Academic Profile : Faculty

julien_1_2.JPG picture
Prof Julien Lescar
Professor, School of Biological Sciences
Director, Nanyang Institute of Structural Biology (NISB)
Interim Director, Nanyang Institute of Structural Biology (NISB)
1.1 CURRICULUM VITAE

Lescar Julien
Born June 17th, 1966 in Paris
French citizenship
Married, 2 children



EDUCATION

1990-1993 Ph.D. (December 1993) Université Paris XI, Orsay
Thesis work performed at the Institut Pasteur, Paris

1989 Master Degree in Physics
1988 B. Sc. Degree in Physics


RESEARCH AND PROFESSIONAL EXPERIENCE




Since January 2002 School of Biological Science
Nanyang Technological University, Singapore
Assistant Professor (2002)
Associate Professor (2004)

Octobre 1999 Hired as a permanent Scientist (Chargé de Recherches) with C.N.R.S, Université Joseph Fourier, Grenoble

1997-1999 Post-Doctoral Research Fellow
ESRF-EMBL Joint Structural Biology Group, Grenoble.

1995-1996 Post-Doctoral Research Fellow, Institut Pasteur, Paris


1994 Post-Doctoral Research Fellow, Washington University School of Medicine, St Louis, USA.

1990-1993 DEA, Thèse
Département d’Immunologie. Institut Pasteur, Paris
Structural Biology
Infectious Diseases
Structure-Based Drug Design
 
  • A Mirror-Image Form of Peptidyl Asparaginyl Ligase for D-Protein Engineering
  • Building and validating a modular vaccination platform via multivalent presentation of antigens using protein-based scaffolds
  • Cryo-EM Structure of Telomere Repeat Binding Factors TRF1 and TRF2 Bound to Telomeric Chromatin
  • Discovering New Target Space for the Development of Drugs Against Malaria Parasites
  • Discovering New Target Space for the Development of Drugs Against Malaria Parasites (Julien Lescar)
  • Phase-Separating Peptides as a General Platform for Intracellular Delivery of Antibody Therapeutics
  • Phase-Separating Peptides as a General Platform for Intracellular Delivery of Antibody Therapeutics - WP2 : Production of Antibodies, Nanobodies, and Antibody Drug Conjugates
  • Structural and biochemical characterization of artemisinin target in malaria parasite
  • Targeting PGA1-Nurr1 pathway
US 2019/0218586 A1: Methods For Enzymatic Peptide Ligation (2023)
Abstract: The present invention relates to a method of ligating a first peptide via its C-terminus to the N-terminus of a second peptide, wherein the reaction is catalyzed by an asparagine/aspartate (Asx) peptide ligase OaAEPI Cys247Ala having the amino acid sequence of SEQ ID NO: 1. Further encompassed are a method of preparing a dimer, oligomer, or multimer of one or more peptides of interest and a method of modifying or tagging the surface of a target cell by one or more peptides of interest. Also encompassed in the invention are the ligated peptides and/or tagged target cells obtainable according to any of the methods, the peptide ligase OaAEPI Cys247Ala having the amino acid sequence of SEQ ID NO: 1, as well as kits comprising said peptide ligase.