• Oliver Meldrum PhD, LKCMedicine-Imperial College London Postdoctoral Fellow
• Fransiskus Xaverius Ivan, PhD, Senior Post-doctoral Research Fellow
• Tavleen Kaur Jaggi, MBBS, MD, Post-doctoral Research Fellow
• Thng Kai Xian, BSc, Research Assistant
• Jayanth Kumar Narayana, PhD Student
• Valerie Yong Fei Lee, PhD Student
Associate Professor Sanjay Haresh Chotirmall graduated from the Royal College of Surgeons in Ireland (RCSI) with an honours degree and the colleges’ gold medal in Microbiology. He completed his early clinical training at Beaumont Hospital Dublin, while attaining memberships of the Royal College of Physicians of Ireland (MRCPI) and the United Kingdom (MRCP UK). Following this, he completed higher specialist training in Respiratory and Critical Care Medicine across multiple hospital sites in the Republic of Ireland.
In 2007, Assoc Prof Chotirmall was awarded a prestigious ‘Molecular Medicine Ireland Clinician Scientist Fellowship’ (MMI-CSF). During this fellowship, he completed a PhD investigating the role of estrogen in cystic fibrosis. This work led to high impact publications in the American Journal of Respiratory and Critical Care Medicine (AJRCCM), as well as the New England Journal of Medicine (NEJM).
Assoc Prof Chotirmall has been awarded the Royal Academy of Medicine of Ireland (RAMI) Doctor award on two occasions (2010 & 2013), the Irish Thoracic Society Award (2011), the Dublin Centre for Clinical Research (DCCR) Young Investigator Award (2011), the MMI-CSFP Medal (2011), the Royal College of Physicians William Stokes Award for research (2010) and the American Thoracic Societies International Award (2009). Additionally, his work has been recognised by the Faculty of 1000 Biology and Medicine, an online research service that highlights critical papers published in the biological sciences, as recommended by distinguished faculty. In 2018, he was conferred as fellow of the Royal College of Physicians in Ireland (FRCPI), in 2019 as Fellow of the American College of Chest Physicians (FCCP) and in 2020 a fellow of the Royal College of Physicians of the United Kingdom (London). In 2020, he was awarded the inaugural Dean’s Award for Research at LKCMedicine and the Alumni Award for ‘Research and Innovation’ by the Royal College of Surgeons in Ireland (RCSI). In collaboration with a team of clinicians at Tan Tock Seng Hospital (TTSH), Assoc Prof Chotirmall secured the NHG Research Impact Award (2021) for his work in bronchiectasis, a chronic irreversible lung disease of high Asian prevalence.
Having published numerous peer-reviewed papers, and several book chapters to date, he is regularly invited as chair and speaker at regional, national, and international meetings. He remains a member of the International Society of Human and Animal Mycology (ISHAM) working group for fungal infections, was a steering committee member for the ATS-led international taskforce on COVID-19 management and participates in various other committees at the American Thoracic Society (ATS) and European Respiratory Society (ERS). He previously served for four consecutive years (2016-2020) on the program committee of the American Thoracic Society (ATS) annual congress for the Assembly on Allergy, Immunology, and Inflammation (AII).
Assoc Prof Chotirmall holds several editorial roles at the American Journal of Respiratory and Critical Care Medicine (Associate Editor), the European Respiratory Journal (Editorial Board), Respiratory Research (Associate Editor), the American Journal of Physiology-Lung Cellular and Molecular Physiology (Editorial Board), Respirology (Associate Editor), npj Primary Care Respiratory Medicine (Associate Editor), Mycopathologia (Executive Editor), Frontiers in Pharmacology (Associate Editor) and PLos One (Academic Editor). He was Section Editor at BMC Pulmonary Medicine from 2013 to 2020 where he led a team of Associate Editors under the ‘Infectious, Rare and Idiopathic Pulmonary Disease’ section. Assoc Prof Chotirmall regularly participates as an investigator for key multi-centre clinical trials in the field of Respiratory Medicine while continuing to educate undergraduates and postgraduates through formal teaching and supervision both at the bench and bedside. He has been appointed by the National University of Ireland (NUI) as the external examiner for the Perdana University-Royal College of Surgeons in Ireland (PU-RCSI) MBBS programme from 2020-2023.
As a recognised clinician-scientist, Assoc Prof Chotirmall has established a Translational Respiratory Research Group, with focus on infection, inflammation, and immunity, in the context of chronic inflammatory respiratory diseases and the lung microbiome that affect Asian populations.
Research in the Chotirmall lab shares a core translational respiratory focus with a common goal to improve patient care through advancing the understanding of disease from a scientific basis. The group pursues research in a number of areas with significant clinical importance that impact Singaporeans and other Asian populations;
Chronic inflammatory lung disease
The group investigates the basic mechanisms of clinical relevance in a number of pulmonary conditions including bronchiectasis, chronic obstructive pulmonary disease (COPD) and severe asthma. A major focus is on the investigation of bronchiectasis, a permanent and irreversible dilatation of the airway of high prevalence across Asia. Utilising genomic and molecular approaches combined with high-quality clinical phenotyping, geographic variation in this disease state are elucidated and a personalised approach to clinical manifestations and associated therapeutic responses are explored.
