Academic Profile : Faculty

Asst Prof Laura Nolan
Assistant Professor, School of Biological Sciences
Assistant Professor, Singapore Centre for Environmental Life Sciences Engineering
Email
Journal Articles
(Not applicable to NIE
staff as info will be
pulled from PRDS)
(Not applicable to NIE
staff as info will be
pulled from PRDS)
Micaela Mossop, Jonathan Ish-Horowicz, Dominic Hughes, Rebecca Dobra, Alessandra G. Cunanan, Mark Rosenthal, Siobhán B Carr, Newara Ramadan, Laura M. Nolan*, and Jane C. Davies* (2024) Chronicity counts: The impact of P. aeruginosa, S. aureus, and co-infection in cystic fibrosis. American Journal of Respiratory and Critical Care Medicine, Feb 29. http://doi.org10.1164/rccm.202312-2326LE.
Ronan A. Murphy, Jade Pizzato, Leah Cuthbertson, Akshay Sabnis, Andrew Edwards, Laura M. Nolan, Thomas Vorup-Jensen, Gerald Larrouy-Maumus and Jane C. Davies (2024) Antimicrobial peptide glatiramer acetate targets Pseudomonas aeruginosa lipopolysaccharides to breach membranes without altering lipopolysaccharide modification. npj Antimicrobials and Resistance, 2(4). https://doi.org/10.1038/s44259-024-00022-x.
Lynne Turnbull, Roger Leigh, Rosalia Cavaliere, Sarah R. Osvath, Laura M. Nolan, Daniel Smyth, Kristien Verhoeven, Rochard A. Chole and Cynthia B. Whitchurch (2021) Device Design Modifications Informed by In Vitro Testing of Bacterial Attachment Reduce Infection Rates of Cochlear Implants in Clinical Practice. Microorganisms, 9(9), 1809. https://doi.org/10.3390/microorganisms9091809.
Laura M. Nolan, Amy K. Cain, Thomas Clamens, R. Christopher D. Furniss, Eleni Manoli, Maria A. Sainz-Polo, Gordon Dougan, David Albesa-Jové, Julian Parkhill, Despoina A. I. Mavridou and Alain Filloux (2021) Identification of Tse8 as a Type VI secretion system toxin from Pseudomonas aeruginosa that targets the bacterial transamidosome to inhibit protein synthesis in prey cells. Nature Microbiology, 6, 1199–1210. https://doi.org/10.1038/s41564-021-00950-8.
Pappu K. Mandal, Giulia Ballerin, Laura M. Nolan, Nicola K. Petty and Cynthia B.
Whitchurch (2021) Bacteriophage infection produces membrane vesicles in Escherichia coli via both explosive cell lysis and membrane blebbing. Microbiology, 167:001021. https://doi.org/10.1099/mic.0.001021.
Amelia L. Hynen, James J. Lazenby, George M. Savva, Laura C. McCaughey, Lynne
Turnbull, Laura M. Nolan* and Cynthia B. Whitchurch* (2021) Multiple holins contribute to extracellular DNA release in Pseudomonas aeruginosa biofilms. Microbiology, 167(2):000990. https://doi.org/10.1099/mic.0.000990.
Laura M. Nolan, Lynne Turnbull, Marilyn Katrib, Sarah R. Osvath, Davide Losa, James J. Lazenby and Cynthia B. Whitchurch (2020) Pseudomonas aeruginosa is capable of natural transformation in biofilms. Microbiology, 166(10):995-1003. https://doi.org/10.1099/mic.0.000956.
Laura M. Nolan, Laura C. McCaughey, Jessica Merjane, Lynne Turnbull, Cynthia B. Whitchurch (2020) ChpC controls twitching motility-mediated expansion of Pseudomonas aeruginosa biofilms in response to serum albumin, mucin and oligopeptides. Microbiology, 166(7):669-678. https://doi.org/10.1099/mic.0.000911.
Luke P. Allsopp, Patricia Bernal, Laura M. Nolan and Alain Filloux (2020) Causalities of war: The connection between type VI secretion system and microbiota. Cellular Microbiology, 22(3):e13153. https://doi.org/10.1111/cmi.13153.
Amy K. Cain, Laura M. Nolan, Geraldine Sullivan, Cynthia B. Whitchurch, Alain Filloux and Julian Parkhill (2019) Complete genome sequence of Pseudomonas aeruginosa reference strain PAK. Microbiology Resource Announcements, 8:e00865-19. https://doi.org/10.1128/MRA.00865-19.
