Academic Profile : Faculty

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Assoc Prof Hou Han Wei
Associate Professor, School of Mechanical & Aerospace Engineering
Associate Professor, Lee Kong Chian School of Medicine
Associate Professor, Lee Kong Chian School of Medicine (Courtesy Appointment)
Assistant Chair (Students), School of Mechanical and Aerospace Engineering (MAE)
 
Dr. Han Wei Hou is an Associate Professor at the School of Mechanical and Aerospace Engineering (MAE), and Lee Kong Chian School of Medicine (LKCMedicine) at Nanyang Technological University (NTU). He is also an Adjunct Senior Research Scientist at Tan Tock Seng Hospital (TTSH). Dr. Hou received his BEng (First Class Hons) and PhD degree in Biomedical Engineering at the National University of Singapore in 2008 and 2012, respectively. Upon graduation, he did his postdoctoral training at Massachusetts Institute of Technology (USA), and subsequently joined LKCMedicine as the inaugural LKCMedicine Postdoctoral Fellow in 2014. His research interest is in developing microfluidics (lab-on-a-chip) technologies for point-of-care blood diagnostics and biosensing. He has authored over 50 peer-reviewed journal publications and filed 12 patents/patent applications (2 are licensed to MedTech companies). His recent research awards and accolades include International Academy of Medical and Biological Engineering (IAMBE) Early Career Award (2022), NTU College of Engineering Research – Young Faculty Special Mention (2022), IFMBE Asia-Pacific Research Networking (APRN) Fellowship (2022), ISAC Innovators (2021), Lab on a Chip Emerging Investigators (2019), Interstellar Initiative Early Career Investigators (2018), and LKCMedicine Postdoctoral Research Fellowship (2014).

Research group website: http://www.hwhoulab.com
-Microfluidics for blood diagnostics and cell purification
-Label-free point-of-care immunoassays using impedance cytometry
-Circulating extracellular vesicles as novel biomarkers for non-invasive vascular health profiling
-Biomimetic microengineered human organ-on-chip platforms for personalized medicine
- Biomanufacturing and cell-based therapy
 
  • CellFACE – Imaging-based flow cytometry for hidden haematology biomarker
  • Circulating microRNA as novel biomarkers for vascular health profiling in type 2 diabetes mellitus (LKCMed-MiRXES Service Grant)
  • ExoArc: Microfluidic Automated Blood Processing for Liquid Biopsy
  • Exploring the mechanism of action of different stimuli in NETosis
  • Gram+ bacteria derived nanovesicles as new vaccine and antibiotic resistance
  • IMC Compartmentalization and its role in maturation and transmission of P. falciparum gametocytes
  • Microfluidic in-line process analytical technologies (PAT) and automated cell harvesting for bioreactors in cell manufacturing
  • Microfluidics approaches to assess thrombosis and inflammation risks in RNA therapeutics
  • Neutrophil Digital Twin (NeuDT): A multi-parametric biophysical cell model to predict cardiovascular risk in Type 2 Diabetes Mellitus
  • Project RESET: Redirecting immune, lipid and metabolic drivers of early cardiovascular disease
  • REducing Diabetic macrovascUlar Complications duE to Peripheral Arterial Disease - REDUCE-PAD
  • Uncovering the Mechanical Coupling of Nanoparticle and Extracellular Matrix Elasticities for Enhanced Tumor Targeting
US 2019/0217291A1: Three-Dimensional (3D) Hydrogel Patterning In Microfluidic Vascular Models (2023)
Abstract: The present disclosure provides a device for patterning extracellular matrix (ECM) hydrogel comprising a first layer surface patterned to define a microchannel, a second layer comprising a loading channel in fluid communication with loading ports to receive an ECM hydrogel, wherein the first layer is attached over the second layer such that the patterned surface faces the loading channel to define an open chamber with regions of reduced cross-sectional area, and wherein the ECM hydrogel is confined to fill said regions, thereby forming a perfusable channel in the open chamber.
Awards
International Academy of Medical and Biological Engineering (IAMBE) Early Career Award (2022)
NTU College of Engineering Research – Young Faculty Special Mention (2022) IFMBE Asia-Pacific Research Networking (APRN) Fellowship (2022)
ISAC Innovators (2021)
Lab on a Chip Emerging Investigators (2019)
Interstellar Initiative Early Career Investigators (2018)
 
Fellowships & Other Recognition
LKCMedicine Postdoctoral Research Fellowship (2014)
 
Courses Taught
MA2003 Introduction to Thermofluids
MA2007 Thermodynamics
MA3010 Thermodynamics and Heat Transfer
MA3071 Engineering Experiments (E3.5 Heat exchanger)