Academic Profile : Faculty
Asst Prof Dan He
Assistant Professor, School of Chemistry, Chemical Engineering and Biotechnology
Email
Journal Articles
(Not applicable to NIE
staff as info will be
pulled from PRDS)
(Not applicable to NIE
staff as info will be
pulled from PRDS)
Xiao, T.#; He, D.#; Liu, D.; Jia, S.; Chen, Q.; Silverman, D.; Maitra, N.; Huang, A. Y.; Nguyen, T. T.; Rao, G.; Tillage, R.; Deng, K.; Weinshenker, D.; Britt, R. D.; Kelly, M. J. S.; Dan, Y.; Chang, C. J., RAD23B acquires a copper metalloadapter function during evolution to augment metabolism and regulate genome integrity. Under review. (#co-first authors)
He, D.; Feng, H.; Sundberg, B.; Yang, J.; Powers, J.; Christian, A. H.; Wilkinson, J. E.; Monnin, C.; Avizonis, D.; Thomas, C. J.; Friedman, R. A.; Kluger, M. D.; Hollingsworth, M. A.; Grandgenett, P. M.; Klute, K. A.; Toste, F. D.; Chang, C. J.; Chio, I. I. C., Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis. Mol Cell 2022, 82 (16), 3045-3060 e11.
He, D.; Zhang, M.; Liu, S.; Xie, X.; Chen, P. R., Protease-Mediated Protein Quality Control for Bacterial Acid Resistance. Cell Chem Biol 2019, 26 (1), 144-150 e3.
He, D.; Xie, X.; Yang, F.; Zhang, H.; Su, H.; Ge, Y.; Song, H.; Chen, P. R., Quantitative and Comparative Profiling of Protease Substrates through a Genetically Encoded Multifunctional Photocrosslinker. Angew Chem Int Ed Engl 2017, 56 (46), 14521-14525.
Zhang, S.#; He, D.#; Yang, Y.; Lin, S.; Zhang, M.; Dai, S.; Chen, P. R., Comparative proteomics reveal distinct chaperone-client interactions in supporting bacterial acid resistance. Proc Natl Acad Sci U S A 2016, 113 (39), 10872-7. (#co-first authors)
Xie, X.; Moon, P. J.; Crossley, S. W. M.; Bischoff, A. J.; He, D.; Li, G.; Dao, N.; Gonzalez-Valero, A.; Reeves, A. G.; McKenna, J. M.; Elledge, S. K.; Wells, J. A.; Toste, F. D.; Chang, C. J., Oxidative cyclization reagents reveal tryptophan cation-pi interactions. Nature 2024, 627 (8004), 680-687.
Gonzalez-Valero, A.; Reeves, A. G.; Page, A. C. S.; Moon, P. J.; Miller, E.; Coulonval, K.; Crossley, S. W. M.; Xie, X.; He, D.; Musacchio, P. Z.; Christian, A. H.; McKenna, J. M.; Lewis, R. A.; Fang, E.; Dovala, D.; Lu, Y.; McGregor, L. M.; Schirle, M.; Tallarico, J. A.; Roger, P. P.; Toste, F. D.; Chang, C. J., An Activity-Based Oxaziridine Platform for Identifying and Developing Covalent Ligands for Functional Allosteric Methionine Sites: Redox-Dependent Inhibition of Cyclin-Dependent Kinase 4. J Am Chem Soc 2022, 144 (50), 22890-22901.
Toh, J. D. W.; Crossley, S. W. M.; Bruemmer, K. J.; Ge, E. J.; He, D.; Iovan, D. A.; Chang, C. J., Distinct RNA N-demethylation pathways catalyzed by nonheme iron ALKBH5 and FTO enzymes enable regulation of formaldehyde release rates. Proc Natl Acad Sci U S A 2020, 117 (41), 25284-25292.
Jia, S.; He, D.; Chang, C. J., Bioinspired Thiophosphorodichloridate Reagents for Chemoselective Histidine Bioconjugation. J Am Chem Soc 2019, 141 (18), 7294-7301.
Yang, Y.; Song, H.;He, D.; Zhang, S.; Dai, S.; Lin, S.; Meng, R.; Wang, C.; Chen, P. R., Genetically encoded protein photocrosslinker with a transferable mass spectrometry-identifiable label. Nat Commun 2016, 7, 12299.
Zhang, S.; He, D.; Lin, Z.; Yang, Y.; Song, H.; Chen, P. R., Conditional Chaperone-Client Interactions Revealed by Genetically Encoded Photo-cross-linkers. Acc Chem Res 2017, 50 (5), 1184-1192.
