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Title: Formal [4 + 1]- and [5 + 1]-annulation by an SN2–conjugate addition sequence : stereoselective synthesis of highly substituted carbocycles
Authors: Heng, Yi Li
Chiba, Shunsuke
Tong, Benny Meng Kiat
Chen, Hui
Chong, Sin Yee
Issue Date: 2012
Source: Tong, B. M. K., Chen, H., Chong, S. Y., Heng, Y. L., & Chiba, S. (2012). Formal [4 + 1]- and [5 + 1]-Annulation by an SN2–Conjugate Addition Sequence: Stereoselective Synthesis of Highly Substituted Carbocycles. Organic Letters, 14(11), 2826-2829.
Series/Report no.: Organic letters
Abstract: K2CO3-mediated reactions of 6-bromo-2-hexenoates and 7-bromo-2-heptenoate with active methylene compounds deliver highly substituted cyclopentane and cyclohexane derivatives, respectively via a sequence of SN2–conjugate addition reactions (formal [4 + 1]- and [5 + 1]-annulation) in a diastereoselective manner.
ISSN: 1523-7060
DOI: 10.1021/ol301044e
Rights: © 2012 American Chemical Society.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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