Academic Profile : Faculty
Prof Kristijan Ramadan
Professor of Cancer and Stem Cell Biology, Lee Kong Chian School of Medicine
Toh Kian Chui Distinguished Professor in Cancer and Stem Cell Biology
Professor, Lee Kong Chian School of Medicine
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Kristijan Ramadan is the Director of the Developmental Biology & Regenerative Medicine Programme at Lee Kong Chian School of Medicine (LKCMedicine) and the Toh Kian Chui Distinguished Professor of Cancer and Stem Cell Biology at Nanyang Technological University (NTU), Singapore. He is also an Honorary Senior Research Scientist and Medical Research Council (MRC) Investigator at the Department of Oncology, University of Oxford, UK.
Before joining LKCMedicine, Kristijan was a Full Professor of Molecular Medicine at the University of Oxford and an MRC Investigator at the Department of Oncology.
Kristijan holds degrees in Veterinary Medicine (DVM) and veterinary pathology (MSc), as well as a PhD in biochemistry and molecular biology under the supervision of Prof Dr Ulrich Hübscher. He did his post-doctoral training at the ETH-Zürich (Swiss Federal Institute of Technology) in the group of Dr Hemmo Meyer. Between 2009 and 2013, he was Junior Group Leader and Lecturer at the Institute of Pharmacology and Toxicology-Vetsuisse, University of Zürich. In 2013, he moved to the UK to join the Department of Oncology as MRC Senior Group leader. From 2014 to 2019, he was an Associate Professor at the Department of Oncology, University of Oxford. In 2019, Kristijan was promoted to the Full Professor of Molecular Medicine at the University of Oxford. In 2024, he took a chair position in Cancer and Stem Cell Biology at LKCMedicine, NTU, Singapore.
Kristijan received the Proud of Croatia Award (Croatian Hero for 2014) for his scientific co-contribution to saving the life of a young boy who had liver cancer caused by mutations in the SPRTN gene.
Kristijan's research has made significant contributions to Medicine. His work has led to the codiscoveries of Chromatin-Associated Degradation, DNA-Protein Crosslink Proteolysis Repair, and Ruijs-Aalfs Syndrome (RJALS), all of which have had a profound impact on our understanding and treatment of various medical conditions, including cancer and ageing.
In 2020, Kristijan was elected to the Croatian Academy of Sciences and Arts (HAZU) as a distinguished scientist in Medicine.
In 2024, Nanyang Technological University awarded him the Toh Kian Chui Distinguished Cancer and Stem Cell Biology Professorship to lead a research programme and provide leadership and mentorship to take LKCMedicine to the frontiers of research.
Before joining LKCMedicine, Kristijan was a Full Professor of Molecular Medicine at the University of Oxford and an MRC Investigator at the Department of Oncology.
Kristijan holds degrees in Veterinary Medicine (DVM) and veterinary pathology (MSc), as well as a PhD in biochemistry and molecular biology under the supervision of Prof Dr Ulrich Hübscher. He did his post-doctoral training at the ETH-Zürich (Swiss Federal Institute of Technology) in the group of Dr Hemmo Meyer. Between 2009 and 2013, he was Junior Group Leader and Lecturer at the Institute of Pharmacology and Toxicology-Vetsuisse, University of Zürich. In 2013, he moved to the UK to join the Department of Oncology as MRC Senior Group leader. From 2014 to 2019, he was an Associate Professor at the Department of Oncology, University of Oxford. In 2019, Kristijan was promoted to the Full Professor of Molecular Medicine at the University of Oxford. In 2024, he took a chair position in Cancer and Stem Cell Biology at LKCMedicine, NTU, Singapore.
Kristijan received the Proud of Croatia Award (Croatian Hero for 2014) for his scientific co-contribution to saving the life of a young boy who had liver cancer caused by mutations in the SPRTN gene.
Kristijan's research has made significant contributions to Medicine. His work has led to the codiscoveries of Chromatin-Associated Degradation, DNA-Protein Crosslink Proteolysis Repair, and Ruijs-Aalfs Syndrome (RJALS), all of which have had a profound impact on our understanding and treatment of various medical conditions, including cancer and ageing.
In 2020, Kristijan was elected to the Croatian Academy of Sciences and Arts (HAZU) as a distinguished scientist in Medicine.
In 2024, Nanyang Technological University awarded him the Toh Kian Chui Distinguished Cancer and Stem Cell Biology Professorship to lead a research programme and provide leadership and mentorship to take LKCMedicine to the frontiers of research.
