Academic Profile : Faculty

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Asst Prof Christine, Siu Ling, WONG
Nanyang Assistant Professor, Lee Kong Chian School of Medicine
PhD in Physiology – The Chinese University of Hong Kong (2010)
BSc in Biology – The Chinese University of Hong Kong (2006)

Asst Prof Christine Wong is an awardee of the 2018 Nanyang Assistant Professorship, and an Assistant Professor of Metabolic Disorders in Lee Kong Chian School of Medicine. Her research revealed that diabetes predisposes individuals to form neutrophil extracellular traps (NETs), the cytotoxic chromatin released by activated neutrophils. She also identified the first detrimental implication of NETs in diabetes: impaired wound healing.

Asst Prof Wong was awarded numerous honours, including the Higher Education Outstanding Scientific Research Output Award (Second-Class Award), Ministry of Education, People’s Republic of China (2018), Young Investigator Award of the International Society on Thrombosis and Haemostasis (2013), and the prestigious Postgraduate Research Output Award of the Chinese University of Hong Kong (2010). Asst Prof Wong was an invited speaker of conferences and seminars, including at the National Institutes of Health, USA (2018), and in the Heidelberg International Symposium on Diabetic Complications, Germany (2016). She is a co-inventor of a pending patent regarding the use of anti-NET compounds in facilitating wound healing.
Originally described to trap and kill microbes, neutrophil extracellular traps (NETs) are increasingly recognized to form in sterile inflammation, causing unfavourable collateral damages to the body. Asst Prof Wong’s research programme aims to explore the mechanisms of enhanced NET formation in diabetes, pathophysiology of diabetic complications from the NET perspective, and NET-microbiota interaction in metabolic disorders. Her long-term research goal is to translate novel basic science findings to clinical applications, so as to promote healthy ageing by curtailing chronic inflammatory conditions.
  • Circulating microRNA as novel biomarkers for vascular health profiling in type 2 diabetes mellitus (LKCMed-MiRXES Service Grant)
  • Elevated NETosis in diabetes: Dynamics of subcellular structures and the metabolic basis
  • Neutrophil Digital Twin (NeuDT): A multi-parametric biophysical cell model to predict cardiovascular risk in Type 2 Diabetes Mellitus