Academic Profile : Faculty
Assoc Prof Anjali Parmanand Kusumbe
Associate Professor of Stem Cell Biology and Regenerative Medicine, Lee Kong Chian School of Medicine
Associate Professor, Lee Kong Chian School of Medicine
Journal Articles
(Not applicable to NIE
staff as info will be
pulled from PRDS)
(Not applicable to NIE
staff as info will be
pulled from PRDS)
Kusumbe, A. (2023). Cell scientist to watch – Anjali Kusumbe. J Cell Sci 136. 10.1242/JCS.261544/328433.
Biswas, L.*, Chen, J.*, De Angelis.*, J., Singh, A.*, Owen-Woods, C., Ding, Z., Pujol, J.M., Kumar, N., … Kusumbe, A. (2023). Lymphatic vessels in bone support regeneration after injury. Cell 186, 382-397.e24. 10.1016/J.CELL.2022.12.031. * co-first authors (listed in Alphabetical Order)
Grockowiak, E., Korn, C., Rak, J., Lysenko, V., Hallou, A., Panvini, F.M., Williams, M., Fielding, C., Fang, Z., Khatib-Massalha, E., et al. (2023). Different niches for stem cells carrying the same oncogenic driver affect pathogenesis and therapy response in myeloproliferative neoplasms. Nat Cancer 4, 1193–1209. 10.1038/S43018-023-00607-X.
Xu, Z., Kusumbe, A.P., Cai, H., Wan, Q., and Chen, J. (2023). Type H blood vessels in coupling angiogenesis-osteogenesis and its application in bone tissue engineering. J Biomed Mater Res B Appl Biomater 111, 1434–1446. 10.1002/JBM.B.35243.
Hadjihambi, A., Konstantinou, C., Klohs, J., Monsorno, K., Le Guennec, A., Donnelly, C., Cox, I.J., Kusumbe, A., Hosford, P.S., Soffientini, U., et al. (2023). Partial MCT1 invalidation protects against diet-induced non-alcoholic fatty liver disease and the associated brain dysfunction. J Hepatol 78, 180–190. 10.1016/J.JHEP.2022.08.008.
Rodrigues, J., Wang, Y.F., Singh, A., Hendriks, M., Dharmalingam, G., Cohen-Solal, M., Kusumbe, A.P., and Ramasamy, S.K. (2022). Oestrogen enforces the integrity of blood vessels in the bone during pregnancy and menopause. Nature cardiovascular research 1, 918. 10.1038/s44161-022-00139-0.
Antanaviciute, A., Kusumbe, A., and Simmons, A. (2022). Lymphatic endothelia stakeout cryptic stem cells. Cell Stem Cell 29, 1292–1293. 10.1016/J.STEM.2022.08.006.
Dzamukova, M., Brunner, T.M., Miotla-Zarebska, J., Heinrich, F., Brylka, L., Mashreghi, M.F., Kusumbe, A., Kühn, R., Schinke, T., Vincent, T.L., et al. (2022). Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth. Nat Commun 13. 10.1038/S41467-022-30618-8.
Owen-Woods, C., and Kusumbe, A. (2022). Fundamentals of bone vasculature: Specialization, interactions and functions. Semin Cell Dev Biol 123, 36–47. 10.1016/J.SEMCDB.2021.06.025.
Kumar, N., Saraber, P., Ding, Z., and Kusumbe, A.P. (2021). Diversity of Vascular Niches in Bones and Joints During Homeostasis, Ageing, and Diseases. Front Immunol 12. 10.3389/FIMMU.2021.798211.
Stucker, S., De Angelis, J., and Kusumbe, A.P. (2021). Heterogeneity and Dynamics of Vasculature in the Endocrine System During Aging and Disease. Front Physiol 12. 10.3389/FPHYS.2021.624928.
Chen, J., Sivan, U., Tan, S.L., Lippo, L., de Angelis, J., Labella, R., Singh, A., Chatzis, A., Cheuk, S., Medhghalchi, M., et al. (2021). High-resolution 3D imaging uncovers organ-specific vascular control of tissue aging. Sci Adv 7. 10.1126/SCIADV.ABD7819.
