Academic Profile : Faculty

Prof Wang Yulan_1.jpg picture
Prof Wang Yulan
Professor, Metabolomics and Director of Singapore Phenome Centre, Lee Kong Chian School of Medicine
Professor, Lee Kong Chian School of Medicine

Dr Low Yanwen Dorrain

Professor Wang Yulan is a professor of Metabolomics at LKCMedicine and Director of Singapore Phenome Centre (SPC). She also has an honorary appointment with the School of Public Health at Imperial College London.

Prof Wang obtained her PhD in Physical Chemistry in 1997 from University of East Anglia, UK. After her PhD, Prof Wang joined the Institute of Food Research and John Innes Center, UK, where she spent 1998 to 2001 on postdoctoral research, applying her Nuclear Magnetic Resonance (NMR) skills in food sciences. From 2001 to 2007, Prof Wang worked at Imperial College London, in the field of metabonomics as research fellow. In 2007, she was recruited as part of China’s “1000 talents program” by the Chinese Academy of Science and became a professor at the Wuhan Institute of Physics and Mathematics. She used NMR and Liquid Chromatography – Mass Spectrometry (LC-MS) spectroscopic techniques with computational modelling techniques to investigate the metabolic effects of infectious diseases and nutritional interventions.
Prof Wang believes that advances in research rely on the breakthrough of new technology. She will focus her research on developing metabonomics techniques, including NMR and MS-based techniques. Quantitatively detecting as many metabolites as possible with the highest sensitivity and throughput is the ultimate goal of metabolic profiling. Since cell-to-cell variability can contribute to antibiotic resistance and cancer re-occurrence, measurement of single cells metabolomics at high throughput becomes necessary to elucidate new mechanisms in health and diseases. Development of high throughput single cell metabolomics is one her current focus. In addition, Prof Wang is interested in metabolic impact of infectious diseases, such as HBV infection, co-infections and gut microbial-host interactions. Furthermore, metabonomics is a very useful tool for generating credible hypotheses that can be applied to many other areas, such as gastroenterological diseases, cancer, metabolic diseases, neurodegenerative diseases, drug resistance and environmental sciences as well as dietary studies. Prof Wang is interested in collaboration with scientists in these fields.

Finally, the important role of preventive medicine in health management relies on detecting the onset of disease. Metabolic alteration during onset of disease could be detected using metabolomics tools; therefore, applications of metabolomics on population phenotyping and detecting early onset of a range of chronical diseases, such as diabetes and coronary heart disease is one of another area of interest.
  • Advancing precision medicine for cardiovascular disease and diabetes in Asian populations
  • Building a fluxomic toolkit for strain improvement, with application to scCO2-tolerant Bacillus SR7 as a novel platform organism for bioproduction
  • Changes in circulating metabolites following bariatric surgery impacts diabetes remission rates through the control of insulin secretion.
  • Connect choline deficiency during pregnancy with unfolded protein response and Alzheimer diseases
  • Developing Metabolic Phenotyping Technologies Capitalising On The Use Of Both NMR And Mass Spectrometer
  • Early detection of hepatocellular carcinoma (HCC): miRNA, microbiome and imaging biomarkers in the evolution of chronic liver disease in a high-risk prospective cohort
  • Engineering Scaffold-Mediated Neural Cell Therapy for Spinal Cord Injury Treatment
  • Engineering Scaffold-Mediated Neural Cell Therapy for Spinal Cord Injury Treatment (Astar)
  • Engineering Scaffold-Mediated Neural Cell Therapy for Spinal Cord Injury Treatment (NTU)
  • Investigating effects of Roseburia intestinalis on colorectal carcinogenesis and its dietary modulation for cancer prevention
  • Is the canonical Wnt signaling pathway transcription factor, Tcf7l2, a potential regulator of sarcopenia during aging?
  • Maximization of choline bioavailability for targeted nutrition
  • Mechanisms of Progesterone Antagonism of Estrogen Action on the Endometrium
  • Precision Medicine in Liver Cancer across an Asia-Pacific Network 2.0 (PLANet 2.0)
  • Proteins4Singapore
  • Understanding Allergens in Alternative Food from Urban Aquaculture Fish to Underpin Food Safety
  • Understanding Allergens in Alternative Food from Urban Aquaculture Fish to Underpin Food Safety (PI: Wang Yulan)