Academic Profile : Faculty

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Asst Prof Dan He
Assistant Professor, School of Chemistry, Chemical Engineering and Biotechnology
Journal Articles
(Not applicable to NIE
staff as info will be
pulled from PRDS)
Xiao, T.#; He, D.#; Liu, D.; Jia, S.; Chen, Q.; Silverman, D.; Maitra, N.; Huang, A. Y.; Nguyen, T. T.; Rao, G.; Tillage, R.; Deng, K.; Weinshenker, D.; Britt, R. D.; Kelly, M. J. S.; Dan, Y.; Chang, C. J., RAD23B acquires a copper metalloadapter function during evolution to augment metabolism and regulate genome integrity. Under review. (#co-first authors)

He, D.; Feng, H.; Sundberg, B.; Yang, J.; Powers, J.; Christian, A. H.; Wilkinson, J. E.; Monnin, C.; Avizonis, D.; Thomas, C. J.; Friedman, R. A.; Kluger, M. D.; Hollingsworth, M. A.; Grandgenett, P. M.; Klute, K. A.; Toste, F. D.; Chang, C. J.; Chio, I. I. C., Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis. Mol Cell 2022, 82 (16), 3045-3060 e11.

He, D.; Zhang, M.; Liu, S.; Xie, X.; Chen, P. R., Protease-Mediated Protein Quality Control for Bacterial Acid Resistance. Cell Chem Biol 2019, 26 (1), 144-150 e3.

He, D.; Xie, X.; Yang, F.; Zhang, H.; Su, H.; Ge, Y.; Song, H.; Chen, P. R., Quantitative and Comparative Profiling of Protease Substrates through a Genetically Encoded Multifunctional Photocrosslinker. Angew Chem Int Ed Engl 2017, 56 (46), 14521-14525.

Zhang, S.#; He, D.#; Yang, Y.; Lin, S.; Zhang, M.; Dai, S.; Chen, P. R., Comparative proteomics reveal distinct chaperone-client interactions in supporting bacterial acid resistance. Proc Natl Acad Sci U S A 2016, 113 (39), 10872-7. (#co-first authors)

Xie, X.; Moon, P. J.; Crossley, S. W. M.; Bischoff, A. J.; He, D.; Li, G.; Dao, N.; Gonzalez-Valero, A.; Reeves, A. G.; McKenna, J. M.; Elledge, S. K.; Wells, J. A.; Toste, F. D.; Chang, C. J., Oxidative cyclization reagents reveal tryptophan cation-pi interactions. Nature 2024, 627 (8004), 680-687.

Gonzalez-Valero, A.; Reeves, A. G.; Page, A. C. S.; Moon, P. J.; Miller, E.; Coulonval, K.; Crossley, S. W. M.; Xie, X.; He, D.; Musacchio, P. Z.; Christian, A. H.; McKenna, J. M.; Lewis, R. A.; Fang, E.; Dovala, D.; Lu, Y.; McGregor, L. M.; Schirle, M.; Tallarico, J. A.; Roger, P. P.; Toste, F. D.; Chang, C. J., An Activity-Based Oxaziridine Platform for Identifying and Developing Covalent Ligands for Functional Allosteric Methionine Sites: Redox-Dependent Inhibition of Cyclin-Dependent Kinase 4. J Am Chem Soc 2022, 144 (50), 22890-22901.

Toh, J. D. W.; Crossley, S. W. M.; Bruemmer, K. J.; Ge, E. J.; He, D.; Iovan, D. A.; Chang, C. J., Distinct RNA N-demethylation pathways catalyzed by nonheme iron ALKBH5 and FTO enzymes enable regulation of formaldehyde release rates. Proc Natl Acad Sci U S A 2020, 117 (41), 25284-25292.

Jia, S.; He, D.; Chang, C. J., Bioinspired Thiophosphorodichloridate Reagents for Chemoselective Histidine Bioconjugation. J Am Chem Soc 2019, 141 (18), 7294-7301.

Yang, Y.; Song, H.;He, D.; Zhang, S.; Dai, S.; Lin, S.; Meng, R.; Wang, C.; Chen, P. R., Genetically encoded protein photocrosslinker with a transferable mass spectrometry-identifiable label. Nat Commun 2016, 7, 12299.

Zhang, S.; He, D.; Lin, Z.; Yang, Y.; Song, H.; Chen, P. R., Conditional Chaperone-Client Interactions Revealed by Genetically Encoded Photo-cross-linkers. Acc Chem Res 2017, 50 (5), 1184-1192.

Yang, Y.; Song, H.; He, D.; Zhang, S.; Dai, S.; Lin, S.; Meng, R.; Wang, C.; Chen, P. R., Genetically encoded protein photocrosslinker with a transferable mass spectrometry-identifiable label. Nat. Commun. 7, 12299, doi:10.1038/ncomms12299 (2016). (IF = 17.69)

Lin, S.; He, D.; Long, T.; Zhang, S.; Meng, R.; Chen, P. R., Genetically encoded cleavable protein photo-cross-linker. J Am Chem Soc 2014, 136 (34), 11860-3.