Academic Profile : Faculty

Assoc Prof Kevin Pethe.jpg picture
Assoc Prof Kevin Pethe
Associate Professor, Infectious Disease and Assistant Dean (Innovation and Enterprise), Lee Kong Chian School of Medicine
Provost's Chair in Infectious Disease
Associate Professor, Lee Kong Chian School of Medicine
Associate Professor, School of Biological Sciences
Associate Professor, Singapore Centre for Environmental Life Sciences Engineering
Journal Articles
(Not applicable to NIE
staff as info will be
pulled from PRDS)
Kalia NP, Hasenoehrl EJ, ... Pethe K. (2017). Exploiting the synthetic lethality betweenterminal respiratory oxidases to kill M. tuberculosis and clear host infection. Proceedings of the National Academy of Sciences. 114(28):7426-31.

Murima P, Zimmermann M, ... Pethe K, et al. (2016). A rheostat mechanism governs the bifurcation of carbonflux in mycobacteria. Nature Communications. 7:12527.

Pethe K, Bifani P, Jang J, et al. (2013). Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. Nature Medicine. 19(9);1157-60.

Mak PA, Srinivasa PSR, ... Pethe K, et al. (2012). A high throughput screen to identify inhibitors of ATP homeostasis innon-replicating Mycobacterium tuberculosis. ACS Chemical Biology. 7(7);1190-7.

Pethe K, Sequeira PC, Agarwalla S, et al. (2010). A chemical genetic screen inMycobacterium tuberculosis identifies carbon-source dependent growth inhibitorsdevoid of in vivo efficacy. Nature Communications. 1:57.

Rao SP, Alonso S, ... Pethe K. (2008). The protonmotive force is required formaintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences. 105(33);11945-50.

Pethe K, Swenson DL, Alonso S, et al. (2004). Isolation of Mycobacterium tuberculosis mutants defective in the arrest of phagosomematuration. Proceedings of the National Academy of Sciences of the United States of America, 101(37), 13642-7.

Temmerman S, Pethe K, Alonso S, et al. (2004). Methylation-dependent Tcell immunity to Mycobacterium tuberculosis heparin-binding hemagglutinin. Nature Medicine. 10(9);935-41.

Pethe K, Bifani P, Drobecq H, et al. (2002). Mycobacterial heparin-binding hemagglutinin and laminin-binding protein shareantigenic methyllysines that confer resistance to proteolysis. Proceedings of the National Academy of Sciences. 99(16);10759-64.

Pethe K, Alonso S, Biet F, et al. (2001). The mycobacterialheparin-binding haemagglutinin adhesion is required for extrapulmonarydissemination. Nature. 412(6843);190-4.