Infectious respiratory disease and the pulmonary microbiome
Central to the lab’s focus is infectious respiratory disease including the pulmonary microbiome. Specifically, how the fungi Aspergillus fumigatus and bacteria Pseudomonas aeruginosa affect major Asian respiratory disease states such as bronchiectasis, COPD and severe asthma are explored. The lab has developed novel data science approaches to integrate microbiome datasets: https://integrative-microbiomics.ntu.edu.sg to allow for translation and patient risk-stratification. The environmental influence on pulmonary infection in chronic respiratory disease states is also a major interest of the Chotirmall lab.
- Bedside to bench and back again: evaluating Neisseria spp.as novel respiratory pathobionts using systems biology
- Indoor air microbiomes as a gateway to exposome-guided precision medicine for respiratory disease
- Lung Organoids: A tool of the fourth industrial revolution to study COVID-19 pathogenesis
- Molecular mechanism of antibiotic resistance conferred by ribosome protection protein
- Proposed Establishment of the Academic Respiratory Initiative for Pulmonary Health programme
- Provost's Chair in Molecular Medicine (Sanjay H. Chotirmall)
- There is no place like home": Indoor air microbiomes and respiratory disease - a fresh approach to 'exposome' precision medicine"
- Mac Aogáin M*, Narayana JK*, Tiew PY….Chotirmall SH. (2021). Integrative microbiomics in bronchiectasis exacerbations. Nat Med. doi: 10.1038/s41591-021-01289-7.
- Chotirmall SH, Martinez FJ, Schumacker PT, Cooke CR, Seam N, Brochard L, Tighe RM, Levy BD, Gern D, Wedzicha JA. (2020). Life at the Editorial "COVID Frontline". The American Thoracic Society Journal Family. Am J Respir Crit Care Med. 15;201(12):1457-1459. doi: 10.1164/rccm.202005-1516ED.
- Tiew PY, Ko FWS, Narayana JK….Chotirmall SH. (2020). "High-Risk" Clinical and Inflammatory Clusters in COPD of Chinese Descent. Chest. 22:S0012-3692(20)30326-3. doi: 10.1016/j.chest.2020.01.043. Online ahead of print.PMID: 32092320.
- Mac Aogáin M, Lau KJX…Tsaneva-Atanasova K, Schuster SC, Chotirmall SH. (2020). Metagenomics Reveals a Core Macrolide Resistome Related to Microbiota in Chronic Respiratory Disease. Am J Respir Crit Care Med. doi: 10.1164/rccm.201911-2202OC. Online ahead of print.PMID: 32320621.
- Vidaillac C*, Yong VFL*, Aschtgen MS, Qu J…..Normark S, Henriques-Normark B, Chotirmall SH. (2020). Sex Steroids Induce Membrane Stress Responses and Virulence Properties in Pseudomonas aeruginosa. mBio 2020 Sep 29;11(5):e01774-20. doi: 10.1128/mBio.01774-20.
- Bai C, Chotirmall SH, Rello J et al (2020) Updated guidance on the management of COVID-19: from an American Thoracic Society/European Respiratory Society coordinated International Task Force (29 July 2020) Eur Respir Rev 2020 Oct 5;29(157):200287. doi: 10.1183/16000617.0287-2020. PMID: 33020069
- Tiew PY, Dicker AJ, Keir HR….Miller BE, Tal-Singer R, Chalmers JD, Chotirmall SH. (2020) A high-risk airway mycobiome is associated with frequent exacerbation and mortality in COPD. Eur Respir J. 2020 Sep 24:2002050. doi: 10.1183/13993003.02050-2020.
- Mac Aogáin M, Tiew PY….Chotirmall SH. (2018). Distinct ‘Immuno-Allertypes’ of disease and high frequencies of sensitisation in non-cystic fibrosis bronchiectasis. American Journal of Respiratory and Critical Care Medicine. doi:10.1164/rccm.201807-1355OC.
- Chalmers JD, Chotirmall SH. (2018). Bronchiectasis: new therapies and new perspectives. Lancet Respiratory Medicine, 6(9), 715-726.
- Mac Aogáin M, Chandrasekaran R…Chotirmall SH. (2018). Immunological corollary of the pulmonary mycobiome in bronchiectasis: the CAMEB study. European Respiratory Journal, 52(1), pii 1800766.
- Chotirmall SH, Smith SG, Gunaratnam C, et al. (2012). Effect of estrogen on pseudomonas mucoidy and exacerbations in cystic fibrosis. The New England Journal of Medicine, 366(21):1978-86.
- *Complete list of publications: PubMed
1. Cystic fibrosis breakthrough reveals why females fare worse than males (Science Daily)
2. Breathing a little easier
3. Scientists make major cystic fibrosis breakthrough
4. Royal College of Physicians of Ireland Announce Winner of 2010 William Stokes Award
5. Meet the editors at ATS Journals
6. COVID‐19: Interim Guidance on Management Pending Empirical Evidence. From an American Thoracic Society‐led International Task Force
7. Singapore’s NTU launches nationwide research initiative to promote lung health
8. NTU Singapore Launches Nationwide Lung Health Initiative
9. The Academic Respiratory Initiative for Pulmonary Health (TARIPH)
10. NTU probes link between tiny air organisms and respiratory woes
11. Sanjay Chotirmall - Research and Innovation Award 2020