Thomas E. Wood, Andreas Förster, Eleni Manoli, Laura M. Nolan, Sophie A. Howard, Abderrahman Hachani, Richard Hayward, Paul S. Freemont and Alain Filloux (2019) The Pseudomonas aeruginosa T6SS delivers a periplasmic toxin disrupting bacterial cell morphology. Cell Reports, 29(1):187-201.e7. https://doi.org/10.1016/j.celrep.2019.08.094.
Laura M. Nolan, Cynthia B. Whitchurch, Lars Barquist, Marilyn Katrib, Christine J. Boinett, Matthew Mayho, David Goulding, Ian G. Charles, Alain Filloux, Julian Parkhill and Amy K. Cain (2018) A global genomic approach uncovers novel components for twitching motility-mediated biofilm expansion in Pseudomonas aeruginosa. Microbial Genomics, 4(11):e000229. https://doi.org/10.1099/mgen.0.000229.
Anne Lorenz, Mattias Preuße, Simon Bruchmann, Victor Pawar, Niels Grahl, Matthew Pils, Laura M. Nolan, Alain Filloux, Sigi Weiß and Susanne Häußler (2018) Importance of flagella mediated activation of the host immune response for the establishment of a chronic Pseudomonas aeruginosa infection type. Environmental Microbiology, 21(3):883-897. https://doi.org/10.1111/1462-2920.14468.
Luke P. Allsopp, Thomas E. Wood, Sophie A. Howard, Federica Maggiorelli, Laura M. Nolan, Sarah Wettstadt, and Alain Filloux (2017) RsmA and AmrZ orchestrate the assembly of all three type VI secretion systems in Pseudomonas aeruginosa. PNAS, 114(29):7707-7712. https://doi.org/10.1073/pnas.1700286114.
Laura M. Nolan, Rosalia Cavaliere, Lynne Turnbull, and Cynthia B. Whitchurch (2015) Extracellular ATP inhibits twitching motility-mediated biofilm expansion by Pseudomonas aeruginosa. BMC Microbiology, 15:55. https://doi.org/10.1186/s12866-015-0392-x.
Amanda Mackie, Ingrid M. Keseler, Laura M. Nolan, Peter D. Karp, Ian T. Paulsen (2013) Dead End Metabolites - Defining the Known Unknowns of the E. coli Metabolic Network. PLoS ONE, 8(9):e75210. https://doi.org/10.1371/journal.pone.0075210.
Erin S. Gloag, Lynne Turnbull, Alan Huang, Pascal Vallotton, Huabin Wang, Laura M. Nolan, Lisa Millili, Cameron Hunt, Jing Lu, Sarah R. Osvath, Leigh G. Monahan, Rosalia Cavaliere, Ian G. Charles, Matt P. Wand, Michelle L. Gee, Ranganathan Prabhakar, Cynthia B. Whitchurch (2013) Self-organization of bacterial biofilms is facilitated by extracellular DNA. PNAS, 110(28):11541-6. https://doi.org/10.1073/pnas.1218898110.
Laura M. Nolan, Scott A. Beatson, Larry Croft, Peter M. Jones, Anthony M. George, John S. Mattick, Lynne Turnbull, and Cynthia B. Whitchurch (2012) Extragenic suppressor mutations that restore twitching motility to fimL mutants of Pseudomonas aeruginosa are associated with elevated intracellular cyclic AMP levels. Microbiology Open, 1(4):490-501. https://doi.org/10.1002/mbo3.49.
Nicholas V. Coleman, Sheree Yau, Neil L. Wilson, Laura M. Nolan, Margaret D. Migocki, Mai-anh Ly, Ben Crossett and Andrew J. Holmes (2011) Untangling the multiple monooxygenases of Mycobacterium chubunese strain NBB4, a versatile hydrocarbon degrader. Environmental Microbiology Reports, 3(3):297-307. https://doi.org/10.1111/j.1758-2229.2010.00225.x.
Ingrid M. Keseler, César Bonavides-Martínez, Julio Collado-Vides, Socorro Gama-Castro, Robert P. Gunsalus, D. Aaron Johnson, Markus Krummenacker, Laura M. Nolan, Suzanne Paley, Ian T. Paulsen, Martin Peralta-Gil, Alberto Santos-Zavaleta, Alexander Glennon Shearer and Peter D. Karp (2009) Ecocyc: A comprehensive view of Escherichia coli biology. Nucleic Acids Research, 37:D464-470. https://doi.org/10.1093/nar/gkn751.
