Academic Profile : Faculty

D379FA4F-FD01-4E83-8672-1D5E09011585_1_201_a_1.jpeg picture
Asst Prof Kazuyuki Kasahara
Assistant Professor, Metabolic, Nutrition, and Microbiome Medicine, Lee Kong Chian School of Medicine
Assistant Professor, Lee Kong Chian School of Medicine
Journal Articles
(Not applicable to NIE
staff as info will be
pulled from PRDS)
Debédat J, Le Roy T, Voland L, Belda E, Alili R, Adriouch S, Bel Lassen P, Kasahara K, Hutchison E, Genser L, Torres L, Gamblin C, Rouault C, Zucker JD, Kapel N, Poitou C, Marcelin G, Rey FE, Aron-Wisnewsky J, Clément K. The human gut microbiota contributes to type-2 diabetes non-resolution 5-years after Roux-en-Y gastric bypass. Gut Microbes. 2022;14(1):2050635

Kasahara K, Rey FE. The emerging role of gut microbial metabolism on cardiovascular disease. Curr Open Microbiol. 2019;50:64-70

Kasahara K, Krautkramer KA, Org E, Romano KA, Kerby RL, Vivas EI, Mehrabian M, Denu JM, Båckhed F, Lusis AJ, Rey FE. Interactions between Roseburia intestinalis and diet modulate atherogenesis in a murine model. Nature Microbiology. 2018;3(12):1461-1471

Cross TL, Kasahara K, Rey FE. Sexual dimorphism of cardiometabolic dysfunction: Gut microbiome in the play? Mol Metab. 2018;15:70-81

Romano KA, Dill-McFarland KA, Kasahara K, Kerby RL, Vivas EI, Amador-Noguez D, Herd P, Rey FE. Fecal Aliquot Straw Technique (FAST) allows for easy and reproducible subsampling: assessing interpersonal variation in trimethylamine-N-oxide (TMAO) accumulation. Microbiome. 2018;6(1):91

Romano KA*, Martinez-del Campo A*, Kasahara K, Chittim CL, Vivas EI, Amador-Noguez D, Balskus EP, Rey FE. Metabolic, Epigenetic, and Transgenerational Effects of Gut Bacterial Choline Consumption. Cell Host and Microbe. 2017;22(3):279-290.e7. *equally contributed.

Hayashi T, Sasaki N, Yamashita T, Mizoguchi T, Emoto T, Amin HZ, Yodoi K, Matsumoto T, Kasahara K, Yoshida N, Tabata T, Kitano N, Fukunaga A, Nishigori C, Rikitake Y, Hirata KI. Ultraviolet B Exposure Inhibits Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Mice by Expanding CD4+Foxp3+ Regulatory T Cells. Journal of the American Heart Association. 2017;6:e007024.

Mizoguchi T*, Kasahara K*, Yamashita T, Sasaki N, Yodoi K, Matsumoto T, Emoto T, Hayashi T, Kitano N, Yoshida N, Amin HZ, Hirata KI. Oral administration of the lactic acid bacterium Pediococcus acidilactici attenuates atherosclerosis in mice by inducing tolerogenic dendritic cells. Heart Vessels. 2017;32(6):768-776. *equally contributed.

Kasahara K, Tanoue T, Yamashita T, Yodoi K, Matsumoto T, Emoto T, Mizoguchi T, Hayashi T, Kitano N, Sasaki N, Atarashi K, Honda K, Hirata KI. Commensal bacteria at the crossroad between cholesterol homeostasis and chronic inflammation in atherosclerosis. Journal of Lipid Research. 2017;58(3): 519-528.

Sasaki N, Yamashita T, Kasahara K, Fukunaga A, Yamaguchi T, Emoto T, Yodoi K, Matsumoto T, Nakajima K, Kita T, Takeda M, Mizoguchi T, Hayashi T, Sasaki Y, Hatakeyama M, Taguchi K, Washio K, Sakaguchi S, Malissen B, Nishigori C, Hirata KI. UVB Exposer Prevents Atherosclerosis by Regulating Immunoinflammatory Responses. Arteriosclerosis, Thrombosis, and Vascular Biology. 2017;37(1):66-74.

Emoto T, Yamashita T, Kobayashi T, Sasaki N, Hirota Y, Hayashi T, So A, Kasahara K, Yodoi K, Matsumoto T, Mizoguchi T, Ogawa W, Hirata KI. Characterization of gut microbiota profiles in coronary artery disease patients using data mining analysis of terminal restriction fragment length polymorphism; gut microbiota could be a diagnostic marker of coronary artery disease. Heart Vessels. 2017;32(1):39-46.

Matsumoto T, Sasaki N, Yamashita T, Emoto T, Kasahara K, Mizoguchi T, Hayashi T, Yodoi K, Kitano N, Saito T, Yamaguchi T, Hirata KI. Overexpression of Cytotoxic T-Lymphocyte-Associated Antigen-4 Prevents Atherosclerosis in Mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 2016;36(6):1141-51.

Emoto T, Yamashita T, Sasaki N, Hirota Y, Hayashi T, So A, Kasahara K, Yodoi K, Matsumoto T, Mizoguchi T, Ogawa W, Hirata KI. Analysis of Gut Microbiota in Coronary Artery Disease Patients: A Possible Link between Gut Microbiota and Coronary Artery Disease. Journal of Atherosclerosis and Thrombosis. 2016; 23(8):908-21.

Yodoi K, Yamashita T, Sasaki N, Kasahara K, Emoto T, Matsumoto T, Kita T, Sasaki Y, Mizoguchi T, Tim Sparwasser, Hirata K. Foxp3+ Regulatory T Cells play a protective role in angiotensin Ⅱ-induced aortic aneurysm formation in mice. Hypertension. 2015;65(4):889-95

Emoto T, Sasaki N, Yamashita T, Kasahara K, Sasaki Y, Yodoi K, Mizoguchi T, Hirata K. The regulatory / effector T cell ratio is reduced in coronary artery disease. Circulation Journal. 2014;78(12):2935-41

Kasahara K, Sasaki N, Yamashita T, Kita T, Yodoi K, Sasaki Y, Takeda M, Hirata K. CD3 antibody and IL-2 complex combination therapy inhibits atherosclerosis by augmenting a regulatory immune response. Journal of the American Heart Association. 2014;3(2):e000719

Kita T, Yamashita T, Sasaki N, Kasahara K, Sasaki Y, Yodoi K, Takeda M, Nakajima K, Hirata K. Regression of atherosclerosis with anti-CD3 antibody via augmenting a regulatory T cell response in mice. Cardiovasc Research. 2014;102(1):107-117

Nakajima K, Yamashita T, Kita T, Takeda M, Sasaki N, Kasahara K, Shinohara M, Rikitake Y, Ishida T, Yokoyama M, Hirata K. Orally administered eicosapentaenoic acid induces rapid regression of atherosclerosis via modulating the phenotype of dendritic cells in LDL receptor-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 2011;31:1963-1972
Google Scholar