Academic Profile : Faculty

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Assoc Prof Saravana Ramasamy
Associate Professor of Metabolic Medicine, Lee Kong Chian School of Medicine
Associate Professor, Lee Kong Chian School of Medicine
Journal Articles
(Not applicable to NIE
staff as info will be
pulled from PRDS)
Rodrigues J, Wang Y-F, Hendriks M, Singh A, Dharmalingam G, Kusumbe AP, Ramasamy SK (2022) Oestrogen enforces the integrity of blood vessels in the bone during pregnancy and menopause Nat Cardiovasc Res 1:918-932.

Biswas L, Chen J, De Angelis J, Singh A, Owen-Woods C, Ding Z, Pujol JM, Zeng F, Ramasamy SK, Kusumbe AP (2023) Lymphatic vessels in bone support regeneration after injury Cell 186(2):382-397.

Romeo S, Alawi K, Rodrigues J, Singh A, Kusumbe AP & Ramasamy SK (2019) Endothelial proteolytic activity and interaction with non-resorbing osteoclasts mediate bone elongation, Nat Cell Biol. 21(4):430-441. Recommended in F1000

Chen J, Sivan U, Tan SL, Lippo L, De Angelis J, Labella R, Singh A, Chatzis A, Cheuk S, Medhghalchi M, Gil J, Hollander G, Marsden BD, Williams R, Ramasamy SK, Kusumbe AP (2021) High-resolution 3D imaging uncovers organ-specific vascular control of tissue aging Sci Adv. 3;7(6): eabd7819.

Chen J, Lippo L, Labella R, Tan SL, Marsden BD, Ramasamy SK, Kusumbe AP (2020) Single-cell resolution 3D imaging reveals dysregulation of vasculature in ageing of the endocrine system EMBO J: e105242.

Duarte D, Hawkins ED, Akinduro O, Ang H, De Filippo K, Kong IY, Haltalli M, Ruivo N, Straszkowski L, Vervoort SJ, McLean C, Weber TS, Khorshed R, Pirillo C, Wei A, Ramasamy SK, Kusumbe AP, Duffy K, Adams RH, Purton LE, Carlin LM, Lo Celso C (2018) Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML. Cell Stem Cell 4;22(1):64-77.

Singh A, Veeriah V, Xi P, Labella R, Chen J, Romeo S, Ramasamy SK & Kusumbe AP (2019) Angiocrine signals regulate quiescence and therapy resistance in bone metastasis, JCI insight 4(13): e125679.

Chen J, Hendriks M, Chatzis A, Ramasamy SK, Kusumbe AP (2020) Bone Vasculature and Bone Marrow Vascular Niches in Health and Disease. J Bone Miner Res. jbmr.4171.

Hendriks M and Ramasamy SK (2020) Blood Vessels and Vascular Niches in Bone Development and Physiological Remodelling. Front. Cell Dev. Biol. 8:602278.

Ramasamy SK Structure and Functions of Blood Vessels and Vascular Niches in Bone (2017) Stem Cells Int. 2017:5046953.

Ramasamy SK#, Kusumbe AP, Schiller M, Bixel GM, Gambrekeshvili J, Limbourg F, Adams RH# (2016) Blood flow controls bone vascular function and osteogenesis Nat commun. 7:13601 # Co-corresponding authors

Ramasamy SK*, Kusumbe AP*, Wang L, Adams RH (2014) Endothelial Notch activity promotes angiogenesis and osteogenesis in bone. Nature 507: 376-380. *Equal Contributions

Kusumbe AP*, Ramasamy SK*, Adams RH (2014) Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone. Nature 507: 323-328. *Equal Contributions

Ramasamy SK, Kusumbe AP, Itkin T, Cohen SG, Lapidot T, Adams RH (2016) Endothelial regulation of osteogenesis and haematopoiesis Annu Rev Cell Dev Biol. 32:649-675.

Kusumbe AP, Ramasamy SK, Mäe MA, Langen UH, Betsholtz C, Adams RH (2016) Age-dependent modulation of vascular niches for haematopoietic stem cells Nature 532, 380–384. Recommended in F1000

Itkin T, Cohen SG, Spencer JA, Schajnovitz A, Ramasamy SK, et al., (2016) Distinct bone marrow blood vessels differentially regulate hematopoiesis Nature 532, 323–328. Recommended in F1000

Kusumbe AP#, Ramasamy SK#, A Starsichova, Adams RH# (2015) High-resolution three-dimensional imaging of skeletal tissue with confocal microscopy. Nat. Protoc. 10: 1904-1914. Cover article # Co-corresponding authors

Bixel MG, Kusumbe AP, Ramasamy SK, Sivaraj KK, Butz S, Vestweber D, Adams RH (2017) Blood flow dynamics and HSPC homing in bone marrow microvessels in living mice. Cell Reports 18(7):1804-1816.

Ramasamy SK, Kusumbe AP, Adams RH (2015) Regulation of tissue morphogenesis by endothelial cell-derived signals. Trends Cell Biol. 25(3):148-57.

Gamrekelashvili J, Giagnorio R, Jussofie J, Soehnlein O, Duchene J, Briseño CG, Ramasamy SK, et al., (2016) Regulation of monocyte cell fate by blood vessels mediated by Notch signaling. Nat Commun. 7:12597.
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