Academic Profile

Academic Qualifications
1988-1991 Ph. D. in Public Health, University Pierre and Marie Curie (Paris, France)

Current Position
Professor, Lee Kong Chian School of Medicine.
Joint appointment with School of Biological Sciences, NTU, Singapore

Awards
1991 McArthur Foundation (USA), research fellowship award
1992 Stanley Foundation (Switzerland), research fellowship award
1991 Institut Electricité et Santé [Electricité de France (EDF) Science Foundation], Research Grant Award
2009 A*STAR (Singapore) Safety Advocates Award (2009)
2010 2012 A*STAR (Singapore) Dedicated Service Award (2012)
2018 Ministry of Health, Singapore, 5-year long service Award
2019 Ministry of Trade and Industry (MTI) awards 2019. Borderless Bronze award
2021 Knight of the Insignia of Merit, French Republic
Laurent Renia1 (1).jpg picture
Prof Laurent Renia
Professor of Infectious Diseases, Lee Kong Chian School of Medicine
Professor, Lee Kong Chian School of Medicine

My scientific interests cover the immunology of infectious diseases (malaria and arboviruses) and newly emerging viruses (SARS-CoV-2) to the development of new immunological assays and animal models that can be used to study communicable and non-communicable diseases (such as cancer).
 
  • 1. Malleret B, El Sahili A, Tay MZ, Carissimo G, Ong ASM, Novera W, Lin J, Suwanarusk R, Kosaisavee V, Chu TTT, Sinha A, Howland SW, Fan Y, Gruszczyk J, Tham WH, Colin Y, Maurer-Stroh S, Snounou G, Ng LFP, Chan JKY, Chacko AM, Lescar J, Chandramohanadas R, Nosten F, Russell B, Rénia L. Plasmodium vivax binds host CD98hc (SLC3A2) to enter immature red blood cells. Nature Microbiology. 2021. In press. doi: 10.1038/s41564-021-00939-3.
    2. Leong YW, Lee EQH, Renia L*, Malleret B*. Data-driven analysis of COVID-19 reveals specific severity patterns distinct from the temporal immune response. Frontiers in Cellular and Infection Microbiology 11, 680136, 2021.
    3. Asarnow D, Wang B, Lee WH, Hu Y, Huang CW, Faust B, Ng PML, Ngoh EZX, Bohn M, Bulkley D, Pizzorno A, Ary B, Tan HC, Lee CY, Binte Minhat RA, Terrier O, Soh MK, Teo FJ, Yeap YYC, Seah SGK, Maurer-Stroh S, Rénia L, Hanson BJ, Rosa-Calatrava M, Manglik A, Cheng Y, Craik CS, Wang C. Structural insights into antibody inhibition of SARS-CoV-2 infectivity and syncytia formation. Cell 184, 3192-3204.
    4. Chan YH, Fong SW, Poh CM, Carissimo G, Yeo NKW, Amrun SN, Goh YS, Lim J, Xu W, Chee RSL, Torres-Ruesta A, Lee CYP, Tay MZ, Chang ZW, Wang B, Lee WH, Tan SY, Kalimuddin S, Young BE, Leo YS, Wang CI, Lee B, Rötzschke O, Lye DC, Renia L, Ng LFP. Asymptomatic COVID-19: disease tolerance with efficient anti-viral immunity against SARS-CoV-2. EMBO Molecular Medicine 13, e14045, 2021.
    5. Goh YS, Chavatte JM, Jieling AL, Lee B, Amrun SN, Lee CYP, Chee RSL, Wang B, Lee CY, Ngoh EZX, Wang CI, Young BE, Tambyah PA, Kalimuddin S, Pada S, Tan SY, Sun LJ, Chen MIC, Leo YS, Lye DCB, Ng LFP, Lin RTP, Rénia L. Sensitive detection of total anti-Spike antibodies and isotype switching in asymptomatic and symptomatic COVID-19 patients. Cell Reports Medicine 2, 100193, 2021.
    6. Perico L, Benigni A, Casiraghi F, Ng LFP, Renia L, Remuzzi G. Immunity, endothelial injury, and complement-induced coagulopathy in COVID-19. Nature Reviews Nephrology 17, 46-64, 2021.
    7. Windpessl M, Bruchfeld A, Anders HS, Kramer H, Waldman M, Renia L, Ng LFP, Xing Z, Kronbichler A. COVID-19 vaccines and kidney disease. Nature Reviews Nephrology 17, 2921-293, 2021.
    8. Rénia L, Grau GER, Wassmer SC. CD8+ T cells and human cerebral malaria: a shifting episteme. Journal of Clinical Investigations 130, 1109-1011, 2020.
    9. Torres-Ruesta A, Teo TH, Chan YH, Rénia L, Ng LFP. Pathogenic Th1 responses in CHIKV-induced inflammation and their modulation upon Plasmodium parasites co-infection. Immunology Reviews 294, 80-91, 2020.
    10. Amrun SN, Lee CYP, Lee B, Fong SW, Young BE, Chee RSL, Yeo NKW, Torres-Ruesta A, Carissimo G, Poh CM, Chang ZW, Tay MZ, Chan YH, Chen MIC, Tambyah PA, Kalimuddin S, Pada S, Tan SY, Sun LJ, Leo YS, Lye DC, Renia L, Ng LFP. Antibody profiling of COVID-19 patients identified 4 linear B-cell epitopes in the spike and nucleocapsid proteins as markers of SARS-CoV-2 exposure and disease severity. eBiomedicine 58, 102911, 2020.
    11. Poh CM, Carissimo G, Wang B, Amrun SN, Lee CYP, Chee RSL, Fong SW, Yeo NKW, Lee WH, Torres-Ruesta A, Leo YS, Chen MC, Tan SY, Chai LYA, Kalimuddin S, Shirley SGH, Thien SY, Young BE, Lye DC, Hanson BJ, Wang CI, Rénia L, Ng LFP. Two linear epitopes on the SARS-CoV-2 spike protein that elicit neutralising antibodies in COVID-19 patients. Nature Communications 11, 2806, 2020.
    12. Lee WL, Russell BM, Sobota RM, Ghaffar K, Howland SW, Wong ZX, Maier AG, Dorin-Semblat D, Biswas SK, Gamain B, Lau YL, Chu C, Nosten F, Rénia L. Plasmodium-infected erythrocytes induce secretion of IGFBP7 to form type II rosettes and escape phagocytosis. eLife 9, e51546, 2020.
    13. Tay MZ, Poh CM, Rénia L, Macary PA, Ng LFP. The trinity of COVID-19: Immunity, Inflammation, and Intervention. Nature Reviews Immunology 20, 262-274, 2020.
    14. Claser C, Nguee SYT, Balachander A, Howland SW, Becht E, Gunasegaran B, Hartimath S, Ho JT, Ong CB, Newell E, Goggi J, Ng LG, Rénia L. Lung endothelial cell antigen cross-presentation to CD8+T cells drives malaria-associated lung injury. Nature Communications. 10, 4241, 2019.
    15. Gruszczyk J, Chan LJ, Kanjee U, Menant S, Malleret B, Lim NTY, Schmidt CQ, Mok YF, Lin KM, Smith B, Call MJ, Weekes MP, Griffin MDW, Murphy JM, Abraham J, Kanlaya S, Russell BM, Rénia L, Duraisingh M, Tham WH. Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax. Science 359, 48-55, 2018.