Academic Profile

Professor Lim Kah Leong is Vice-Dean (Research), who leads the strategic development and implementation of the School’s research programme. He is also a President’s Chair in Translational Neuroscience. Professor Lim works closely with the Dean and the senior leadership of LKCMedicine, NTU and Imperial College London to advance institutional initiatives for research excellence.

Professor Lim obtained his Ph.D. from the Singapore Institute of Molecular & Cell Biology in 1999. Thereafter, he did his postdoctoral training firstly at the Department of Pathology in Harvard Medical School (2000-2001), and subsequently at the Department of Neurology in Johns Hopkins University School of Medicine (2001-2002) where he worked on the topic of Parkinson’s disease with Professor Ted Dawson.

Prior to joining LKCMedicine, Professor Lim was Head of the Department of Physiology at the National University of Singapore Yong Loo Lin School of Medicine and Deputy Research Director at the National Neuroscience Institute. Professor Lim has received numerous awards including the prestigious (Singapore) President’s Science Award (Team) and the Singapore Neuroscience Association Distinguished Neuroscientist Award.
Lim KL.png picture
Prof Lim Kah Leong
Professor and Vice Dean (Research)
Professor, Lee Kong Chian School of Medicine
Research Director (Biomedical and Life Sciences), Nanyang Technological University

Professor Lim is a renowned scientist in the areas of neuroscience and mental health, particularly in the field of Parkinson’s Disease. With a long-term goal to elucidate the molecular events underlying Parkinson’s Disease and to effectively treat the disease, his research centres on mechanisms underlying neurodegeneration, which will reveal targets for neuroprotection. He is also developing new research technologies in the area of stem cells and neurorestoration as well as in diagnostics and neurotechnology, where he collaborates extensively with chemists, materials scientists and engineers. His laboratory uses a broad range of disease models including Drosophila, rodents, human neurons and brain organoids generated from patient-derived induced pluripotent stem cells and non-human primates (marmosets).

  • Engineering Scaffold-Mediated Neural Cell Therapy for Spinal Cord Injury Treatment

  • Engineering Scaffold-Mediated Neural Cell Therapy for Spinal Cord Injury Treatment (Astar)

  • Human Umbilical Cord-Lining Derived Induced Pluripotent StemCells (CLiPS) as a Universal Source of Cells for Regenerative Therapy for Neurosensory Disorders

  • Neuroprotective Strategies for Parkinson's disease

  • Proposed Establishment of a Zebrafish Facility at theLee Kong Chian School of Medicine at EMB in Yunnan Garden Campus

  • Study Early Asymptomatic Molecular Pathology Of Neurodegeneration In Dementia: Proteomic Identification Of Priority Drug Targets (TUG)

  • Study Early Asymptomatic Molecular Pathology Of Neurodegeneration In Dementia: Proteomic Identification Of Priority Drug Tragets
  • Jo, J., Yang, L., Tran, H., Yu, W., Yang, L., Sun, A., Chang, Y.Y., Jung, B.C., Lee, S.J., Saw, T.Y, Xiao, B., Khoo, A.T.T., Yaw, L.P., Xie, J.J., Lokman, H., Ong, W.Y., Lim, G.Y., Lim, K.L.*, Tan, E.K.*, Ng, H.H.*, Je, S.* (*co-corresponding) (2021) Lewy-body like Inclusions in Human Midbrain Organoid Carrying Glucocerebrosidase and Alpha Synuclein mutations. Annals of Neurology (In Press) (PMID: 34288055)

    Teh, B., Bansal, A., Chai, C., Toh, T.B., Jappy Tucker, R.A., Gammad, G.G.L., Yeo, Y., Lei, Z., Zheng, X., Feng, Y., Ho, J., Bolem, N., Wu, B.C., Gnanasammandhan, M.K., Hooi, L., Dawe, G.S., Libedinsky, C., Ong, W.Y., Halliwell, B., Chow, E.K.H., Lim, K.L.*, Zhang, Y.*, Kennedy, B*. (*co-corresponding) (2020) Flexi-PEGDA Upconversion Implant for Wireless Brain Photodynamic Therapy. Advanced Materials, Jul;32(29):e2001459 (PMID: 32484308)

    Rajan S, Jang Y, Kim CH, Kim W, Toh HT, Jeon J, Song B, Serra A, Lescar J, Yoo JY, Beldar S, Ye H, Kang C, Liu XW, Feitosa M, Kim Y, Hwang D, Goh G, Lim K.L., Park HM, Lee CH, Oh SF, Petsko GA, Yoon HS, Kim KS (2020). PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function. Nature Chemical Biology, Aug;16(8):876-886 (PMID: 32451509)

    Sun, A.X., Yuan, Q., Fukuda, M., Yu, W., Yan, H.D., Lim, G.G.Y., Nai, H.H., D'Agostino G.A., Tran, H., Itahana, Y., Wang, D., Lokman, H., Itahana, K., Lim, S.W.L., Tang, J., Cook, S.A., Rackham, Lim, C.T., Tan, E.K., Ng, H.H., Lim, K.L., Jiang, Y., Je, S. (2019). Potassium channel dysfunction in human neuronal models of Angelman syndrome. Science, 366 (6472): 1486:1492. (PMID: 31857479)

    Lim, G.G. and Lim, K.L. (2017). Parkin-independent Mitophagy-FKBP8 takes the stage. EMBO Reports, 18(6):864-865 (PMID: 28515082)

    Ng, C.H., Basil, A.H., Hang, L.T., Tan, R., O’Neill S., Zhang, X.D., Yu, F., Lim, K.L. (2017). Genetic or pharmacological activation of the Drosophila PGC-1α ortholog spargel rescues the disease phenotypes of genetic models of Parkinson’s disease. Neurobiology of Aging, 55:33-37. (PMID: 28407521)

    Nucifora, F.C., Nucifora, L.G., Ng, C.H., Arbez, N., Guo, Y., Roby, E., Shani, V., Engelender, S., Wei, D., Wang, X.F., Li, T., Moore DJ, Pletnikova, O., Troncoso, J., Sawa, A., Dawson, T.M., Smith, W., Lim, K.L., Ross, C.A. (2016). Ubiqutinationvia K27 and K29 chains signals aggregation and neuronal protection of LRRK2 byWSB1. Nature Communications, 7:11792. (PMID: 27273569)

    Li, L., Zhang C.W., P., Chen G.Y.J., Zhu, B., Y.W., Chai. C., Xu, Q., Tan, E.K., Kung, S.K.P., Lim, K.L.*, Yao, S.Q. (*co-corresponding). (2014). A sensitive two-photon probe to selectively detect monoamine oxidase B activity in Parkinson’s disease models. Nature Communications, 5:3276. (PMID: 24522637)