- Toh Kian Chui Distinguished Professor in Cancer and Stem Cell Biology
- Chromatin-associated degradation (CHROMAD) as a druggable target for cancer therapy and/or overcoming drug resistance
Awards
Awards as a Main Applicant
1. 2023-2026 Breast Cancer Now Award
2. 2022-2027 Medical Research Council Programme Award
3. 2020-2023 Breast Cancer Now Award
4. 2017-2022 Medical Research Council Programme Award
5. 2017-2021 Lab282 Drug Discovery Partnership Award
6. 2016 CRUK-Oxford Centre Development Fund Award
7. 2014 CRUK-Oxford Centre Development Fund Award
8. 2013-2017 Medical Research Council Programme Award
9. 2012-2015 Swiss National Science Award
10. 2011-2013 Swiss Life Project Award
11. 2009 Novartis Biomedical Sciences Project Award
12. 2009-2011 University of Zurich Start-up Award
13. 2006 Roche Postdoctoral Award
Awards as a Co-Applicant
1. 2012-2017 Swiss Cancer Research Project Award with Prof H. Naegeli
2. 2009-2011 Swiss Cancer Research Project Award with Prof U. Hubscher
1. 2023-2026 Breast Cancer Now Award
2. 2022-2027 Medical Research Council Programme Award
3. 2020-2023 Breast Cancer Now Award
4. 2017-2022 Medical Research Council Programme Award
5. 2017-2021 Lab282 Drug Discovery Partnership Award
6. 2016 CRUK-Oxford Centre Development Fund Award
7. 2014 CRUK-Oxford Centre Development Fund Award
8. 2013-2017 Medical Research Council Programme Award
9. 2012-2015 Swiss National Science Award
10. 2011-2013 Swiss Life Project Award
11. 2009 Novartis Biomedical Sciences Project Award
12. 2009-2011 University of Zurich Start-up Award
13. 2006 Roche Postdoctoral Award
Awards as a Co-Applicant
1. 2012-2017 Swiss Cancer Research Project Award with Prof H. Naegeli
2. 2009-2011 Swiss Cancer Research Project Award with Prof U. Hubscher
Fellowships & Other Recognition
The Toh Kian Chui Distinguished Professorship Award (2024-2029)
Medical Research Council (UK) Investigator (2020-2027)
Corresponding Member of the Croatian Academy of Sciences and Arts (Since 2020)
Award for Exceptional Scientific Contribution of Alumni, Veterinary Medicine Faculty, Croatia (2019)
The Full Professor of Molecular Medicine at the University of Oxford (2019)
The Proud of Croatia Award (Croatian Hero 2014); for his scientific co-contribution to the role of the SPRTN gene/protein in cancer and ageing.
Medical Research Council (UK) Investigator (2020-2027)
Corresponding Member of the Croatian Academy of Sciences and Arts (Since 2020)
Award for Exceptional Scientific Contribution of Alumni, Veterinary Medicine Faculty, Croatia (2019)
The Full Professor of Molecular Medicine at the University of Oxford (2019)
The Proud of Croatia Award (Croatian Hero 2014); for his scientific co-contribution to the role of the SPRTN gene/protein in cancer and ageing.
Supervision of PhD Students
Current PhD/DPhil students and their thesis titles:
16) 2023-2027 Sara Tribble (Oxford). Regulation of selective autophagy by post-translational modifications.
15) 2023-2027 Yichen (Amy) Zhao (Oxford). The Protein Degradation system regulates the adaptive immune response.
14) 2022-2026 Stelios (Alex) Koukouravas (Oxford). MRN complex disassembly.
13) 2020-2024 Gwendoline Hoslett (Oxford). The role of the p97 system in the repair of cytotoxic trapped PARP1.
12) 2019-2024 Pauline Lascaux (Oxford). TEX264 orchestrates selective autophagy of DNA lesions.
11) 2019-2024 Ftoon Aljarbou (Oxford). Repair of ionizing-radiation induced DNA-protein crosslinks.
Graduated PhD/DPhil or DVM students; their thesis titles and the following job destinations:
10) 2019-2023 D.Phil (Oxford) Cristiano Peron. The role of SPRTN protease in colorectal carcinoma therapy. Cristiano runs his own start-up company and is the Chief Medical Officer of Oxbridge Clinical, Boston, USA.
9) 2017-2022 D.Phil. (Oxford) Susan Kilgas. p97/VCP regulates MRE11-dependent DNA end resection and alters cellular toxicity of ionising radiation. Susan took a post-doctoral position at the Dana-Farber Cancer Institute, Harvard Medical School, USA.
8) 2017-2022 D.Phil. (Oxford) Shudong Li. Dual role of p97 in DNA damage repair. The Francis Crick Institute, London.
7) 2016-2021 D.Phil. (Oxford) Sam Hume. The role of NUCKS in DNA repair. Sam has enrolled in the postgraduate Medical School Programme at the University of Oxford.
