Academic Profile : Faculty

Lim KL.png picture
Prof Lim Kah Leong
Associate Vice President (Biomedical & Life Sciences), Lee Kong Chian School of Medicine
President's Chair in Translational Neuroscience
Professor, Lee Kong Chian School of Medicine
Journal Articles
(Not applicable to NIE
staff as info will be
pulled from PRDS)
Koh, D.H.Z., Naito, T., Na, M., Yeap, Y.J., Rozario, P., Zhong, F., Lim, K.L., Saheki, Y. (2023) Visualization of accessible cholesterol using a GRAM domain-based biosensor. Nature Communication, Oct 25;14(1):6773 (2023)

Tang, W., Thundyil, J., Sean, Q.Z. Yeow, Nair, A., Lim, G.G., Chai, C., Yao, T.P., Lim, K.L. (2022) Parkin regulates neuronal lipid homeostasis through SREBP2-lipoprotein lipase pathway. Human Molecular Genetics Apr 20;32(9):1466-1482

Jo, J., Yang, L., Tran, H., Yu, W., Yang, L., Sun, A., Chang, Y.Y., Jung, B.C., Lee, S.J., Saw, T.Y, Xiao, B., Khoo, A.T.T., Yaw, L.P., Xie, J.J., Lokman, H., Ong, W.Y., Lim, G.Y., Lim, K.L.*, Tan, E.K.*, Ng, H.H.*, Je, S.* (*co-corresponding) (2021) Lewy-body like Inclusions in Human Midbrain Organoid Carrying Glucocerebrosidase and Alpha Synuclein mutations. Annals of Neurology, Sep;90(3):490-505 ) (PMID: 34288055)

Teh, B., Bansal, A., Chai, C., Toh, T.B., Jappy Tucker, R.A., Gammad, G.G.L., Yeo, Y., Lei, Z., Zheng, X., Feng, Y., Ho, J., Bolem, N., Wu, B.C., Gnanasammandhan, M.K., Hooi, L., Dawe, G.S., Libedinsky, C., Ong, W.Y., Halliwell, B., Chow, E.K.H., Lim, K.L.*, Zhang, Y.*, Kennedy, B*. (*co-corresponding) (2020) Flexi-PEGDA Upconversion Implant for Wireless Brain Photodynamic Therapy. Advanced Materials, Jul;32(29):e2001459 (PMID: 32484308)

Rajan S, Jang Y, Kim CH, Kim W, Toh HT, Jeon J, Song B, Serra A, Lescar J, Yoo JY, Beldar S, Ye H, Kang C, Liu XW, Feitosa M, Kim Y, Hwang D, Goh G, Lim K.L., Park HM, Lee CH, Oh SF, Petsko GA, Yoon HS, Kim KS (2020). PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function. Nature Chemical Biology, Aug;16(8):876-886 (PMID: 32451509)

Sun, A.X., Yuan, Q., Fukuda, M., Yu, W., Yan, H.D., Lim, G.G.Y., Nai, H.H., D'Agostino G.A., Tran, H., Itahana, Y., Wang, D., Lokman, H., Itahana, K., Lim, S.W.L., Tang, J., Cook, S.A., Rackham, Lim, C.T., Tan, E.K., Ng, H.H., Lim, K.L., Jiang, Y., Je, S. (2019). Potassium channel dysfunction in human neuronal models of Angelman syndrome. Science, 366 (6472): 1486:1492. (PMID: 31857479)

Lim, G.G. and Lim, K.L. (2017). Parkin-independent Mitophagy-FKBP8 takes the stage. EMBO Reports, 18(6):864-865 (PMID: 28515082)

Ng, C.H., Basil, A.H., Hang, L.T., Tan, R., O’Neill S., Zhang, X.D., Yu, F., Lim, K.L. (2017). Genetic or pharmacological activation of the Drosophila PGC-1α ortholog spargel rescues the disease phenotypes of genetic models of Parkinson’s disease. Neurobiology of Aging, 55:33-37. (PMID: 28407521)

Nucifora, F.C., Nucifora, L.G., Ng, C.H., Arbez, N., Guo, Y., Roby, E., Shani, V., Engelender, S., Wei, D., Wang, X.F., Li, T., Moore DJ, Pletnikova, O., Troncoso, J., Sawa, A., Dawson, T.M., Smith, W., Lim, K.L., Ross, C.A. (2016). Ubiqutinationvia K27 and K29 chains signals aggregation and neuronal protection of LRRK2 byWSB1. Nature Communications, 7:11792. (PMID: 27273569)

Li, L., Zhang C.W., P., Chen G.Y.J., Zhu, B., Y.W., Chai. C., Xu, Q., Tan, E.K., Kung, S.K.P., Lim, K.L.*, Yao, S.Q. (*co-corresponding). (2014). A sensitive two-photon probe to selectively detect monoamine oxidase B activity in Parkinson’s disease models. Nature Communications, 5:3276. (PMID: 24522637)