Please use this identifier to cite or link to this item:
https://hdl.handle.net/10356/97323
Title: | Fabrication of quercetin nanoparticles by anti-solvent precipitation method for enhanced dissolution | Authors: | Judeh, Zaher M. A. Kakran, Mitali Sahoo, Nanda Gopal Li, Lin |
Issue Date: | 2011 | Source: | Kakran, M., Sahoo, N. G., Li, L., & Judeh, Z. M. A. (2012). Fabrication of quercetin nanoparticles by anti-solvent precipitation method for enhanced dissolution. Powder technology, 223, 59-64. | Series/Report no.: | Powder technology | Abstract: | The aim of this study was to enhance the dissolution rate of a poorly water-soluble drug quercetin by fabricating its nanoparticles with anti-solvent precipitation using the syringe pump and to investigate the effect of drug concentration, solvent to anti-solvent (S/AS) ratio, stirring speed and flow rate on the particle size. Characterization of the original quercetin powder and nanoparticles made by syringe pump was carried out by the scanning electron microscopy (SEM), differential scanning calorimetry (DSC), X-ray diffraction (XRD) and dissolution tester. The results indicated that decreasing the drug concentration, increasing the stirring speed, flow rate and the S/AS volume ratio favoured the reduction in the particle diameter to ∼ 170 nm. Percent dissolution efficiency (%DE); relative dissolution (RD); mean dissolution time (MDT); difference factor (f1) and similarity factor (f2) were calculated for the statistical analysis. The dissolution of the drug nanoparticles was significantly higher compared with the pure drug in simulated intestinal fluid (SIF, pH 6.8). | URI: | https://hdl.handle.net/10356/97323 http://hdl.handle.net/10220/10553 |
ISSN: | 0032-5910 | DOI: | 10.1016/j.powtec.2011.08.021 | Schools: | School of Chemical and Biomedical Engineering School of Mechanical and Aerospace Engineering |
Rights: | © 2011 Elsevier B.V. | Fulltext Permission: | none | Fulltext Availability: | No Fulltext |
Appears in Collections: | MAE Journal Articles SCBE Journal Articles |
SCOPUSTM
Citations
5
100
Updated on Feb 11, 2025
Web of ScienceTM
Citations
5
72
Updated on Oct 26, 2023
Page view(s) 1
1,527
Updated on Feb 16, 2025
Google ScholarTM
Check
Altmetric
Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.