Chen, J., Lippo, L., Labella, R., Tan, S.L., Marsden, B.D., Dustin, M.L., Ramasamy, S.K., and Kusumbe, A.P. (2021). Decreased blood vessel density and endothelial cell subset dynamics during ageing of the endocrine system. EMBO J 40, e105242. 10.15252/EMBJ.2020105242.
Biswas, L., Chen, J., Angelis, J. De, Chatzis, A., Nanchahal, J., Dustin, M.L., Ramasamy, S.K., and Kusumbe, A.P. (2021). SUMIC: A Simple Ultrafast Multicolor Immunolabelling and Clearing Approach for Whole-Organ and Large Tissue 3D Imaging. bioRxiv, 2021.01.20.427385. 10.1101/2021.01.20.427385.
Stucker, S., Chen, J., Watt, F.E., and Kusumbe, A.P. (2020). Bone Angiogenesis and Vascular Niche Remodeling in Stress, Aging, and Diseases. Front Cell Dev Biol 8. 10.3389/FCELL.2020.602269.
Chen, J., Hendriks, M., Chatzis, A., Ramasamy, S.K., and Kusumbe, A.P. (2020). Bone Vasculature and Bone Marrow Vascular Niches in Health and Disease. J Bone Miner Res 35, 2103–2120. 10.1002/JBMR.4171.
Sivan, U., De Angelis, J., and Kusumbe, A.P. (2019). Role of angiocrine signals in bone development, homeostasis and disease. Open Biol 9. 10.1098/RSOB.190144.
Singh, A., Veeriah, V., Xi, P., Labella, R., Chen, J., Romeo, S.G., Ramasamy, S.K., and Kusumbe, A.P. (2019). Angiocrine signals regulate quiescence and therapy resistance in bone metastasis. JCI Insight 4. 10.1172/JCI.INSIGHT.125679.
Romeo, S.G., Alawi, K.M., Rodrigues, J., Singh, A., Kusumbe, A.P., and Ramasamy, S.K. (2019). Endothelial proteolytic activity and interaction with non-resorbing osteoclasts mediate bone elongation. Nature Cell Biology 2019 21:4 21, 430–441. 10.1038/s41556-019-0304-7.
For full list of publications please check this link
Biswas, L.*, Chen, J.*, De Angelis.*, J., Singh, A.*, Owen-Woods, C., Ding, Z., Pujol, J.M., Kumar, N., … Kusumbe, A. (2023). Lymphatic vessels in bone support regeneration after injury. Cell 186, 382-397.e24. 10.1016/J.CELL.2022.12.031. * co-first authors (listed in Alphabetical Order)
Grockowiak, E., Korn, C., Rak, J., Lysenko, V., Hallou, A., Panvini, F.M., Williams, M., Fielding, C., Fang, Z., Khatib-Massalha, E., et al. (2023). Different niches for stem cells carrying the same oncogenic driver affect pathogenesis and therapy response in myeloproliferative neoplasms. Nat Cancer 4, 1193–1209. 10.1038/S43018-023-00607-X.
Xu, Z., Kusumbe, A.P., Cai, H., Wan, Q., and Chen, J. (2023). Type H blood vessels in coupling angiogenesis-osteogenesis and its application in bone tissue engineering. J Biomed Mater Res B Appl Biomater 111, 1434–1446. 10.1002/JBM.B.35243.
Hadjihambi, A., Konstantinou, C., Klohs, J., Monsorno, K., Le Guennec, A., Donnelly, C., Cox, I.J., Kusumbe, A., Hosford, P.S., Soffientini, U., et al. (2023). Partial MCT1 invalidation protects against diet-induced non-alcoholic fatty liver disease and the associated brain dysfunction. J Hepatol 78, 180–190. 10.1016/J.JHEP.2022.08.008.
