dc.contributor.authorYang, Renliang.
dc.contributor.authorHou, Wen.
dc.contributor.authorZhang, Xiaohong.
dc.contributor.authorLiu, Chuan-Fa
dc.date.accessioned2013-06-25T02:18:11Z
dc.date.available2013-06-25T02:18:11Z
dc.date.copyright2011en_US
dc.date.issued2011
dc.identifier.citationYang, R., Hou, W., Zhang, X., & Liu, C. F. (2012). N-to-C sequential ligation using peptidyl N,N-Bis(2-mercaptoethyl)amide building blocks. Organic letters, 14(1), 374-377.en_US
dc.identifier.issn1523-7060en_US
dc.identifier.urihttp://hdl.handle.net/10220/10577
dc.description.abstractA novel N- to C-terminus sequential chemical ligation approach has been developed for protein synthesis. Key to this strategy is the relative stability of the N,N-bis(2-mercaptoethyl)amide (BMEA) to the conventional conditions of native chemical ligation. We have also found a new thiol additive for the BMEA-mediated ligation reaction. The usefulness of this approach was demonstrated in the syntheses of a medium-sized peptide and ubiquitin.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesOrganic lettersen_US
dc.rights© 2011 American Chemical Society.en_US
dc.subjectDRNTU::Science::Biological sciences
dc.titleN-to-C sequential ligation using peptidyl N,N-Bis(2-mercaptoethyl)amide building blocksen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.identifier.doihttp://dx.doi.org/10.1021/ol2031284


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