Academic Profile

After completing my undergraduate in biology, I took the opportunity to pursue my interest in bioinformatics which is a marriage of my love for biology and computer science. My training in my Ph.D. program provided me with an excellent chance to dive deeper into computer science with working in a biology department. This has instilled in me the need to apply computational methods in a biologically meaningful manner so as to better explain the biology at play. I then took up a high throughput curation position at The Blueprint Initiative Asia where I was involved in the curation of the BIND protein protein interaction database for high throughput screening data like yeast two hybrid systems and synthetic lethal screens. The experience here showed me the value of a well-organized team with specialized functional groups each performing its best in its domain. I learnt the value of teamwork, the need for effective communication and the value of large data sets like that curated in BIND. The very scale and complexity of the data required new methodologies in its curation and analysis. I also learnt to appreciate the important of having a strong IT team to provide the necessary infrastructure to support the computational work. With the closing of the Blueprint Initiative Asia due to the end of the grant, I moved over to the Bioinformatics Institute in A*STAR as part of a team supporting bioinformatics analysis to the institute as well as other research institute within A*STAR. Here the exposure to different types of biology reinforced the need to comprehend the biology to better support our collaborators. I also explored the creation of web-based platforms that are appealing to researchers due to the ease of access and use.

After a short stint at Thomson Reuters working on further improvements to the BIND protein protein interaction database, which was acquired by Thomson Reuters, I had the opportunity to work at Eli Lilly. This was an excellent chance to see how a very large organization performed research and development. In such a large organization, there is the luxury of having very capable specialists tackling specific area of work and I have learnt much from these experts and gained an appreciation of how to organize a team from various functional units together to fulfil project objectives. Unfortunately, the ever-changing industry climate led to a closure of the center in Singapore, and I joined the Singapore Immunology Network (SIgN) as a bioinformatics scientist supporting the research activities conducted in the institute. The various experiences gained over the years has really allowed me to excel in this position. The recognition of the necessity for collaborative work, good communication and clear understanding of the biology domain has resulted in numerous collaborations which have produced numerous scientific publications. While joint publications are a good indicator of success, another indicator is the support and appreciation that we have gotten from the rest of the research groups in SIgN. The Computational Immunology group at SIgN which I led not only works with internal research groups, but also with other groups in the local landscape. I think this is a clear sign that the work that we do makes an impact. Recently I moved to LKCMedicine where I hope to leverage on my experience and expertise to create a Centre for Biomedical Informatics that will support and value add to the excellent research done at LKCMedicine.
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Dr Bernett Lee
Assistant Professor of Biomedical Informatics and Director, Centre for Biomedical Informatics, Lee Kong Chian School of Medicine
Assistant Professor, Lee Kong Chian School of Medicine

Data management and analysis
Integrative data analytics
  • Carissimo, Guillaume, Weili Xu, Immanuel Kwok, Mohammad Yazid Abdad, Yi-Hao Chan, Siew-Wai Fong, Kia Joo Puan, Cheryl Yi-Pin Lee, Nicholas Kim-Wah Yeo, Siti Naqiah Amrun, Rhonda Sin-Ling Chee, Wilson How, Stephrene Chan, Bingwen Eugene Fan, Anand Kumar Andiappan, Bernett Lee, Olaf Rötzschke, Barnaby Edward Young, Yee-Sin Leo, David Chien Lye, Laurent Renia, Lai Guan Ng, Anis Larbi, and Lisa Fp Ng. “Whole Blood Immunophenotyping Uncovers Immature Neutrophil-to-vd2 T-Cell Ratio as an Early Marker for Severe Covid-19.” Nat Commun 11, no. 1 (2020): 5243.

  • Yeong, Joe, Tira Tan, Zi Long Chow, Qing Cheng, Bernett Lee, Amanda Seet, Johnathan Xiande Lim, Jeffrey Chun Tatt Lim, Clara Chong Hui Ong, Aye Aye Thike, Sahil Saraf, Benjamin Yong Cheng Tan, Yong Cheng Poh, Sidney Yee, Jin Liu, Elaine Lim, Jabed Iqbal, Rebecca Dent, and Puay Hoon Tan. “Multiplex Immunohistochemistry/immunofluorescence (Mihc/if) for Pd-L1 Testing in Triple-Negative Breast Cancer: A Translational Assay Compared With Conventional Ihc.” J Clin Pathol (2020):

  • Chao, Yin Xia, Bernett Lee, Ebonne Yulin Ng, Michelle Mulan Lian, Elaine Guo Yan Chew, Moses Tandiono, Zheng Li, Chiea Chuen Khor, Prakash Kumar, Louis C S Tan, Jia Nee Foo, and Eng-King Tan. “Association Analysis of Psap Variants in Parkinson’s Disease Patients.” Brain (2020):

  • Monaco, Gianni, Bernett Lee, Weili Xu, Seri Mustafah, You Yi Hwang, Christophe Carré, Nicolas Burdin, Lucian Visan, Michele Ceccarelli, Michael Poidinger, Alfred Zippelius, João Pedro de Magalhães, and Anis Larbi. “RNA-Seq Signatures Normalized By Mrna Abundance Allow Absolute Deconvolution of Human Immune Cell Types.” Cell Rep 26, no. 6 (2019): 1627–1640.e7.

  • Kumar, Dilip, Bernett Lee, Kia Joo Puan, Wendy Lee, Boris San Luis, Nurhashikin Yusof, Anand Kumar Andiappan, Ricardo Del Rosario, Jeremie Poschmann, Pavanish Kumar, Gennaro DeLibero, Amit Singhal, Shyam Prabhakar, Wang De Yun, Michael Poidinger, and Olaf Rötzschke. “Resistin Expression in Human Monocytes is Controlled By Two Linked Promoter Snps Mediating Nfkb P50/p50 Binding and C-Methylation.” Sci Rep 9, no. 1 (2019): 15245.