Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/97102
Title: Creating a living hyaline cartilage graft free from non-cartilaginous constituents : an intermediate role of a biomaterial scaffold
Authors: Su, Kai
Lau, Ting Ting
Leong, Wenyan
Gong, Yihong
Wang, Dong-An
Issue Date: 2012
Source: Su, K., Lau, T. T., Leong, W., Gong, Y., & Wang, D.-A. (2012). Creating a Living Hyaline Cartilage Graft Free from Non-Cartilaginous Constituents: An Intermediate Role of a Biomaterial Scaffold. Advanced Functional Materials, 22(5), 972-978.
Series/Report no.: Advanced functional materials
Abstract: A novel living hyaline cartilage graft (LhCG) with controllable dimensions and free of non-cartilaginous constituents for articular regeneration is developed. As a living graft for regenerative medicine, LhCG is purely living tissue based and truly scaffold-free. The process of neotissue formation in LhCG is mediated by an interim biomaterial-based novel scaffolding system. This design highlights a philosophy of using biomaterials in engineered regenerative medicine as a transient guiding facility rather than a permanent part of substitute. The fabrication is designed and practiced in a continuous and integrated process, which attributes to its simplicity in operation. Because of the intrinsic non-cell-adhesive property of hydrogel scaffolds, articular chondrocytes’ phenotype is always preserved throughout the whole procedure, which has been tested and approved both in vitro and in vivo. In situ grafting trials in a rabbit model showcase high success rates in both cartilage repair and graft-host integration. Beyond cartilage repair, this LhCG model may provide a living-tissue-based open platform or niche for multi-tissue regenerations.
URI: https://hdl.handle.net/10356/97102
http://hdl.handle.net/10220/10432
ISSN: 1616-3028
DOI: http://dx.doi.org/10.1002/adfm.201102884
Rights: © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCBE Journal Articles

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