Ronan A. Murphy, Jade Pizzato, Leah Cuthbertson, Akshay Sabnis, Andrew Edwards, Laura M. Nolan, Thomas Vorup-Jensen, Gerald Larrouy-Maumus and Jane C. Davies (2024) Antimicrobial peptide glatiramer acetate targets Pseudomonas aeruginosa lipopolysaccharides to breach membranes without altering lipopolysaccharide modification. npj Antimicrobials and Resistance, 2(4). https://doi.org/10.1038/s44259-024-00022-x.
Lynne Turnbull, Roger Leigh, Rosalia Cavaliere, Sarah R. Osvath, Laura M. Nolan, Daniel Smyth, Kristien Verhoeven, Rochard A. Chole and Cynthia B. Whitchurch (2021) Device Design Modifications Informed by In Vitro Testing of Bacterial Attachment Reduce Infection Rates of Cochlear Implants in Clinical Practice. Microorganisms, 9(9), 1809. https://doi.org/10.3390/microorganisms9091809.
Laura M. Nolan, Amy K. Cain, Thomas Clamens, R. Christopher D. Furniss, Eleni Manoli, Maria A. Sainz-Polo, Gordon Dougan, David Albesa-Jové, Julian Parkhill, Despoina A. I. Mavridou and Alain Filloux (2021) Identification of Tse8 as a Type VI secretion system toxin from Pseudomonas aeruginosa that targets the bacterial transamidosome to inhibit protein synthesis in prey cells. Nature Microbiology, 6, 1199–1210. https://doi.org/10.1038/s41564-021-00950-8.
Pappu K. Mandal, Giulia Ballerin, Laura M. Nolan, Nicola K. Petty and Cynthia B.
Whitchurch (2021) Bacteriophage infection produces membrane vesicles in Escherichia coli via both explosive cell lysis and membrane blebbing. Microbiology, 167:001021. https://doi.org/10.1099/mic.0.001021.
Amelia L. Hynen, James J. Lazenby, George M. Savva, Laura C. McCaughey, Lynne
Turnbull, Laura M. Nolan* and Cynthia B. Whitchurch* (2021) Multiple holins contribute to extracellular DNA release in Pseudomonas aeruginosa biofilms. Microbiology, 167(2):000990. https://doi.org/10.1099/mic.0.000990.
Laura M. Nolan, Lynne Turnbull, Marilyn Katrib, Sarah R. Osvath, Davide Losa, James J. Lazenby and Cynthia B. Whitchurch (2020) Pseudomonas aeruginosa is capable of natural transformation in biofilms. Microbiology, 166(10):995-1003. https://doi.org/10.1099/mic.0.000956.
Laura M. Nolan, Laura C. McCaughey, Jessica Merjane, Lynne Turnbull, Cynthia B. Whitchurch (2020) ChpC controls twitching motility-mediated expansion of Pseudomonas aeruginosa biofilms in response to serum albumin, mucin and oligopeptides. Microbiology, 166(7):669-678. https://doi.org/10.1099/mic.0.000911.
Luke P. Allsopp, Patricia Bernal, Laura M. Nolan and Alain Filloux (2020) Causalities of war: The connection between type VI secretion system and microbiota. Cellular Microbiology, 22(3):e13153. https://doi.org/10.1111/cmi.13153.
Amy K. Cain, Laura M. Nolan, Geraldine Sullivan, Cynthia B. Whitchurch, Alain Filloux and Julian Parkhill (2019) Complete genome sequence of Pseudomonas aeruginosa reference strain PAK. Microbiology Resource Announcements, 8:e00865-19. https://doi.org/10.1128/MRA.00865-19.
Thomas E. Wood, Andreas Förster, Eleni Manoli, Laura M. Nolan, Sophie A. Howard, Abderrahman Hachani, Richard Hayward, Paul S. Freemont and Alain Filloux (2019) The Pseudomonas aeruginosa T6SS delivers a periplasmic toxin disrupting bacterial cell morphology. Cell Reports, 29(1):187-201.e7. https://doi.org/10.1016/j.celrep.2019.08.094.
