood, J. K., Ooi, E. E., Grüber, G., Lescar, J., Luo, D., and Vasudevan, S. G. (2015). The C-terminal 50 amino acid residues of Dengue NS3 protein are important for NS3-NS5 interaction and viral replication. Journal of Biological Chemistry, 290, 2379-2394.

  • Alag R, Balakrishna AM, Rajan S, Qureshi IA, Shin J, Lescar J, Grüber G, Yoon HS. (2013). Structural Insights into Substrate Binding by PvFKBP35, a Peptidylprolyl cis-trans Isomerase from the Human Malarial Parasite Plasmodium vivax. Eukaryotic Cell, 12(4), 627-634.

  • Masayo Kotaka#, Rong Kong#, Insaf Qureshi, Qin Shi Ho, Huihua Sun, Chong Wai Liew, Lan Pei Goh, Peter Cheung, Yuguang Mu, Julien Lescar, and Zhao-Xun Liang. (2009). Structure and Catalytic Mechanism of the Thioesterase CalE7 in Enediyne Biosynthesis. Journal of Biological Chemistry, .

  • Rajamanonmani R, Nkenfou C, Clancy P, Yau YH, Shochat SG, Sukupolvi-Petty S, Schul W, Diamond MS, Vasudevan SG, Lescar J. (2009). On a mouse monoclonal antibody that neutralizes all four dengue virus serotypes. Journal of General Virology, 90, 799-809.