Academic Profile : Faculty

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Prof Alain Ange Marie Filloux
Director, Singapore Centre for Environmental Life Sciences Engineering (SCELSE)
Professor, School of Biological Sciences
Professor, Lee Kong Chian School of Medicine
Professor Alain Filloux completed his master’s degree in cellular and molecular biology, and PhD in molecular biology and microbiology from Aix-Marseille University, France. He is centre director of the Singapore Centre for Environmental Life Sciences Engineering (SCELSE) and holds appointments at both the School of Biological Sciences and the Lee Kong Chian School of Medicine at NTU. Prior to his appointment, Alain Filloux was a visiting professor in NTU since 2017. In his previous post at Imperial College London, UK, he had a chair in Molecular Microbiology at the Department of Life Sciences and was the deputy director of the MRC Centre for Molecular Bacteriology and Infection.

Alain Filloux is an expert in bacterial infection biology, with the aim of translating fundamental and basic research into strategies for preventing and treating bacterial diseases. He has profound expertise in bacterial biofilms, bacterial virulence factors and protein secretion systems, and bacterial communication and signalling.

To date, he has published 180 peer reviewed papers and has been an invited speaker at more than 85 major international conferences, including Gordon Research Conferences (GRC) and American Society for Microbiology meetings.

Alain Filloux has been the editor-in-chief of FEMS Microbiology Reviews, and npj Biofilms and Microbiomes, a partnership between the Nature Partner Journals and NTU, with SCELSE as the journal’s scientific partner. He holds editorial positions at Frontiers in Cellular and Infection Microbiology, microLife, and the Journal of Biological Chemistry. He has also been elected Fellow of the European Academy of Microbiology, the American Academy of Microbiology, and the Royal Society of Biology.
Our research project aims to tackle the problem of persistence and chronic infection by Pseudomonas aeruginosa. P. aeruginosa is a gram-negative bacterium found in various environments including soil, water and vegetation. Importantly it is an opportunistic human pathogen, responsible for numerous nosocomial infections in immuno-compromised patients. These infections are fatal in cystic fibrosis patients.

Our project follows several research lines, which deal with essential molecular mechanisms involved in biofilm formation and type VI protein secretion. These two key processes are co-regulated and highly relevant for P. aeruginosa pathogenesis. The regulatory control involves signalling pathways associated with two-component regulatory systems and the intracellular second messenger c-di-GMP. We address these questions using multi-disciplinary approaches in molecular microbiology, genetics, cellular microbiology, structural biology and biochemistry.
 
  • Cluster 4 - Public Health
  • Pseudomonas biofilm and pathogenesis
Awards
2004 Coup d’élan 2003” Bettencourt-Schueller foundation.
2006 Medical Research Foundation (FRM), Piraud award for research on infectious diseases.
2007 The Royal Society Wolfson Research Merit award.
 
Fellowships & Other Recognition
2016 Elected a member of the European Academy of Microbiology (EAM)
2017 Elected a fellow of the American Academy of Microbioloy (AAM)
2019 Elected a fellow of the Royal Society of Biology (FRSB)