Laura M. Nolan, Cynthia B. Whitchurch, Lars Barquist, Marilyn Katrib, Christine J. Boinett, Matthew Mayho, David Goulding, Ian G. Charles, Alain Filloux, Julian Parkhill and Amy K. Cain (2018) A global genomic approach uncovers novel components for twitching motility-mediated biofilm expansion in Pseudomonas aeruginosa. Microbial Genomics, 4(11):e000229. https://doi.org/10.1099/mgen.0.000229.
Anne Lorenz, Mattias Preuße, Simon Bruchmann, Victor Pawar, Niels Grahl, Matthew Pils, Laura M. Nolan, Alain Filloux, Sigi Weiß and Susanne Häußler (2018) Importance of flagella mediated activation of the host immune response for the establishment of a chronic Pseudomonas aeruginosa infection type. Environmental Microbiology, 21(3):883-897. https://doi.org/10.1111/1462-2920.14468.
Luke P. Allsopp, Thomas E. Wood, Sophie A. Howard, Federica Maggiorelli, Laura M. Nolan, Sarah Wettstadt, and Alain Filloux (2017) RsmA and AmrZ orchestrate the assembly of all three type VI secretion systems in Pseudomonas aeruginosa. PNAS, 114(29):7707-7712. https://doi.org/10.1073/pnas.1700286114.
Laura M. Nolan, Rosalia Cavaliere, Lynne Turnbull, and Cynthia B. Whitchurch (2015) Extracellular ATP inhibits twitching motility-mediated biofilm expansion by Pseudomonas aeruginosa. BMC Microbiology, 15:55. https://doi.org/10.1186/s12866-015-0392-x.
Amanda Mackie, Ingrid M. Keseler, Laura M. Nolan, Peter D. Karp, Ian T. Paulsen (2013) Dead End Metabolites - Defining the Known Unknowns of the E. coli Metabolic Network. PLoS ONE, 8(9):e75210. https://doi.org/10.1371/journal.pone.0075210.
Erin S. Gloag, Lynne Turnbull, Alan Huang, Pascal Vallotton, Huabin Wang, Laura M. Nolan, Lisa Millili, Cameron Hunt, Jing Lu, Sarah R. Osvath, Leigh G. Monahan, Rosalia Cavaliere, Ian G. Charles, Matt P. Wand, Michelle L. Gee, Ranganathan Prabhakar, Cynthia B. Whitchurch (2013) Self-organization of bacterial biofilms is facilitated by extracellular DNA. PNAS, 110(28):11541-6. https://doi.org/10.1073/pnas.1218898110.
Laura M. Nolan, Scott A. Beatson, Larry Croft, Peter M. Jones, Anthony M. George, John S. Mattick, Lynne Turnbull, and Cynthia B. Whitchurch (2012) Extragenic suppressor mutations that restore twitching motility to fimL mutants of Pseudomonas aeruginosa are associated with elevated intracellular cyclic AMP levels. Microbiology Open, 1(4):490-501. https://doi.org/10.1002/mbo3.49.
Nicholas V. Coleman, Sheree Yau, Neil L. Wilson, Laura M. Nolan, Margaret D. Migocki, Mai-anh Ly, Ben Crossett and Andrew J. Holmes (2011) Untangling the multiple monooxygenases of Mycobacterium chubunese strain NBB4, a versatile hydrocarbon degrader. Environmental Microbiology Reports, 3(3):297-307. https://doi.org/10.1111/j.1758-2229.2010.00225.x.
Ingrid M. Keseler, César Bonavides-Martínez, Julio Collado-Vides, Socorro Gama-Castro, Robert P. Gunsalus, D. Aaron Johnson, Markus Krummenacker, Laura M. Nolan, Suzanne Paley, Ian T. Paulsen, Martin Peralta-Gil, Alberto Santos-Zavaleta, Alexander Glennon Shearer and Peter D. Karp (2009) Ecocyc: A comprehensive view of Escherichia coli biology. Nucleic Acids Research, 37:D464-470. https://doi.org/10.1093/nar/gkn751.
Book Chapters
(Not applicable to NIE
staff as info will be
pulled from PRDS)
(Not applicable to NIE
staff as info will be
pulled from PRDS)
Laura M. Nolan* and Luke P. Allsopp* (2022) Antimicrobial weapons of Pseudomonas aeruginosa. In: Ramos J. L., Filloux A. M. (eds) Pseudomonas aeruginosa: biology, pathogenesis and control strategies. Advances in Experimental Medicine and Biology, 1386:223-256. *Equal author contribution. https://doi.org/10.1007/978-3-031-08491-1_8.
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