Rodrigues, J., Wang, Y.F., Singh, A., Hendriks, M., Dharmalingam, G., Cohen-Solal, M., Kusumbe, A.P., and Ramasamy, S.K. (2022). Oestrogen enforces the integrity of blood vessels in the bone during pregnancy and menopause. Nature cardiovascular research 1, 918. 10.1038/s44161-022-00139-0.
Antanaviciute, A., Kusumbe, A., and Simmons, A. (2022). Lymphatic endothelia stakeout cryptic stem cells. Cell Stem Cell 29, 1292–1293. 10.1016/J.STEM.2022.08.006.
Dzamukova, M., Brunner, T.M., Miotla-Zarebska, J., Heinrich, F., Brylka, L., Mashreghi, M.F., Kusumbe, A., Kühn, R., Schinke, T., Vincent, T.L., et al. (2022). Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth. Nat Commun 13. 10.1038/S41467-022-30618-8.
Owen-Woods, C., and Kusumbe, A. (2022). Fundamentals of bone vasculature: Specialization, interactions and functions. Semin Cell Dev Biol 123, 36–47. 10.1016/J.SEMCDB.2021.06.025.
Kumar, N., Saraber, P., Ding, Z., and Kusumbe, A.P. (2021). Diversity of Vascular Niches in Bones and Joints During Homeostasis, Ageing, and Diseases. Front Immunol 12. 10.3389/FIMMU.2021.798211.
Stucker, S., De Angelis, J., and Kusumbe, A.P. (2021). Heterogeneity and Dynamics of Vasculature in the Endocrine System During Aging and Disease. Front Physiol 12. 10.3389/FPHYS.2021.624928.
Chen, J., Sivan, U., Tan, S.L., Lippo, L., de Angelis, J., Labella, R., Singh, A., Chatzis, A., Cheuk, S., Medhghalchi, M., et al. (2021). High-resolution 3D imaging uncovers organ-specific vascular control of tissue aging. Sci Adv 7. 10.1126/SCIADV.ABD7819.
Chen, J., Lippo, L., Labella, R., Tan, S.L., Marsden, B.D., Dustin, M.L., Ramasamy, S.K., and Kusumbe, A.P. (2021). Decreased blood vessel density and endothelial cell subset dynamics during ageing of the endocrine system. EMBO J 40, e105242. 10.15252/EMBJ.2020105242.
Biswas, L., Chen, J., Angelis, J. De, Chatzis, A., Nanchahal, J., Dustin, M.L., Ramasamy, S.K., and Kusumbe, A.P. (2021). SUMIC: A Simple Ultrafast Multicolor Immunolabelling and Clearing Approach for Whole-Organ and Large Tissue 3D Imaging. bioRxiv, 2021.01.20.427385. 10.1101/2021.01.20.427385.
Stucker, S., Chen, J., Watt, F.E., and Kusumbe, A.P. (2020). Bone Angiogenesis and Vascular Niche Remodeling in Stress, Aging, and Diseases. Front Cell Dev Biol 8. 10.3389/FCELL.2020.602269.
Chen, J., Hendriks, M., Chatzis, A., Ramasamy, S.K., and Kusumbe, A.P. (2020). Bone Vasculature and Bone Marrow Vascular Niches in Health and Disease. J Bone Miner Res 35, 2103–2120. 10.1002/JBMR.4171.
Sivan, U., De Angelis, J., and Kusumbe, A.P. (2019). Role of angiocrine signals in bone development, homeostasis and disease. Open Biol 9. 10.1098/RSOB.190144.
Singh, A., Veeriah, V., Xi, P., Labella, R., Chen, J., Romeo, S.G., Ramasamy, S.K., and Kusumbe, A.P. (2019). Angiocrine signals regulate quiescence and therapy resistance in bone metastasis. JCI Insight 4. 10.1172/JCI.INSIGHT.125679.
Romeo, S.G., Alawi, K.M., Rodrigues, J., Singh, A., Kusumbe, A.P., and Ramasamy, S.K. (2019). Endothelial proteolytic activity and interaction with non-resorbing osteoclasts mediate bone elongation. Nature Cell Biology 2019 21:4 21, 430–441. 10.1038/s41556-019-0304-7.
For full list of publications please check this link