6) 2015-2019 D.Phil. (Oxford) John Fielden. The p97 system regulates Topoisomerase 1-cleavage complex repair. John has moved to the Swiss Federal Institute of Technology (ETH-Zurich) as a post-doctoral fellow.
5) 2014-2017 D.Phil. (Oxford) Katherine Wiseman; Characterization of a new p97 adaptor in genome stability. Dr. Wiseman has since moved to Immunocore Ltd, Oxford, as a scientist.
4) 2012-2016 D.Phil. (Oxford) Swagata Halder; The role of p97 cofactors SPRTN and FAF1 in DNA replication. Dr. Halder received a prestigious long-term EMBO postdoctoral fellowship and moved to the lab of Prof. V Costanzo, IFOM, Milan, Italy.
3) 2012-2016 D.Phil. (Oxford) Judith Oehler; Orchestration of the ubiquitin-dependent DNA damage response by the p97 system. Dr. Oehler has since started her postdoctoral position in the lab of Prof. M. Whitby, Institute of Biochemistry, University of Oxford.
2) 2011-2013 D.V.M. (Zurich) Sebastian Koller; Chromatin-associated protein degradation: influence of p97/VCP on key factors in DNA damage response.
1) 2009 -2010 D.V.M. (Zurich) Matthias Bosshard; Involvement of the AAA ATPase p97/VCP in DNA metabolism. Dr. Bosshard was awarded the best DVM thesis in Switzerland for 2010 and started his PhD at the University of Zurich.
16) 2023-2027 Sara Tribble (Oxford). Regulation of selective autophagy by post-translational modifications.
15) 2023-2027 Yichen (Amy) Zhao (Oxford). The Protein Degradation system regulates the adaptive immune response.
14) 2022-2026 Stelios (Alex) Koukouravas (Oxford). MRN complex disassembly.
13) 2020-2024 Gwendoline Hoslett (Oxford). The role of the p97 system in the repair of cytotoxic trapped PARP1.
12) 2019-2024 Pauline Lascaux (Oxford). TEX264 orchestrates selective autophagy of DNA lesions.
11) 2019-2024 Ftoon Aljarbou (Oxford). Repair of ionizing-radiation induced DNA-protein crosslinks.
Graduated PhD/DPhil or DVM students; their thesis titles and the following job destinations:
10) 2019-2023 D.Phil (Oxford) Cristiano Peron. The role of SPRTN protease in colorectal carcinoma therapy. Cristiano runs his own start-up company and is the Chief Medical Officer of Oxbridge Clinical, Boston, USA.
9) 2017-2022 D.Phil. (Oxford) Susan Kilgas. p97/VCP regulates MRE11-dependent DNA end resection and alters cellular toxicity of ionising radiation. Susan took a post-doctoral position at the Dana-Farber Cancer Institute, Harvard Medical School, USA.
8) 2017-2022 D.Phil. (Oxford) Shudong Li. Dual role of p97 in DNA damage repair. The Francis Crick Institute, London.
7) 2016-2021 D.Phil. (Oxford) Sam Hume. The role of NUCKS in DNA repair. Sam has enrolled in the postgraduate Medical School Programme at the University of Oxford.
6) 2015-2019 D.Phil. (Oxford) John Fielden. The p97 system regulates Topoisomerase 1-cleavage complex repair. John has moved to the Swiss Federal Institute of Technology (ETH-Zurich) as a post-doctoral fellow.
5) 2014-2017 D.Phil. (Oxford) Katherine Wiseman; Characterization of a new p97 adaptor in genome stability. Dr. Wiseman has since moved to Immunocore Ltd, Oxford, as a scientist.
4) 2012-2016 D.Phil. (Oxford) Swagata Halder; The role of p97 cofactors SPRTN and FAF1 in DNA replication. Dr. Halder received a prestigious long-term EMBO postdoctoral fellowship and moved to the lab of Prof. V Costanzo, IFOM, Milan, Italy.
3) 2012-2016 D.Phil. (Oxford) Judith Oehler; Orchestration of the ubiquitin-dependent DNA damage response by the p97 system. Dr. Oehler has since started her postdoctoral position in the lab of Prof. M. Whitby, Institute of Biochemistry, University of Oxford.
2) 2011-2013 D.V.M. (Zurich) Sebastian Koller; Chromatin-associated protein degradation: influence of p97/VCP on key factors in DNA damage response.
1) 2009 -2010 D.V.M. (Zurich) Matthias Bosshard; Involvement of the AAA ATPase p97/VCP in DNA metabolism. Dr. Bosshard was awarded the best DVM thesis in Switzerland for 2010 and started his PhD at the University of Zurich.