Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/96619
Title: Inherently electroactive graphene oxide nanoplatelets as labels for single nucleotide polymorphism detection
Authors: Bonanni, Alessandra
Chua, Chun Kiang
Zhao, Guanjia
Sofer, Zdeněk
Pumera, Martin
Issue Date: 2012
Source: Bonanni, A., Chua, C. K., Zhao, G., Sofer, Z., & Pumera, M. (2012). Inherently Electroactive Graphene Oxide Nanoplatelets As Labels for Single Nucleotide Polymorphism Detection. ACS Nano, 6(10), 8546-8551.
Series/Report no.: ACS nano
Abstract: Graphene materials are being widely used in electrochemistry due to their versatility and excellent properties as platforms for biosensing. However, no records show the use of inherent redox properties of graphene oxide as a label for detection. Here for the first time we used graphene oxide nanoplatelets (GONPs) as electroactive labels for DNA analysis. The working signal comes from the reduction of the oxygen-containing groups present on the surface of GONPs. The different ability of the graphene oxide nanoplatelets to conjugate to DNA hybrids obtained with complementary, noncomplementary, and one-mismatch sequences allows the discrimination of single-nucleotide polymorphism correlated with Alzheimer’s disease. We believe that our findings are very important to open a new route in the use of graphene oxide in electrochemistry.
URI: https://hdl.handle.net/10356/96619
http://hdl.handle.net/10220/10300
ISSN: 1936-0851
DOI: http://dx.doi.org/10.1021/nn301359y
Rights: © 2012 American Chemical Society.
metadata.item.grantfulltext: none
metadata.item.fulltext: No Fulltext
Appears in Collections:SPMS Journal Articles

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