N-heterocyclic carbene catalyzed C-glycosylation : a concise approach from Stetter reaction
Tan, Shi Min
Teo, Hui Ping
Date of Issue2011
School of Physical and Mathematical Sciences
Described herein is the first example of an organocatalytic approach for acylanion addition to the anomeric carbon of 2-nitroglucal using an N-heterocyclic carbene catalyst. Control over the reaction conditions gives β-selective and nitro-eliminated C-glycosides, providing opportunities to produce new classes of C-glycoside.
© 2011 American Chemical Society.