Academic Profile : Faculty

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Asst Prof Loh Jia Tong
Assistant Professor, School of Biological Sciences
Journal Articles
(Not applicable to NIE
staff as info will be
pulled from PRDS)
Loh JT*, Teo JKH, Kannan S, Verma C, Andiappan A, Lim HH, Lam KP*. Dok3-PP4c complex negatively regulates Card11 signaling in T cells and affects severity of atopic dermatitis. Science Signaling. (2023) (*Co-corresponding author) (Manuscript accepted)

Loh JT, Teo JKH, Kannan S, Verma C, Lim HH, Lam KP. Disrupting Dok3-Card9 interaction with synthetic peptides enhances antifungal effector functions of human neutrophils. Pharmaceutics. (2023). doi: 10.3390/pharmaceutics15071780

Loh JT* and Lam KP*. Fungal infections: Immune defense, immunotherapies and vaccines. Adv. Drug Deliv. Rev. (2023). doi: 10.1016/j.addr.2023.114775 (*Co-corresponding author)

Loh JT*, Teo JKH, Lam KP*. Dok3 restrains neutrophil production of calprotectin during TLR4 sensing of SARS-CoV-2 spike protein. Front. Immunol. (2022). doi: 10.3389/fimmu.2022.996637 (*Co-corresponding author)

Loh JT, Zhang B, Teo JKH, Lai RC, Choo ABH, Lam KP, Lim SK. Mechanism for the attenuation of neutrophil and complement hyperactivity by MSC exosomes. Cytotherapy. (2022) doi:10.1016/j.jcyt.2021.12.003.

Loh JT, Lee KG, Lee AP, Teo JKH, Lim HL, Kim SSY, Tan AHM, Lam KP. DOK3 maintains intestinal homeostasis by suppressing JAK2/STAT3 signaling and S100a8/9 production in neutrophils. Cell Death Dis. 12, 1054 (2021). doi: 10.1038/s41419-021-04357-5

Wang X, Lin X, Zheng Z, Lu B, Wang J, Tan AHM, Zhao M, Loh JT, Ng SW, Chen Q, Xiao F, Huang En, Ko K, Huang Z, Li J, Kok K, Lu G, Liu X, Lam KP, Liu W, Zhang Y, Yuen K, Mak TW, Lu L. Host-derived lipids orchestrate pulmonary gdT cell response to provide early protection against influenza virus infection. Nat. Commun. 12, 1914(2021).

Loh JT*, Teo JKH, Lim HH and Lam KP*. Emerging roles of Downstream of Kinase 3 in cell signaling. Front. Immunol. (2020) 11:566192. doi: 10.3389/fimmu.2020.566192 (*Co-corresponding author)

Loh JT, Xu S, Huo JX, Kim SS, Wang Y, Lam KP. Dok3-protein phosphatase 1 interaction attenuates Card9 signaling and neutrophil-dependent antifungal immunity. J Clin Investigat. (2019) 129:2717-29. doi: 10.1172/jci126341

Loh JT, TJF Lim, K Ikumi, T Matoba, B Janela, M Gunawan, T Toyama, M Bunjamin, LG Ng, M Poidinger, A Morita, F Ginhoux, S Yamazaki, KP Lam, IH Su. Ezh2 controls skin tolerance through distinct mechanisms in different subsets of skin dendritic cells. iScience. (2018) 10:23-39. doi: 10.1016/j.isci.2018.11.019

Gunawan M*, Venkatesan N*, Loh JT*, Wong JF, Berger H, Neo WH, Li LY, La Win MK, Yau YH, Guo T, See PCE, Yamazaki S, Chin KC, Gingras A, Shochat SG, Ng LG, Sze SK, Ginhoux F, Su IH. The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin. Nat. Immunol. (2015) 16:505-516. doi: 10.1038/ni.312 (*co-first author)