Yang, Y.; Song, H.; He, D.; Zhang, S.; Dai, S.; Lin, S.; Meng, R.; Wang, C.; Chen, P. R., Genetically encoded protein photocrosslinker with a transferable mass spectrometry-identifiable label. Nat. Commun. 7, 12299, doi:10.1038/ncomms12299 (2016). (IF = 17.69)
Lin, S.; He, D.; Long, T.; Zhang, S.; Meng, R.; Chen, P. R., Genetically encoded cleavable protein photo-cross-linker. J Am Chem Soc 2014, 136 (34), 11860-3.
He, D.; Feng, H.; Sundberg, B.; Yang, J.; Powers, J.; Christian, A. H.; Wilkinson, J. E.; Monnin, C.; Avizonis, D.; Thomas, C. J.; Friedman, R. A.; Kluger, M. D.; Hollingsworth, M. A.; Grandgenett, P. M.; Klute, K. A.; Toste, F. D.; Chang, C. J.; Chio, I. I. C., Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis. Mol Cell 2022, 82 (16), 3045-3060 e11.
He, D.; Zhang, M.; Liu, S.; Xie, X.; Chen, P. R., Protease-Mediated Protein Quality Control for Bacterial Acid Resistance. Cell Chem Biol 2019, 26 (1), 144-150 e3.
He, D.; Xie, X.; Yang, F.; Zhang, H.; Su, H.; Ge, Y.; Song, H.; Chen, P. R., Quantitative and Comparative Profiling of Protease Substrates through a Genetically Encoded Multifunctional Photocrosslinker. Angew Chem Int Ed Engl 2017, 56 (46), 14521-14525.
Zhang, S.#; He, D.#; Yang, Y.; Lin, S.; Zhang, M.; Dai, S.; Chen, P. R., Comparative proteomics reveal distinct chaperone-client interactions in supporting bacterial acid resistance. Proc Natl Acad Sci U S A 2016, 113 (39), 10872-7. (#co-first authors)
Xie, X.; Moon, P. J.; Crossley, S. W. M.; Bischoff, A. J.; He, D.; Li, G.; Dao, N.; Gonzalez-Valero, A.; Reeves, A. G.; McKenna, J. M.; Elledge, S. K.; Wells, J. A.; Toste, F. D.; Chang, C. J., Oxidative cyclization reagents reveal tryptophan cation-pi interactions. Nature 2024, 627 (8004), 680-687.
Gonzalez-Valero, A.; Reeves, A. G.; Page, A. C. S.; Moon, P. J.; Miller, E.; Coulonval, K.; Crossley, S. W. M.; Xie, X.; He, D.; Musacchio, P. Z.; Christian, A. H.; McKenna, J. M.; Lewis, R. A.; Fang, E.; Dovala, D.; Lu, Y.; McGregor, L. M.; Schirle, M.; Tallarico, J. A.; Roger, P. P.; Toste, F. D.; Chang, C. J., An Activity-Based Oxaziridine Platform for Identifying and Developing Covalent Ligands for Functional Allosteric Methionine Sites: Redox-Dependent Inhibition of Cyclin-Dependent Kinase 4. J Am Chem Soc 2022, 144 (50), 22890-22901.
Toh, J. D. W.; Crossley, S. W. M.; Bruemmer, K. J.; Ge, E. J.; He, D.; Iovan, D. A.; Chang, C. J., Distinct RNA N-demethylation pathways catalyzed by nonheme iron ALKBH5 and FTO enzymes enable regulation of formaldehyde release rates. Proc Natl Acad Sci U S A 2020, 117 (41), 25284-25292.
Jia, S.; He, D.; Chang, C. J., Bioinspired Thiophosphorodichloridate Reagents for Chemoselective Histidine Bioconjugation. J Am Chem Soc 2019, 141 (18), 7294-7301.
Yang, Y.; Song, H.;He, D.; Zhang, S.; Dai, S.; Lin, S.; Meng, R.; Wang, C.; Chen, P. R., Genetically encoded protein photocrosslinker with a transferable mass spectrometry-identifiable label. Nat Commun 2016, 7, 12299.
Zhang, S.; He, D.; Lin, Z.; Yang, Y.; Song, H.; Chen, P. R., Conditional Chaperone-Client Interactions Revealed by Genetically Encoded Photo-cross-linkers. Acc Chem Res 2017, 50 (5), 1184-1192.
Yang, Y.; Song, H.; He, D.; Zhang, S.; Dai, S.; Lin, S.; Meng, R.; Wang, C.; Chen, P. R., Genetically encoded protein photocrosslinker with a transferable mass spectrometry-identifiable label. Nat. Commun. 7, 12299, doi:10.1038/ncomms12299 (2016). (IF = 17.69)
Lin, S.; He, D.; Long, T.; Zhang, S.; Meng, R.; Chen, P. R., Genetically encoded cleavable protein photo-cross-linker. J Am Chem Soc 2014, 136 (34), 11860-3.