Dr. Tong Ling joined the School of Chemical and Biomedical Engineering (SCBE) at Nanyang Technological University in January 2021. Before that, he was a postdoctoral fellow in the Department of Ophthalmology and Hansen Experimental Physics Laboratory at Stanford University. He received his Ph.D. in 2016 and B.Eng. in 2011 from Zhejiang University. He develops interferometric imaging techniques for a wide range of applications across multiple fields, including biomedical imaging, optical metrology, and applied physics. He invented the randomly encoded hybrid grating for versatile quadriwave lateral shearing interferometry, which was nominated for 2015 China’s Top 10 Optical Breakthroughs by the Chinese Journal of Lasers. He also received the Wang Daheng Optics Award by the Chinese Optical Society, the top award for young researchers in optics and photonics in China. Recently, his research in full-field interferometric imaging of action potentials demonstrated a new approach to functional neuroimaging using optical phase signals, opening the door to all-optical non-fluorescent techniques for functional imaging in the retina and the brain.
• All-optical imaging of neural electrical activity
• Optoretinogram: In-vivo functional imaging of the human retina
• Single-molecule imaging
• Thermometry for non-damaging retinal laser therapy
• High-resolution wavefront sensing/diagnosis
- High-speed interferometric imaging of retinal function at the cellular scale
- Nanoparticle-enhanced high-speed interferometric scattering microscopy for nanoscopic live cell imaging
V. P. Pandiyan, A. Maloney-Bertelli, J. Kuchenbecker, K. C. Boyle, T. Ling, Z. C. Chen, B. H. Park, A. Roorda, D. Palanker and R. Sabesan, “The optoretinogram reveals the primary steps of phototransduction in the living human eye,” Science Advances 6, eabc1124 (2020).
T. Ling*, K. C. Boyle*, V. Zuckerman, T. Flores, C. Ramakrishnan, K. Deisseroth and D. Palanker, “High-speed interferometric imaging reveals dynamics of neuronal deformation during the action potential,” Proceedings of the National Academy of Sciences (PNAS) 117, 10278-10285 (2020).
T. Ling, K. C. Boyle, G. Goetz, P. Zhou, Y. Quan, F. S. Alfonso, T. W. Huang and D. Palanker, “Full-field interferometric imaging of propagating action potentials,” Light: Science & Applications 7, 107 (2018).
G. Goetz*, T. Ling*, T. Gupta, S. Kang, J. Wang, P. D. Gregory, B. H. Park, and D. Palanker, “Interferometric mapping of material properties using thermal perturbation,” Proceedings of the National Academy of Sciences (PNAS) 115, E2499-E2508 (2018).
T. Ling, D. Liu, X. Yue, Y. Yang, Y. Shen, and J. Bai, “Quadriwave lateral shearing interferometer based on a randomly encoded hybrid grating,” Optics Letters 40, 2245-2248 (2015).