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Title: Metal-free pinnick-type oxidative amidation of aldehydes
Authors: Goh, Kien Soon
Tan, Choon-Hong
Issue Date: 2012
Source: Goh, K. S., & Tan, C.-H. (2012). Metal-free pinnick-type oxidative amidation of aldehydes. RSC Advances, 2(13), 5536-5538.
Series/Report no.: RSC advances
Abstract: A metal-free Pinnick-type oxidative amidation of aldehyde has been developed. Sodium chlorite was found to be a useful oxidant in coupling an aldehyde and amine to form an amide bond. A large variety of substrates are suitable and many functional groups are tolerated due to the mild nature of this amidation methodology. Optically active substrates were coupled smoothly with good yield and without racemization. As inexpensive reagents were used, it is cost effective even on a larger scale, indicating its potential for practical application.
ISSN: 2046-2069
DOI: 10.1039/c2ra20773g
Rights: © 2012 The Royal Society of Chemistry.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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