Academic Profile : Faculty

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Assoc Prof Thirumaran s/o Thanabalu
Associate Professor, School of Biological Sciences
A/Prof Thirumaran Thanabalu is currently in the School of Biological Sciences which he joined in 2001. He received his BSc(Hon), MSc and Ph.D. degrees from the National University of Singapore. His research interest include Wiskott Aldrich Proteins, WASP, N-WASP and its interacting proteins. He worked as a Post-Doctoral Fellow at IMCB (Singapore), Dept. of Pathology (University of Cambridge), IMA (Singapore) before assuming his position at NTU.

PhD National University of Singapore 1992
MSc National University of Singapore 1990
BSc(Hons) National University of Singapore 1987
The actin cytoskeleton plays an essential role in cell proliferation, migration and differentiation; cellular processes essential for embryogenesis, wound repair, angiogenesis and immune response. Neural-Wiskott-Aldrich Syndrome protein (N-WASP) link multiple signaling pathways to actin cytoskeleton remodeling. Expression of N-WASP has been found to be reduced in early stages of cancer and increased during late staged of cancer, thus N-WASP plays a tumor suppressor and tumor promoter role depending the stage of cancer. We have generated N-WASP floxed mice and using this mice we are characterizing the role of N-WASP in brain development and Cancer (Breast, Lung and Skin). We are also characterizing the role of gut microbiota in skin carcinogenesis.
  • Bioprinting of Porcine Satellite cells mixed with extracelular proteins and Alginate to generate 3D printed pork with meat like properties
  • Cell proliferation inhibitory phospho-ERK2: Characterization of its formation and the pathways regulated by it
  • Characterization of The Role of Gut Microbiota and Immune System in Cancer Immunity of N-WASP Knockout Mice
Nanyang Award 2007: Excellence in Teaching
Courses Taught
BS1007: Molecular and Cell Biology I
BS3342: Role of Actin Cytoskeleton Regulators in Metastasis
Supervision of PhD Students
Have supervised 12 PhD students and 1 MSc student