Cationic peptidopolysaccharides show excellent broad-spectrum antimicrobial activities and high selectivity
Poon, Yin Fun
Hammond, Paula T.
Chan-Park, Mary B.
Date of Issue2012
School of Chemical and Biomedical Engineering
Facilely synthesized cationic peptidopolysaccharides, which have a bacterial peptidoglycan-mimetic structure, show outstanding broad-spectrum activities against clinically significant bacteria and fungi and low mammalian cytotoxicity. Their structural affinity with microbial cell-wall constituents promotes penetration to reach the cytoplasmic membrane resulting in excellent antimicrobial activity and high selectivity.
© 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.